Integrated Stellar Populations: Confronting Photometry with Spectroscopy

We investigate the ability of spectroscopic techniques to yield realistic star formation histories (SFHs) for the bulges of spiral galaxies based on a comparison with their observed broadband colors. Full spectrum fitting to optical spectra indicates that recent (within ~1 Gyr) star formation activity can contribute significantly to the V-band flux, whilst accounting for only a minor fraction of the stellar mass budget which is made up primarily of old stars. Furthermore, recent implementations of stellar population (SP) models reveal that the inclusion of a more complete treatment of the thermally pulsating asymptotic giant branch (TP-AGB) phase to SP models greatly increases the NIR flux for SPs of ages 0.2-2 Gyr. Comparing the optical--NIR colors predicted from population synthesis fitting, using models which do not include all stages of the TP-AGB phase, to the observed colors reveals that observed optical--NIR colors are too red compared to the model predictions. However, when a 1 Gyr SP from models including a full treatment the TP-AGB phase is used, the observed and predicted colors are in good agreement. This has strong implications for the interpretation of stellar populations, dust content, and SFHs derived from colors alone.Comment: 6 pages, 6 figures, accepted for publication in the Astrophysical Journa

Entropy, Ergodicity and Stem Cell Multipotency

Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluctuations of the stem cell surface marker Sca1 in mouse hematopoietic progenitor cells using a simple stochastic model and find that the observed dynamics naturally lie close to a critical state, thereby producing a diverse population that is able to respond rapidly to environmental changes. We propose an information-theoretic interpretation of these results that views cellular multipotency as an instance of maximum entropy statistical inference.Comment: 6 pages, 3 figure

Mixed methods evaluation of an educational intervention to change mental health nurses' attitudes to people diagnosed with borderline personality disorder

Aims and objectives: To evaluate and explore mental health nurses’ responses to and experience of an educational intervention to improve attitudes towards people with a diagnosis of Borderline Personality Disorder. Report findings are concordant with relevant EQUATOR guidelines (STROBE and COREQ).Background: Attitudes towards people with a diagnosis of Borderline Personality Disorder are poorer than for people with other diagnoses. There is limited evidence about what might improve this situation. One intervention with reportedly good effect uses an underlying biosocial model of borderline personality disorder. No previous intervention has been co-produced with an expert-by-experience. We developed and delivered a 1-day intervention comprising these elements.Design: A mixed-methods design was used comprising prospective uncontrolled cohort intervention and qualitative elements. Participants were mental health nursing staff working in inpatient and community settings in one NHS Board in Scotland, UK.Methods: Measurement of cognitive and emotional attitudes to people with a borderline personality diagnosis at pre- and post- intervention (N =28) and at 4-month follow-up. Focus groups were used to explore participants’ experiences of the intervention (N =11).Results: Quantitative evaluation revealed some sustained changes consistent with expected attitudinal gains in relation to the perceived treatment characteristics of this group, the perception of their suicidal tendencies, and negative attitudes in general. Qualitative findings revealed some hostility towards the underpinning biosocial model and positive appreciation for the involvement of an expert-by-experience. Conclusions: Sustained benefits of an educational intervention for people working with people diagnosed with BPD in some but not all areas. Participants provided contrasting messages about what they think will be useful.Relevance to clinical practice: The study provides further evidence for incorporation of a biosocial model into staff training as well as the benefits of expert-by-experience co-production. Mental health nurses, however, believe that more well-resourced services are the key to improving care. <br/

Knots, Braids and Hedgehogs from the Eikonal Equation

The complex eikonal equation in the three space dimensions is considered. We show that apart from the recently found torus knots this equation can also generate other topological configurations with a non-trivial value of the $\pi_2(S^2)$ index: braided open strings as well as hedgehogs. In particular, cylindric strings i.e. string solutions located on a cylinder with a constant radius are found. Moreover, solutions describing strings lying on an arbitrary surface topologically equivalent to cylinder are presented. We discus them in the context of the eikonal knots. The physical importance of the results originates in the fact that the eikonal knots have been recently used to approximate the Faddeev-Niemi hopfions.Comment: 15 pages, 5 figure

Star Clusters in M31. V. Evidence for Self-Enrichment in Old M31 Clusters from Integrated Spectroscopy

In the past decade, the notion that globular clusters (GCs) are composed of coeval stars with homogeneous initial chemical compositions has been challenged by growing evidence that they host an intricate stellar population mix, likely indicative of a complex history of star formation and chemical enrichment. Several models have been proposed to explain the existence of multiple stellar populations in GCs, but no single model provides a fully satisfactory match to existing data. Correlations between chemistry and global parameters such as cluster mass or luminosity are fundamental clues to the physics of GC formation. In this Letter, we present an analysis of the mean abundances of Fe, Mg, C, N, and Ca for 72 old GCs from the Andromeda galaxy. We show for the first time that there is a correlation between the masses of GCs and the mean stellar abundances of nitrogen, spanning almost two decades in mass. This result sheds new light on the formation of GCs, providing important constraints on their internal chemical evolution and mass loss history.Comment: To appear in the Astrophysical Journal Letter

