More about orbitally excited hadrons from lattice QCD

This is a second paper describing the calculation of spectroscopy for orbitally excited states from lattice simulations of Quantum Chromodynamics. New features include higher statistics for P-wave systems and first results for the spectroscopy of D-wave mesons and baryons, for relatively heavy quark masses. We parameterize the Coulomb gauge wave functions for P-wave and D-wave systems and compare them to those of their corresponding S-wave states.Comment: 21 pages plus 14 figs, 3 include

Predictors of Psychological Well-Being and Quality of Life in Patients with Hypertension: A Longitudinal Study.

Previous research has highlighted the positive impact of greater health-related quality of life (Hr-QoL) and subjective well-being (SWB) on chronic diseases’ severity and progression. There is a paucity of studies investigating the long-term trajectories of these variables among hypertensive patients. The present study aims to investigate the relationships between psychological variables (Type A and D personality, locus of control—LoC, self-esteem, and trait anxiety) with SWB and Hr-QoL in patients with hypertension and comorbid metabolic syndrome. A total of 185 volunteer patients (130 males, 70.3%; mean age 54 ± 10.93) were enrolled. Patients filled out measures of Hr-QoL and SWB, LoC, and self-esteem at three time points—Type A and D behaviors and anxiety measures only at baseline. Analyses were run through two-level hierarchical mixed models with repeated measures (Level 1) nested within participants (Level 2), controlling for sociodemographic and clinical confounders. Neither Hr-QoL nor SWB changed over time. Patients with greater self-esteem and internal LoC (and lower external LoC) increased their SWB and Hr-QoL up to 1-year follow-up. A greater Type A behavior and trait anxiety at baseline predicted a longitudinal increase in most of the dependent variables. Results suggest that it could be useful to tailor interventions targeting specific variables to increase Hr-QoL and SWB among hypertensive patients

Cognition-Enhancing Drugs: Can We Say No?

Normative analysis of cognition-enhancing drugs frequently weighs the liberty interests of drug users against egalitarian commitments to a level playing field. Yet those who would refuse to engage in neuroenhancement may well find their liberty to do so limited in a society where such drugs are widespread. To the extent that unvarnished emotional responses are world-disclosive, neurocosmetic practices also threaten to provide a form of faulty data to their users. This essay examines underappreciated liberty-based and epistemic rationales for regulating cognition-enhancing drugs

Italian versions of the rupture resolution rating system and the working alliance inventory observer short form: preliminary reliability and convergent validity

Objective: This study aimed to translate the Rupture Resolution Rating System (3RS) and the Working Alliance Inventory –Observer Short Form (WAI-O-S) into Italian. As a preliminary step toward validation, inter-rater reliability and convergent validity of the translated measures were also examined. // Method: First, forward–backward translation process was conducted to ensure conceptual and linguistic equivalence with the original English versions. Second, four trained raters independently applied the Italian versions of the 3RS and WAI-O-S to 47 psychotherapy sessions involving 20 different patients. Finally, inter-rater reliability (IRR) and convergent validity were analyzed. // Results: This study produced the first Italian versions of the 3RS and WAI-O-S, providing conceptually robust tools to assess therapeutic alliance and rupture–repair processes. Preliminary analyses showed acceptable inter-rater reliability for both measures, though some variability emerged in certain 3RS dimensions—particularly Therapist Withdrawal and Repair. Strong correlations between the 3RS Working Together score and the WAI-O-S total score offered preliminary evidence of convergent validity. // Conclusion: These preliminary findings provide initial support for the reliability and validity of the Italian 3RS and WAI-O-S. Further studies in larger and more diverse samples are necessary to examine their generalizability and clarify their applicability

Cross-national variations in reported discrimination among people treated for major depression worldwide : the ASPEN/INDIGO international study

