Thermal analysis of a commercial plate fin heat exchanger with non-uniform inlet flow conditions

In studies using computational fluid dynamics software, very often a uniform air stream is applied as inlet boundary condition of a heat exchanger. In actual applications, however, the inlet flow conditions are not uniform. Therefore, the effect of non-uniformities on the thermal performance is characterized in a wind tunnel for a commercially available plate water/air heat exchanger. Three non-uniform flow conditions are investigated. The heat exchanger is 275 mm wide and 295 mm high. Three non-uniformities are created by placing a plate 10 cm upstream of the heat exchanger: the first one covers the right-hand side of the heat exchanger, the second one covers the top half of the heat exchanger and the last obstruction consists of a circular hole of 150 mm diameter in the middle of a plate. Only the circular obstruction has a significant influence on the heat transfer rate: the external convective resistance is up to 25% higher compared to the uniform case. The measurement results presented in this study can be used by other researchers to validate numerical simulations with non-uniform inlet conditions

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells

Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression. Therefore, understanding what activates ERα is critical for cancer treatment in particular and cell biology in general. Using biochemical approaches and superresolution microscopy, we show that estrogen drives membrane ERα into endosomes in breast cancer cells and that its fate is determined by the presence of fibronectin (FN) in the extracellular matrix; it is trafficked to lysosomes in the absence of FN and avoids the lysosomal compartment in its presence. In this context, FN prolongs ERα half-life and strengthens its transcriptional activity. We show that ERα is associated with β1-integrin at the membrane, and this integrin follows the same endocytosis and subcellular trafficking pathway triggered by estrogen. Moreover, ERα+ vesicles are present within human breast tissues, and colocalization with β1-integrin is detected primarily in tumors. Our work unravels a key, clinically relevant mechanism of microenvironmental regulation of ERα signaling.Fil: Sampayo, Rocío Guadalupe. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Toscani, Andrés Martin. Universidad Nacional de Luján; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Rubashkin, Matthew G.. University of California; Estados UnidosFil: Thi, Kate. Lawrence Berkeley National Laboratory; Estados UnidosFil: Masullo, Luciano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Violi, Ianina Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Lakins, Jonathon N.. University of California; Estados UnidosFil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Hines, William C.. Lawrence Berkeley National Laboratory; Estados UnidosFil: Coluccio Leskow, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Nacional de Luján; ArgentinaFil: Stefani, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Chialvo, Dante Renato. Universidad de Buenos Aires; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología. Centro Internacional de Estudios Avanzados; ArgentinaFil: Bissell, Mina J.. Lawrence Berkeley National Laboratory; Estados UnidosFil: Weaver, Valerie M.. University of California; Estados UnidosFil: Simian, Marina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentin

Moisture Accumulation and Its Impact on the Thermal Performance of Pipe Insulation for Chilled Water Pipes in High Performance Buildings

Mechanical pipe insulation systems are commonly applied to cold piping surfaces in most industrial and commercial buildings in order to limit the heat losses and prevent water vapor condensation on the pipe exterior surfaces. Due to the fact that the surface temperature of these pipelines is normally below the ambient dew point temperature, water vapor diffuses inside the pipe insulation systems and often condenses when it reaches the pipe exterior surfaces. The water droplets accumulated in the pipe insulation system increase its overall thermal conductivity by thermal bridging the cells or the fibers of the insulation material. The moisture ingress into pipe insulation threatens the thermal performance and the overall efficiency of the building mechanical system. This phenomenon is also responsible for the mold growth inside occupied spaces and causes the pipelines to be more vulnerable to corrosion. Although a wide range of vapor barriers are used for preventing water vapor penetration into pipe insulation, common experience in the field shows that water vapor will inevitably ingress into the insulation materials from the end joints or from the cracks created during insulation installation. How to account for the moisture ingress on pipe insulation service life and thermal performance is still an open question. Thermal conductivity is one of the most important properties for evaluating the thermal performance of the pipe insulation systems. Using a new test apparatus, the thermal conductivity of pipe insulation systems below ambient temperature and in wet conditions with moisture ingress was measured. Fiberglass and phenolic pipe insulation were tested to investigate the moisture effects on the material thermal conductivity. The data showed that these two types of pipe insulation systems had quite different water absorption rates due to different characteristics of the material and its structure. A serious degradation of fiberglass pipe insulation thermal performance was observed and the thermal conductivity increased by as much as 3 times when the moisture content was about 12 percent in volume. Tested at a different condition, the thermal conductivity of phenolic pipe insulation increased to 1.6 times of the original value and the moisture content was 5% in volume. Considering the gravity effect, the moisture content on the top and bottom C-shells were separately measured and discussed in this paper