Sample size calculations for cluster randomised controlled trials with a fixed number of clusters

Background\ud Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design effect or inflation factor. However, where the number of clusters are fixed in advance, but where it is possible to increase the number of individuals within each cluster, as is frequently the case in health service evaluation, sample size formulae have been less well studied. \ud \ud Methods\ud We systematically outline sample size formulae (including required number of randomisation units, detectable difference and power) for CRCTs with a fixed number of clusters, to provide a concise summary for both binary and continuous outcomes. Extensions to the case of unequal cluster sizes are provided. \ud \ud Results\ud For trials with a fixed number of equal sized clusters (k), the trial will be feasible provided the number of clusters is greater than the product of the number of individuals required under individual randomisation ($n_i$) and the estimated intra-cluster correlation ($\rho$). So, a simple rule is that the number of clusters ($\kappa$) will be sufficient provided: \ud \ud $\kappa$ > $n_i$ x $\rho$\ud \ud Where this is not the case, investigators can determine the maximum available power to detect the pre-specified difference, or the minimum detectable difference under the pre-specified value for power. \ud \ud Conclusions\ud Designing a CRCT with a fixed number of clusters might mean that the study will not be feasible, leading to the notion of a minimum detectable difference (or a maximum achievable power), irrespective of how many individuals are included within each cluster. \ud \u

Experimental test of higher-order Laguerre–Gauss modes in the 10 m Glasgow prototype interferometer

Brownian noise of dielectric mirror coatings is expected to be one of the limiting noise sources, at the peak sensitivity, of next generation ground based interferometric gravitational wave (GW) detectors. The use of higher-order Laguerre–Gauss (LG) beams has been suggested to reduce the effect of coating thermal noise in future generations of gravitational wave detectors. In this paper we describe the first test of interferometry with higher-order LG beams in an environment similar to a full-scale gravitational wave detector. We compare the interferometric performance of higher-order LG modes and the fundamental mode beams, injected into a 10 m long suspended cavity that features a finesse of 612, a value chosen to be typical of future gravitational wave detectors. We found that the expected mode degeneracy of the injected LG3, 3 beam was resolved into a multiple peak structure, and that the cavity length control signal featured several nearby zero crossings. The break up of the mode degeneracy is due to an astigmatism (defined as |Rcy − Rcx|) of 5.25 ± 0.5 cm on one of our cavity mirrors with a radius of curvature (Rc) of 15 m. This observation agrees well with numerical simulations developed with the FINESSE software. We also report on how these higher-order mode beams respond to the misalignment and mode mismatch present in our 10 m cavity. In general we found the LG3, 3 beam to be considerably more susceptible to astigmatism and mode mismatch than a conventional fundamental mode beam. Therefore the potential application of higher-order Laguerre–Gauss beams in future gravitational wave detectors will impose much more stringent requirements on both mode matching and mirror astigmatism

Faecal incontinence persisting after childbirth : a 12 year longitudinal study

© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.Peer reviewedPostprin

Density and abundance of badger social groups in England and Wales in 2011-2013

This is the final version of the article. Available from Nature Publishing Group via the DOI in this record.In the United Kingdom, European badgers Meles meles are a protected species and an important wildlife reservoir of bovine tuberculosis. We conducted a survey of badger dens (main setts) in 1614 1 km squares across England and Wales, between November 2011 and March 2013. Using main setts as a proxy for badger social groups, the estimated mean density of badger social groups in England and Wales was 0.485 km(-2) (95% confidence interval 0.449-0.521) and the estimated abundance of social groups was 71,600 (66,400-76,900). In the 25 years since the first survey in 1985-88, the annual rate of increase in the estimated number of badger social groups was 2.6% (2.2-2.9%), equating to an 88% (70-105%) increase across England and Wales. In England, we estimate there has been an increase of 103% (83-123%) in badger social groups, while in Wales there has been little change (-25 to +49%).We are grateful to the thousands of landowners for their kind co-operation in granting access to their land. This study was funded by the Department for Environment, Food and Rural Affairs, as part of England and Wales national research activities. Fieldwork was conducted by staff of the National Wildlife Management Centre. Access to data from the 1985–88 survey was licensed by the Joint Nature Conservation Committee, to whom the rights of the Nature Conservancy Council had passed