No study has so far explored differences in discrimination reported by people with major depressive disorder (MDD) across countries and cultures. To (a) compare reported discrimination across different countries, and (b) explore the relative weight of individual and contextual factors in explaining levels of reported discrimination in people with MDD. Cross-sectional multisite international survey (34 countries worldwide) of 1082 people with MDD. Experienced and anticipated discrimination were assessed by the Discrimination and Stigma Scale (DISC). Countries were classified according to their rating on the Human Development Index (HDI). Multilevel negative binomial and Poisson models were used. People living in ‘very high HDI’ countries reported higher discrimination than those in ‘medium/low HDI’ countries. Variation in reported discrimination across countries was only partially explained by individual-level variables. The contribution of country-level variables was significant for anticipated discrimination only. Contextual factors play an important role in anticipated discrimination. Country-specific interventions should be implemented to prevent discrimination towards people with MDD

Carga asociada a la administración de rivastigmina transdérmica y a su presentación oral en cuidadores de pacientes con enfermedad de Alzheimer

Introducción: La enfermedad de Alzheimer (EA) es la demencia más común en la vejez, y conlleva un elevado estrés y una importante carga familiar. Objetivo: Evaluar las diferencias en satisfacción y carga asociada a la administración de rivastigmina por vía transdérmica y oral en cuidadores de pacientes con EA. Material y métodos: Estudio observacional, transversal y multicéntrico que incluyó a cuidadores de pacientes con EA de leve a moderadamente grave tratados con rivastigmina. Se evaluó la molestia asociada a la administración, la carga soportada y la satisfacción con el tratamiento. Resultados: Se incluyeron 497 cuidadores/grupo. La edad media de los cuidadores fue de 58,1 ± 14,2 años, y cerca del 75% eran mujeres. La mayoría de cuidadores eran parientes cercanos. La dificultad para tragar la medicación supuso molestias medias o elevadas al 38,2% de los cuidadores del grupo oral, mientras que la dificultad para colocar el parche lo fue para el 4,6%. El tratamiento transdérmico alcanza molestias medias de 6,7 puntos y el oral de 10,1 (p <0,0001); la sobrecarga no mostró diferencias significativas (21,4 ± 7,2 frente a 21,5 ± 6,9, respectivamente). Respecto a la facilidad de uso, el 88,3% consideró fácil o muy fácil el parche, y el 71,2% la cápsula. La afectación de la vida del cuidador fue nula o muy ocasional en el 66,4% con tratamiento transdérmico, frente al 51,1% con tratamiento oral. El 75,1% se mostraron satisfechos con el tratamiento transdérmico, frente al 55,9% con el oral (p <0,0001). Conclusiones: Los cuidadores de pacientes con EA mostraron una mayor satisfacción con el tratamiento de rivastigmina transdérmica y menores molestias asociadas

Carga asociada a la administración de rivastigmina transdérmica y a su presentación oral en cuidadores de pacientes con enfermedad de Alzheimer

Introducción: La enfermedad de Alzheimer (EA) es la demencia más común en la vejez, y conlleva un elevado estrés y una importante carga familiar. Objetivo: Evaluar las diferencias en satisfacción y carga asociada a la administración de rivastigmina por vía transdérmica y oral en cuidadores de pacientes con EA. Material y métodos: Estudio observacional, transversal y multicéntrico que incluyó a cuidadores de pacientes con EA de leve a moderadamente grave tratados con rivastigmina. Se evaluó la molestia asociada a la administración, la carga soportada y la satisfacción con el tratamiento. Resultados: Se incluyeron 497 cuidadores/grupo. La edad media de los cuidadores fue de 58,1 ± 14,2 años, y cerca del 75% eran mujeres. La mayoría de cuidadores eran parientes cercanos. La dificultad para tragar la medicación supuso molestias medias o elevadas al 38,2% de los cuidadores del grupo oral, mientras que la dificultad para colocar el parche lo fue para el 4,6%. El tratamiento transdérmico alcanza molestias medias de 6,7 puntos y el oral de 10,1 (p <0,0001); la sobrecarga no mostró diferencias significativas (21,4 ± 7,2 frente a 21,5 ± 6,9, respectivamente). Respecto a la facilidad de uso, el 88,3% consideró fácil o muy fácil el parche, y el 71,2% la cápsula. La afectación de la vida del cuidador fue nula o muy ocasional en el 66,4% con tratamiento transdérmico, frente al 51,1% con tratamiento oral. El 75,1% se mostraron satisfechos con el tratamiento transdérmico, frente al 55,9% con el oral (p <0,0001). Conclusiones: Los cuidadores de pacientes con EA mostraron una mayor satisfacción con el tratamiento de rivastigmina transdérmica y menores molestias asociadas