Regional pressure and temperature differences across the injured human brain : comparisons between intraparenchymal and ventricular measurements

Introduction: Intraparenchymal, multimodality sensors are commonly used in the management of patients with severe traumatic brain injury (TBI). The ‘gold standard’, based on accuracy, reliability and cost for intracranial pressure (ICP) monitoring is within the cerebral ventricle (external strain gauge). There are no standards yet for intracerebral temperature monitoring and little is known of temperature differences between brain tissue and ventricle. The aim of the study therefore was to determine pressure and temperature differences at intraparenchymal and ventricular sites during five days of continuous neurominitoring. Methods: Patients with severe TBI requiring emergency surgery. Inclusion criteria: patients who required ICP monitoring were eligible for recruitment. Two intracerebral probe types were used: a) intraventricular, dual parameter sensor (measuring pressure, temperature) with inbuilt catheter for CSF drainage: b) multiparameter intraparenchymal sensor measuring pressure, temperature and oxygen partial pressure. All sensors were inserted during surgery and under aseptic conditions. Results: Seventeen patients, 12 undergoing neurosurgery (decompressive craniectomy n=8, craniotomy n=4) aged 21–78 years were studied. Agreement of measures for 9540 brain tissue-ventricular temperature ‘pairs’ and 10,291 brain tissue-ventricular pressure ‘pairs’ were determined using mixed model to compare mean temperature and pressure for longitudinal data. There was no significant overall difference for mean temperature (p=0.92) or mean pressure readings (p=0.379) between tissue and ventricular sites. With 95.8% of paired temperature readings within 2SD (−0.4 to 0.4°C) differences in temperature between brain tissue and ventricle were clinically insignificant. For pressure, 93.5% of readings pairs fell within the 2SD range (−9.4756 to 7.8112 mmHg) (Fig. 2). However, for individual patients, agreement for mean tissue-ventricular pressure differences was poor on occasions. Conclusions: There is good overall agreement between paired temperature measurements obtained from deep white matter and brain ventricle in patients with and without early neurosurgery. For paired ICP measurements, 93.5% of readings were within 2SD of mean difference. Whilst the majority of paired readings were comparable (within 10mmHg) clinically relevant tissue-ventricular dissociations were noted. Further work is required to unravel the events responsible for short intervals of pressure dissociation before tissue pressure readings can be definitively accepted as a reliable surrogate for ventricular pressure.</p

Bee-Friendly Beef: Developing Biodiverse Pastures to Increase Ecosystem Services

The capacity of grasslands to provide ecosystem services, such as pollinator resources, is often limited by lack of plant biodiversity. This is true of grasslands in the eastern US that are dominated by tall fescue (Festuca arundinacea) a non-native, cool-season grass that is typically toxic to cattle. This paper summarizes a research project in Virginia, USA exploring the idea that ecosystem services provided by tall fescue-dominated grasslands can be improved by increasing the plant biodiversity available to beef cattle and bees. Within three 6.5 ha tall fescue grasslands, we established 0.8 ha plots with a 17 species mix of native warm-season grasses (NWSGs) and wildflowers. Beginning in 2018, we measured grass and wildflower establishment, attractiveness of wildflowers to bees, abundance and diversity of bee communities in biodiverse pastures and adjacent tall fescue pastures. Many of the 18 species sown established well expect for NWSGs. Competition from wildflowers likely suppressed native grasses and limited forage availability for beef cattle. Cattle largely ignored the wildflowers. This finding suggests that cattle and pollinators can share this biodiverse grassland as their primary foods are mutually exclusive. The total number of bees was almost double in wildflower-enhanced grasslands compared with more typical tall fescue grasslands. We observed most bee landings on purple coneflower (Echinacea purpurea) and anise hyssop (Agastache foeniculum). Several weedy species such as milkweed (Asclepias syriaca) and musk thistle (Carduus nutans) were also attractive to bees. Preliminary analyses identified at least 28 bee morphospecies and a distinct bee community present in wildflower pastures. While these results were promising, more research is needed on ways to establish biodiverse grasslands so that a more optimal balance of grasses and wildflowers can be sustained to benefit both cattle production and pollinators

Feasibility of the implementation of solar heat sources for bridge deck applications

