A consensus research agenda for optimising nasal drug delivery

Nasal drug delivery has specific challenges which are distinct from oral inhalation, alongside which it is often considered. The next generation of nasal products will be required to deliver new classes of molecule, e.g. vaccines, biologics and drugs with action in the brain or sinuses, to local and systemic therapeutic targets. Innovations and new tools/knowledge are required to design products to deliver these therapeutic agents to the right target at the right time in the right patients. We report the outcomes of an expert meeting convened to consider gaps in knowledge and unmet research needs in terms of (i) formulation and devices, (ii) meaningful product characterization and modeling, (iii) opportunities to modify absorption and clearance. Important research questions were identified in the areas of device and formulation innovation, critical quality attributes for different nasal products, development of nasal casts for drug deposition studies, improved experimental models, the use of simulations and nasal delivery in special populations. We offer these questions as a stimulus to research and suggest that they might be addressed most effectively by collaborative research endeavors

Investigation of the parameters used in fused deposition modeling of poly(lactic acid) to optimize 3D printing sessions

peer reviewe

Proton-dependent oligopeptide transporter (POT)-mediated uptake in the novel blood-brain barrier cell line, hCMEC/D3

info:eu-repo/semantics/nonPublishe

Intracellular localization of human peptide/histidine transporter 1 (hPHT1) in the human gastrointestinal adenocarcinoma cell line HT-29

info:eu-repo/semantics/nonPublishe

Establishment of a hPepT1-stably transfected human cell line: characterization of transporter expression and function

info:eu-repo/semantics/nonPublishe