Many-body Effects in Angle-resolved Photoemission: Quasiparticle Energy and Lifetime of a Mo(110) Surface State

In a high-resolution photoemission study of a Mo(110) surface state various contributions to the measured width and energy of the quasiparticle peak are investigated. Electron-phonon coupling, electron-electron interactions and scattering from defects are all identified mechanisms responsible for the finite lifetime of a valence photo-hole. The electron-phonon induced mass enhancement and rapid change of the photo-hole lifetime near the Fermi level are observed for the first time.Comment: RevTEX, 4 pages, 4 figures, to be published in PR

Absence Seizures as a Feature of Juvenile Myoclonic Epilepsy in Rhodesian Ridgeback Dogs

Myoclonic epilepsy in Rhodesian Ridgeback (RR) dogs is characterized by myoclonic seizures occurring mainly during relaxation periods, a juvenile age of onset and generalized tonic-clonic seizures in one-third of patients. An 8-month-old female intact RR was presented for myoclonic seizures and staring episodes that both started at 10 weeks of age. Testing for the DIRAS1 variant indicated a homozygous mutant genotype. Unsedated wireless video-electroencephalography (EEG) identified frequent, bilaterally synchronous, generalized 4 Hz spike-and-wave complexes (SWC) during the staring episodes in addition to the characteristic myoclonic seizures with generalized 4-5 Hz SWC or 4-5 Hz slowing. Photic stimulation did not evoke a photoparoxysmal response. Repeat video-EEG 2 months after initiation of levetiracetam treatment disclosed a >95% decrease in frequency of myoclonic seizures, and absence seizures were no longer evident. Absence seizures represent another seizure type in juvenile myoclonic epilepsy (JME) in RR dogs, which reinforces its parallels to JME in humans.Peer reviewe

Charge-imbalance effects in intrinsic Josephson systems

We report on two types of experiments with intrinsic Josephson systems made from layered superconductors which show clear evidence of nonequilibrium effects: 1. In 2-point measurements of IV-curves in the presence of high- frequency radiation a shift of the voltage of Shapiro steps from the canonical value hf/(2e) has been observed. 2. In the IV-curves of double-mesa structures an influence of the current through one mesa on the voltage measured on the other mesa is detected. Both effects can be explained by charge-imbalance on the superconducting layers produced by the quasi-particle current, and can be described successfully by a recently developed theory of nonequilibrium effects in intrinsic Josephson systems.Comment: 8pages, 9figures, submitted to Phys. Rev.

Blechbüchsen von Zink zum Aufbewahren von Vegetabilien

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Infekcyjne zapalenie wsierdzia wywołane przez Streptococcus anginosus z następowym wypruciem zastawki aortalnej i wegetacją zastawki mitralnej u pacjenta po wymianie zastawek mitralnej i aortalnej na protezy biologiczne

Infective endocarditis (IE) is defined as an infection of the endocardial surface of the heart, which may include one or more heart valves. Its intracardiac effects include severe valvular insufficiency, which may lead to intractable congestive heart failure. It is estimated that mortality reaches approximately 15% in previously normal native heart valves and equals 60% in artificial heart valves infections. Taking into account the above mentioned fact, every patient after valve surgery needs special attention to prevent infections. It is not a rare case that formally trivial infection causes drastic consequences leading to repeated cardiac surgery. We present a case of patient with prosthetic mitral and aortic valves, in which prior subclinical infection with Streptococcus anginosus led to severe mitral valve regurgitation with the coexisting mitral valve vegetation and a concomitant paravalvular aortic leak.Zapalenie wsierdzia (IE) zdefiniowano jako zakażenie warstwy wyściełającej wewnętrzną powierzchnię serca, które może obejmować jedną lub więcej zastawek serca. Jego skutki wewnątrzsercowe obejmują ciężką niedomykalność zastawki, co może prowadzić do opornej na leczenie niewydolności serca. Ocenia się, że śmiertelność sięga 15% w zakażeniach wcześniej zdrowych zastawek serca i 60% w przypadku zakażenia sztucznych protez zastawkowych. Ze względu na powyższe każdy chory po operacji zastawkowej wymaga szczególnej uwagi i prewencji przed zakażeniami. Często zdarza się, że z pozoru błaha infekcja powoduje drastyczne następstwa prowadzące do ponownej interwencji kardiochirurgicznej. Opisano przypadek pacjenta z wszczepioną sztuczną zastawką w pozycjach mitralnej oraz aortalnej, u którego niewielka infekcja Streptococcus anginosus doprowadziła do niedomykalności mitralnej z wegetacją zastawki mitralnej oraz współistniejącym przeciekiem okołozastawkowym aortalnym

Mating plugs in polyandrous giants: Which sex produces them, when, how and why?

10.1371/journal.pone.0040939PLoS ONE77

Vestibular disease in dogs: association between neurological examination, MRI lesion localisation and outcome.

OBJECTIVES To determine whether the neurological examination correctly distinguishes between central and peripheral vestibular lesions in dogs. MATERIALS AND METHODS Retrospective study on dogs with vestibular disease presenting to two referral clinics in Germany. RESULTS Ninety-three dogs were included; neurological examination suggested central vestibular disease in 62 and a peripheral lesion in 31. MRI diagnosis was central vestibular disease in 68 dogs and peripheral in 25. Of the 62 dogs with a lesion localisation diagnosed as central vestibular by neurological exam, 61 were correctly identified (98.4%). Twenty-four of the 31 dogs diagnosed with a peripheral lesion by neurological exam had a consistent lesion on MRI (77.4%). CLINICAL SIGNIFICANCE The neurological examination is efficient at identifying lesions in the central vestibular system but less so for peripheral lesions. Therefore it is prudent to recommend imaging in dogs that show signs of peripheral vestibular syndrome but do not rapidly respond to treatment

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Atypical Neurophysiology Underlying Episodic and Semantic Memory in Adults with Autism Spectrum Disorder

Individuals with autism spectrum disorder (ASD) show atypicalities in episodic memory (Boucher et al. in Psychological Bulletin, 138 (3), 458-496, 2012). We asked participants to recall the colours of a set of studied line drawings (episodic judgement), or to recognize line drawings alone (semantic judgement). Cycowicz et al. (Journal of Experimental Child Psychology, 65, 171-237, 2001) found early (300 ms onset) posterior old-new event-related potential effects for semantic judgements in typically developing (TD) individuals, and occipitally focused negativity (800 ms onset) for episodic judgements. Our results replicated findings in TD individuals and demonstrate attenuated early old-new effects in ASD. Late posterior negativity was present in the ASD group, but was not specific to this time window. This non-specificity may contribute to the atypical episodic memory judgements characteristic of individuals with ASD