Deicing salts have caused damage and early failure of the concrete cover and corrosion of reinforcing steel of concrete bridge decks. The use of wax to internally seal Portlant Cement concrete bridge decks and the use of monomers to polymerize concrete have been researched as methods to repair deteriorated decks and to prevent the penetration of salt into the conrete. Both methods require heating the concrete to a depth of two inches to temperatures of 160 to 190 degrees F. Eelctrical and propane heating systems are expensive to buy and operate. Solar equipment may be more simple and uses a source of energy that is both free and non-polluting. the installation of two cathodic protection systems as part of the Federal Highway Administration's Demonstration Project No. 34, "Cathodic Protection for Reinforced Concrete Bridge Decks". Two different types of cathodic protection systems were installed under this contract. The first system known as a "slotted" or non-overlay system consists of anodes which are installed in slots that have been sawed in the bridge deck. The second system is an overlay system in which the anodes are installed on top of the deck and then a 2 inch high density concrete overlay is piaced. Both systems were of the impressed current type using the local utility company for power. This is the second year evaluation of the project.N

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI

Assessing the Permeability of Engineered Capillary Networks in a 3D Culture

Many pathologies are characterized by poor blood vessel growth and reduced nutrient delivery to the surrounding tissue, introducing a need for tissue engineered blood vessels. Our lab has developed a 3D co-culture method to grow interconnected networks of pericyte-invested capillaries, which can anastamose with host vasculature following implantation to restore blood flow to ischemic tissues. However, if the engineered vessels contain endothelial cells (ECs) that are misaligned or contain wide junctional gaps, they may function improperly and behave more like the pathologic vessels that nourish tumors. The purpose of this study was to test the resistance to permeability of these networks in vitro, grown with different stromal cell types, as a metric of vessel functionality. A fluorescent dextran tracer was used to visualize transport across the endothelium and the pixel intensity was quantified using a customized MATLAB algorithm. In fibroblast-EC co-cultures, the dextran tracer easily penetrated through the vessel wall and permeability was high through the first 5 days of culture, indicative of vessel immaturity. Beyond day 5, dextran accumulated at the periphery of the vessel, with very little transported across the endothelium. Quantitatively, permeability dropped from initial levels of 61% to 39% after 7 days, and to 7% after 2 weeks. When ECs were co-cultured with bone marrow-derived mesenchymal stem cells (MSCs) or adipose-derived stem cells (AdSCs), much tighter control of permeability was achieved. Relative to the EC-fibroblast co-cultures, permeabilities were reduced 41% for the EC-MSC co-cultures and 50% for the EC-AdSC co-cultures after 3 days of culture. By day 14, these permeabilities decreased by 68% and 77% over the EC-fibroblast cultures. Co-cultures containing stem cells exhibit elevated VE-cadherin levels and more prominent EC-EC junctional complexes when compared to cultures containing fibroblasts. These data suggest the stromal cell identity influences the functionality and physiologic relevance of engineered capillary networks

Demographic and state-level trends in mortality due to ischemic heart disease in the United States frmo 1999-2019

Although there have been advances in ischemic heart disease (IHD) care, variation in IHD-related mortality trends across the United States has not been well described. We used the CDC-WONDER database to evaluate variation in IHD-related mortality for demographic groups in the U.S. between 1999 and 2019. Age-adjusted mortality rates (AAMR) were stratified by sex, race, Hispanic ethnicity, and U.S. state. Crude mortality rates were evaluated using 10-year age groups. IHD-related AAMR decreased from 195 to 88 per 100,000 nationally, with slower decline from 2010-2019 (average annual percent change [AAPC] -2.6% [95% CI -2.9% to -2.2%) compared to 2002-2010 (AAPC -5.3% [95% CI -5.6% to -4.9%]). All groups had decreases in AAMR, though black populations persistently had the highest AAMR, and women had greater relative decreases than men. AAPC was -3.7% for white men; -4.7% for white women; -3.9% for black men; -4.9% for black women; -4.1% for Hispanic men, and -5.1% for Hispanic women. Populations ≥65 years old had greater relative mortality declines compared to populations <65 years. The median AAMR (2019) and AAPC (1999-2019) across states was 86.3 (range 58 – 134) and -3.8% (range -1.7% to -4.8%), respectively. In conclusion, mortality declines due to IHD have slowed in the U.S., with significant geographic variation. Black populations persistently had the highest AAMR, and declines were relatively greater for women and populations ≥65 years. The impact of demographics and geography on IHD should be further explored and addressed as part of public health measures