Stirring Unmagnetized Plasma

A new concept for spinning unmagnetized plasma is demonstrated experimentally. Plasma is confined by an axisymmetric multi-cusp magnetic field and biased cathodes are used to drive currents and impart a torque in the magnetized edge. Measurements show that flow viscously couples momentum from the magnetized edge (where the plasma viscosity is small) into the unmagnetized core (where the viscosity is large) and that the core rotates as a solid body. To be effective, collisional viscosity must overcome the ion-neutral drag due to charge exchange collisions

The Two-Fluid Dynamics and Energetics of the Asymmetric Magnetic Reconnection in Laboratory and Space Plasmas

Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative study of the dynamics and physical mechanisms governing the energy conversion in the laboratory and space plasma in the context of two-fluid physics, aided by numerical simulations. In strongly asymmetric reconnection layers with negligible guide field, the energy deposition to electrons is found to primarily occur in the electron diffusion region where electrons are demagnetized and diffuse. A large potential well is observed within the reconnection plane and ions are accelerated by the electric field toward the exhaust region. The present comparative study identifies the robust two-fluid mechanism operating in systems over six orders of magnitude in spatial scales and over a wide range of collisionality

Población y turismo rural en territorios de baja densidad demográfica en España

Se reflexiona en esta aportación sobre los espacios rurales en regresión poblacional y las posibilidades que ofrecen las actividades económicas vinculadas con el turismo rural y de interior para truncar o minimizar la crisis demográfica que sufren. Preferentemente se abordan su reciente evolución de la población y las causas y evolución del turismo rural. Pero de forma transversal se hacen también reflexiones sobre las políticas públicas de desarrollo local y los problemas de organización territorial de los ámbitos locales. El ámbito de estudio es genérico para España. El uso de una base de datos de escala municipal permite una buena radiografía del actual estado de la población y del poblamiento tanto para municipios rurales como urbanos. Para ello se han tomado datos del Instituto Nacional de Estadística y posteriormente se han georreferenciado con el apoyo de un SIG dando como resultado una ilustrativa cartografía que nos permite extraer algunas conclusiones

Perlecan Maintains microvessel integrity in vivo and modulates their formation in vitro

Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan. We found that perlecan was dispensable for blood vessel formation and maturation until embryonic day (E) 12.5. At later stages of development 40% of mutant embryos showed dilated microvessels in brain and skin, which ruptured and led to severe bleedings. Surprisingly, teratomas derived from perlecan-null ES cells showed efficient contribution of perlecan-deficient endothelial cells to an apparently normal tumor vasculature. However, in perlecan-deficient EBs the area occupied by an endothelial network and the number of vessel branches were significantly diminished. Addition of FGF-2 but not VEGF165 rescued the in vitro deficiency of the mutant ES cells. Furthermore, in the absence of perlecan in the EB matrix lower levels of FGFs are bound, stored and available for cell surface presentation. Altogether these findings suggest that perlecan supports the maintenance of brain and skin subendothelial BMs and promotes vasculo- and angiogenesis by modulating FGF-2 function

Energy transfer and electron energization in collisionless magnetic reconnection for different guide-field intensities

Electron dynamics and energization are one of the key components of magnetic field dissipation in collisionless reconnection. In 2D numerical simulations of magnetic reconnection, the main mechanism that limits the current density and provides an effective dissipation is most probably the electron pressure tensor term, that has been shown to break the frozen-in condition at the x-point. In addition, the electron-meandering-orbit scale controls the width of the electron dissipation region, where the electron temperature has been observed to increase both in recent Magnetospheric Multiple-Scale (MMS) observations as well as in laboratory experiments, such as the Magnetic Reconnection Experiment (MRX). By means of two-dimensional full-particle simulations in an open system, we investigate how the energy conversion and particle energization depend on the guide field intensity. We study the energy transfer from magnetic field to the plasma, ${\bf E}\cdot {\bf J}$ and the threshold guide field separating two regimes where either the parallel component, $E_{||}J_{||}$, or the perpendicular component, ${\bf E}_{\perp}\cdot {\bf J}_{\perp}$, dominate the energy transfer, confirming recent MRX results and also consistent with MMS observations. We calculate the energy partition between fields, kinetic, and thermal energy of different species, from electron to ion scales, showing there is no significant variation for different guide field configurations. Finally we study possible mechanisms for electron perpendicular heating by examining electron distribution functions and self-consistently evolved particle orbits in high guide field configurations

Optimal threshold for a positive hybrid capture 2 test for detection of human papillomavirus: data from the ARTISTIC trial

We present data on the use of the Hybrid Capture 2 (HC2) test for the detection of high-risk human papillomavirus (HR HPV) with different thresholds for positivity within a primary screening setting and as a method of triage for low-grade cytology. In the ARTISTIC population-based trial, 18,386 women were screened by cytology and for HPV. Cervical intraepithelial neoplasia lesions of grade two and higher (CIN2+ lesions) were identified for 453 women within 30 months of an abnormal baseline sample. When a relative light unit/cutoff (RLU/Co) ratio of > or = 1 was used as the threshold for considering an HC2 result positive, 15.6% of results were positive, and the proportion of CIN2+ lesions in this group was 14.7%. The relative sensitivity for CIN2+ lesion detection was 93.4%. When an RLU/Co ratio of > or = 2 was used as the threshold, there was a 2.5% reduction in positivity, with an increase in the proportion of CIN2+ lesions detected. The relative sensitivity decreased slightly, to 90.3%. Among women with low-grade cytology, HPV prevalences were 43.7% and 40.3% at RLU/Co ratios of > or = 1 and > or = 2, respectively. The proportions of CIN2+ lesions detected were 17.3% and 18.0%, with relative sensitivities of 87.7% at an RLU/Co ratio of > or = 1 and 84.2% at an RLU/Co ratio of > or = 2. At an RLU/Co ratio of > or = 1, 68.3% of HC2-positive results were confirmed by the Roche line blot assay, compared to 77.2% of those at an RLU/Co ratio of > or = 2. Fewer HC2-positive results were confirmed for 35- to 64-year-olds (50.3% at an RLU/Co ratio of > or = 1 and 63.2% at an RLU/Co ratio of > 2) than for 20- to 34-year-olds (78.7% at an RLU/Co ratio of > or = 1 and 83.7% at an RLU/Co ratio of > 2). If the HC2 test is used for routine screening as an initial test or as a method of triage for low-grade cytology, we would suggest increasing the threshold for positivity from the RLU/Co ratio of > or = 1, recommended by the manufacturer, to an RLU/Co ratio of > or = 2, since this study has shown that a beneficial balance between relative sensitivity and the proportion of CIN2+ lesions detected is achieved at this threshold