Is it possible to establish reference values for ankle muscle isokinetic strength? A meta-analytical study

BACKGROUND: The importance of measuring ankle muscle strength (AMS) has been demonstrated in a variety of clinical areas. Much data has been accumulated using the Cybex Norm isokinetic dynamometer but a uniform framework does not exist. OBJECTIVE: To identify pertinent studies which have used the Cybex Norm to measure AMS in order to establish reference values. METHODS: A narrative review of the literature was used to identify papers that have used the Cybex Norm to measure isokinetic concentric and eccentric AMS. RESULTS: Fifty five research papers were identified but each study used a different isokinetic protocol. CONCLUSIONS: It is not possible to produce AMS reference values due to the wide variation in data collection methods. This is therefore an area of research that needs further exploration

Putting the ‘digital’ in Digital Intermediaries: the role of technical infrastructure in building business models

Digital Technology Innovation and Financial Business Practices The UK economy has a huge dependence on financial services, and this is increasingly based on digital platforms. Innovating new economic models around consumer financial services through the use of digital technologies is seen as increasingly important in developed economies. There are a number of drivers for this, ranging from national economic factors to the prosaic nature of enabling cheap, speedy and timely interactions for users. The potential for these new digital solutions is that they will allay an over-reliance on the traditional banking sector, which has proved itself to be unstable and risky, and we have seen a number of national policy moves to encourage growth in this sector. Partly as a result of the 2008 banking crisis, there has been an explosion in peer-to-peer financial services for non-professional consumers. These organisations act as intermediaries between users looking to trade goods or credit. However, building self-sustaining or profitable financial services within this novel space is itself fraught with commercial, regulatory, technical and social problems. This report addresses the mutual shaping of business models and innovations in digital technical infrastructure – both client-facing and administrative back-end – in two retail financial products currently in use in the United Kingdom: peer-to-peer consumer lending and a local digital/paper hybrid currency system. The two products and their issuing firms, Zopa Limited (Zopa) and The Bristol Pound Community Interest Company (the Bristol Pound), respectively, are established leaders in their respective product areas: Zopa was established in 2005 and the Bristol Pound in 2010. Each of these firms seeks to disrupt an established financial market through the application of digital technologies and processes: consumer lending for Zopa and retail payment for the Bristol Pound. Our research has involved teams from Lancaster University examining Zopa and Brunel University focusing on the Bristol Pound over approximately a one-year period from October 2013 to October 2014. Extensive interviews, document analysis, observation of user interactions, and other methods have been employed to develop the process analyses of the firms presented here. This report is comprised of three primary sections: descriptions of the business and technological processes of each of Zopa and the Bristol Pound, and a final analytical section drawing preliminary conclusions from the research presented.3DaRoC is funded by the UK’s Digital Economy ‘Research in the Wild’ initiative. It has a substantial research budget of over £320K, with £35K of additional industrial support

The isotropic-to-nematic transition in confined liquid crystals : an essentially non-universal phenomenon

Computer simulations are presented of the isotropic-to-nematic transition in a liquid crystal confined between two parallel plates a distance H apart. The plates are neutral and do not impose any anchoring on the particles. Depending on the shape of the pair potential acting between the particles, we find that the transition either changes from first-order to continuous at a critical film thickness H=Hx, or that the transition remains first-order irrespective of H. This demonstrates that the isotropic-to-nematic transition in confined geometry is not characterized by any universality class, but rather that its fate is determined by microscopic details. The resulting capillary phase diagrams can thus assume two topologies: one where the isotropic and nematic branches of the binodal meet at H=Hx, and one where they remain separated. For values of H where the transition is strongly first-order the shift DT of the transition temperature is in excellent agreement with the Kelvin equation. Not only is the relation DT~1/H recovered but also the prefactor of the shift is in quantitative agreement with the independently measured bulk latent heat and interfacial tension.Comment: To appear in Phys. Rev.