Online consultations in mental healthcare: Modelling determinants of use and experience based on an international survey study at the onset of the pandemic

Introduction: While online consultations have shown promise to be a means for the effective delivery of high -quality mental healthcare and the first implementations of these digital therapeutic contacts go back nearly two decades, uptake has remained limited over the years. The onset of the COVID-19 pandemic dramatically altered this relative standstill and created a unique turning point, with a massive amount of both professionals and clients having first hands-on experiences with technology in mental healthcare.Objective: The current study aimed to document the uptake of online consultations and explore if specific characteristics of mental health professionals across and beyond Europe could predict this.Methods: An international survey was designed to assess mental health professionals' (initial) experiences with online consultations at the onset of the pandemic: their willingness to make use of them and their prior and current experiences, alongside several personal characteristics. Logistic mixed-effects models were used to identify predictors of the use of online consultations, personal experience with this modality, and the sense of telepresence.Results: A total of 9115 healthcare professionals from 73 countries participated of which about two-thirds used online consultations during the initial COVID-19 outbreak. The current study identifies multiple determinants relating to the use and experience of online consultations, including the professionals' age, experience with the technology before the outbreak, the professional context, and training.Conclusions: Despite strong evidence supporting the relevance of training in digital mental health, this is clearly still lacking. Nevertheless, the COVID-19 pandemic presented a first, and potentially transformative, experience with online consultations for many healthcare professionals. The insights from this study can help supportprofessionals and, importantly, (mental) healthcare organisations to create optimal circumstances for selective and high-quality continued use of online consultations

Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing oxygen during preservation might improve post-transplant outcomes, particularly for kidneys subjected to greater degrees of preservation injury. This study aimed to investigate whether supplemental oxygen during hypothermic machine perfusion (HMP) could improve the outcome of kidneys donated after circulatory death. Methods This randomised, double-blind, paired, phase 3 trial was done in 19 European transplant centres. Kidney pairs from donors aged 50 years or older, donated after circulatory death, were eligible if both kidneys were transplanted into two different recipients. One kidney from each donor was randomly assigned using permuted blocks to oxygenated hypothermic machine perfusion (HMPO2), the other to HMP without oxygenation. Perfusion was maintained from organ retrieval to implantation. The primary outcome was 12-month estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation in pairs of donated kidneys in which both transplanted kidneys were functioning at the end of follow-up. Safety outcomes were reported for all transplanted kidneys. Intention-to-treat analyses were done. This trial is registered with the ISRCTN Registry, ISRCTN32967929, and is now closed. Findings Between March 15, 2015, and April 11, 2017, 197 kidney pairs were randomised with 106 pairs transplanted into eligible recipients. 23 kidney pairs were excluded from the primary analysis because of kidney failure or patient death. Mean eGFR at 12 months was 50·5 mL/min per 1·73 m2 (SD 19·3) in the HMPO2 group versus 46·7 mL/min per 1·73m2 (17·1) in HMP (mean difference 3·7 mL/min per 1·73m2, 95% CI −1·0 to 8·4; p=0·12). Fewer severe complications (Clavien-Dindo grade IIIb or more) were reported in the HMPO2 group (46 of 417, 11%, 95% CI 8% to 14%) than in the HMP group (76 of 474, 16%, 13% to 20%; p=0·032). Graft failure was lower with HMPO2 (three [3%] of 106) compared with HMP (11 [10%] of 106; hazard ratio 0·27, 95% CI 0·07 to 0·95; p=0·028). Interpretation HMPO2 of kidneys donated after circulatory death is safe and reduces post-transplant complications (grade IIIb or more). The 12-month difference in eGFR between the HMPO2 and HMP groups was not significant when both kidneys from the same donor were still functioning 1-year post-transplant, but potential beneficial effects of HMPO2 were suggested by analysis of secondary outcomes. Funding European Commission 7th Framework Programme