Safety & efficacy of lifileucel (LN-144) tumor infiltrating lymphocyte therapy in metastatic melanoma patients after progression on multiple therapies – independent review committee data update

Treatment options are limited for patients with advanced melanoma who have progressed on checkpoint inhibitors and targeted therapies such as BRAF/MEK inhibitors (if BRAF-V600E mutated). Adoptive cell therapy utilizing tumor-infiltrating lymphocytes (TIL) has shown antitumor efficacy with durable responses in heavily pretreated melanoma patients. Safety and efficacy of lifileucel, a centrally manufactured cryopreserved autologous TIL therapy assessed by both investigator and an independent review committee (IRC), are presented

Attempting to differentiate fast and slow intelligence: Using generalized item response trees to examine the role of speed on intelligence tests

© 2016 Elsevier Inc. Past research has indicated that a person's speed on cognitive tasks is correlated with his or her intelligence (Sheppard & Vernon, 2007). This has influenced the belief that faster respondents on intelligence tests may be more intelligent than those who are slower. Within this context, previous research has employed a one-parameter item response tree model to intelligence test data and concluded that there are two unique test-taking processes: one process for fast responses, and one for slow responses (Partchev & De Boeck, 2012). This study asks similar questions, but instead uses a two-parameter item response tree model. This model allows the researcher to calculate separate sets of item parameters for when an item is answered quickly versus when it is answered slowly. This item response tree model is fit to 503 respondents to a matrix intelligence test and 726 respondents to a verbal test. Results show that each item has separate parameters for fast and slow responses. Furthermore, for both matrix and verbal tests, the item discrimination parameters are consistently higher for fast responses, suggesting that fast responses to an item may contain more information about the ability of the respondent than slow responses.publisher: Elsevier articletitle: Attempting to differentiate fast and slow intelligence: Using generalized item response trees to examine the role of speed on intelligence tests journaltitle: Intelligence articlelink: http://dx.doi.org/10.1016/j.intell.2016.02.012 content_type: article copyright: © 2016 Elsevier Inc. All rights reserved.status: publishe

Exploring the spatio-temporal correlation of twin photons via frequency up-conversion

The entangled photon pairs (biphotons) produced from parametric down-conversion (PDC) in a (2) crystal are the key element for several quantum information and communication schemes. Recent theoretical investigations [1-2] have revealed the peculiar structure of the biphotonic correlation characterizing the entanglement of twin beams in the space-time domain. The biphotonic correlation in type I PDC is characterized in the near field by a X-shaped geometry, which turns out to be non-factorable in space and time, offering thus the relevant possibility of manipulating the temporal bandwidth of biphoton entanglement by acting on their spatial degrees of freedom. The name X-entanglement was coined to describe this geometry [1]. An other key feature which emerged is the extreme spatial and temporal localization of the biphotonic correlation, on the micrometer and femtosecond range, respectively. \ua9 2011 IEEE

Substituted dipyridophenazine complexes of Cr(III) : synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)

[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two

Controllable patterns of parametric solitons

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Controllable patterns of parametric solitons

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