Implantable prosthetic pump boosts blood pressure: A concept

Prosthetic pump is proposed which can improve liver blood supply by boosting blood pressure locally to the organ. Device has potential use in treatment of cirrhosis of the liver

Fiber-modified polyurethane foam for ballistic protection

Closed-cell, semirigid, fiber-loaded, self-extinguishing polyurethane foam material fills voids around fuel cells in aircraft. Material prevents leakage of fuel and spreading of fire in case of ballistic incendiary impact. It also protects fuel cell in case of exterior fire

Andersen-Tawil Syndrome

Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients with ATS. To date, KCNJ2 is the only gene implicated in ATS, accounting for approximately 60% of cases. ATS is a unique channelopathy, and represents the first link between cardiac and skeletal muscle excitability. The arrhythmias observed in ATS are distinctive; patients may be asymptomatic, or minimally symptomatic despite a high arrhythmia burden with frequent ventricular ectopy and bidirectional ventricular tachycardia. However, patients remain at risk for life-threatening arrhythmias, including torsades de pointes and ventricular fibrillation, albeit less commonly than observed in other genetic arrhythmia syndromes. The characteristic heterogeneity at both the genotypic and phenotypic levels contribute to the continued difficulties with appropriate diagnosis, risk stratification, and effective therapy. The initial recognition of a syndromic association of clinically diverse symptoms, and the subsequent identification of the underlying molecular genetic basis of ATS has enhanced both clinical care, and our understanding of the critical function of Kir2.1 on skeletal muscle excitability and cardiac action potentia

Interpreting infrastructure: Defining user value for digital financial intermediaries.

The 3DaRoC project is exploring digital connectivity and peer-to-peer relationships in financial services. In the light of the near collapse of the UK and world financial sector, understanding and innovating new and more sustainable approaches to financial services is now a critical topic. At the same time, the increasing penetration and take-up of robust high-speed networks, dependable peerto- peer architectures and mobile multimedia technologies offer novel platforms for offering financial services over the Internet. These new forms of digital connectivity give rise to opportunities in doing financial transactions in different ways and with radically different business models that offer the possibility of transforming the marketplace. One area in the digital economy that has had such an effect is in the ways that users access and use digital banking and payment services. The impact of the new economic models presented by these digital financial services is yet to be fully determined, but they have huge potential as disruptive innovations, with a potentially transformative effect on the way that services are offered to users. Little is understood about how technical infrastructures impact on the ways that people make sense of the financial services that they use, or on how these might be designed more effectively. 3DaRoC is exploring this space working with our partners and end users to prototype and evaluate new online, mobile, ubiquitous and tangible technologies, exploring how these services might be extended.Executive Summary: Drawing from Studies of Use - the value, use and interpretation of infrastructure in digital intermediaries to their users. The UK economy has a huge dependence on financial services, and this is increasingly based on digital platforms. Innovating new economic models around consumer financial services through the use of digital technologies is seen as increasingly important in developed economies. There are a number of drivers for this, ranging from national economic factors to the prosaic nature of enabling cheap, speedy and timely interactions for users. The potential for these new digital solutions is that they will allay an over-reliance on the traditional banking sector, which has proved itself to be unstable and risky, and we have seen a number of national policy moves to encourage growth in this sector. Partly as a result of the 2008 banking crisis, there has been an explosion in peer-to-peer financial services for non-professional consumers. These organisations act as intermediaries between users looking to trade goods or credit. However, building self-sustaining or profitable financial services within this novel space is itself fraught with commercial, regulatory, technical and social problems. This document reports on the value, use and interpretation of infrastructure in digital intermediaries to their users, describing analysis of contextual field studies carried out in two retail digital financial intermediary organisations: Zopa Limited and the Bristol Pound. It forms the second milestone document in the 3DaRoC project, developing patterns of use that have arisen on the back of the technical infrastructures in the two organisations that form cases for examination. Its purpose is to examine how the two different technical infrastructures that underpin the transactions that they support–composed of the back-office hardware and software, data structures, the networking and communications technologies used, supported consumer devices, and the user interfaces and interaction design–have provided opportunities for users to realise their financial and other needs. While we orient towards the issues of service use (and its problems), we also examine the activities and expectations of their various users. Our research has involved teams from Lancaster University examining Zopa and Brunel University focusing on the Bristol Pound over approximately a one-year period from October 2013 to October 2014. Extensive interviews, document analysis, observation of user interactions, and other methods have been employed to develop the process analyses of the firms presented here. This report comprises of three key sections: descriptions of the user demographics for Zopa and the Bristol Pound, a discussion about the user experience and its role in community, and an examination of the role of usage data in the development of these a products. We conclude with final analytical section drawing preliminary conclusions from the research presented.The 3DaRoC project is funded by the RCUK Digital Economy ‘Research in the Wild’ theme (grant no. EP/K012304/1)

A small-scale test for fiber release from carbon composites

A test method was developed to determine relative fiber loss from pyrolyzed composites with different resins and fiber construction. Eleven composites consisting of woven and unwoven carbon fiber reinforcement and different resins were subjected to the burn and impact test device. The composites made with undirectional tape had higher fiber loss than those with woven fabric. Also, the fiber loss was inversely proportional to the char yield of the resin

Lithium abundances in nearby FGK dwarf and subgiant stars: internal destruction, Galactic chemical evolution, and exoplanets

We derive atmospheric parameters and lithium abundances for 671 stars and include our measurements in a literature compilation of 1381 dwarf and subgiant stars. First, a "lithium desert" in the effective temperature (Teff) versus lithium abundance (A_Li) plane is observed such that no stars with Teff~6075 K and A_Li~1.8 are found. We speculate that most of the stars on the low A_Li side of the desert have experienced a short-lived period of severe surface lithium destruction as main-sequence or subgiant stars. Next, we search for differences in the lithium content of thin-disk and thick-disk stars, but we find that internal processes have erased from the stellar photospheres their possibly different histories of lithium enrichment. Nevertheless, we note that the maximum lithium abundance of thick-disk stars is nearly constant from [Fe/H]=-1.0 to -0.1, at a value that is similar to that measured in very metal-poor halo stars (A_Li~2.2). Finally, differences in the lithium abundance distribution of known planet-host stars relative to otherwise ordinary stars appear when restricting the samples to narrow ranges of Teff or mass, but they are fully explained by age and metallicity biases. We confirm the lack of a connection between low lithium abundance and planets. However, we find that no low A_Li planet-hosts are found in the desert Teff window. Provided that subtle sample biases are not responsible for this observation, this suggests that the presence of gas giant planets inhibit the mechanism responsible for the lithium desert.Comment: ApJ, in press. Complete Tables 1 and 3 are available upon reques

Finite-size effects at first-order isotropic-to-nematic transitions

We present simulation data of first-order isotropic-to-nematic transitions in lattice models of liquid crystals and locate the thermodynamic limit inverse transition temperature $\epsilon_\infty$ via finite-size scaling. We observe that the inverse temperature of the specific heat maximum can be consistently extrapolated to $\epsilon_\infty$ assuming the usual $\alpha / L^d$ dependence, with $L$ the system size, $d$ the lattice dimension and proportionality constant $\alpha$. We also investigate the quantity $\epsilon_{L,k}$, the finite-size inverse temperature where $k$ is the ratio of weights of the isotropic to nematic phase. For an optimal value $k = k_{\rm opt}$, $\epsilon_{L,k}$ versus $L$ converges to $\epsilon_\infty$ much faster than $\alpha/L^d$, providing an economic alternative to locate the transition. Moreover, we find that $\alpha \sim \ln k_{\rm opt} / {\cal L}_\infty$, with ${\cal L}_\infty$ the latent heat density. This suggests that liquid crystals at first-order IN transitions scale approximately as $q$-state Potts models with $q \sim k_{\rm opt}$.Comment: To appear in Physical Review