Usefulness of the ManageMed Screen (MMS) and the Screening for Self-Medication Safety Post Stroke (S5) for Assessing Medication Management Capacity for Clients Post-Stroke

Occupational therapists need to efficiently and accurately screen a client’s medication management capacity, especially for clients post-stroke. Most therapists are not aware of, nor do they utilize specific assessments for, medication management capacity. The purpose of this pilot study was to compare the results of the ManageMed Screen (MMS), the Screening for Self-Medication Safety Post Stroke (S5), and the Montreal Assessment of Cognition (MoCA) on a population of rehabilitation clients post-stroke to determine the usefulness of the medication assessment tools in clinical practice. These screens were designed for use in occupational therapy practice among other healthcare professions: the MMS was validated for the general adult population, the S5 for clients post-stroke, and the MoCA is a cognitive screen used with adult clients with a variety of diagnoses including stroke. The MoCA was used to explore the potential relationship between cognition and medication management capacity. Study participants included five clients post-stroke and three occupational therapists. Clients were screened by the occupational therapists with the MMS, S5, and MoCA, and clinicians also participated in a focus group to assess their perceived usefulness of the screens. Results demonstrated that the MMS score compared to the S5 score was not statistically significant (r=.671, p=.215). There is no established consistency between the MoCA and MMS given these five clients. The MMS score was correlated to the MoCA score and was not found to be significant at a value of .205 with p=.741. The S5 score was also correlated to the MoCA score using SPSS and was found to have a non-significant value of -.287 and p=.640. Additionally, through a focus group, clinicians deemed both the MMS and S5 as useful, but felt the MMS was a more useful screen for their clinical practice with regard to efficient and practical use with clients post-stroke in a rehabilitation setting

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.

Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, including the "CrossMab" format. CrossMabs contain a domain crossover in one of the antigen-binding (Fab) parts, together with the "knobs-and-holes" approach, to enforce the correct assembly of four different polypeptide chains into an IgG-like bispecific antibody. We determined the crystal structure of a hAng-2-binding Fab in its crossed and uncrossed form and show that CH1-CL-domain crossover does not induce significant perturbations of the structure and has no detectable influence on target binding

Antimicrobial resistance of Escherichia coli and Enterococcus faecalis in housed laying-hen flocks in Europe

The aim of this study was to determine the potential association between housing type and multiple drug resistance (MDR) in Escherichia coli and Enterococcus faecalis isolates recovered from 283 laying-hen flocks. In each flock, a cloacal swab from four hens was collected and produced 1102 E. coli and 792 E. faecalis isolates. Broth microdilution was used to test susceptibility to antimicrobials. Country and housing type interacted differently with the MDR levels of both species. In the E. coli model, housing in a raised-floor system was associated with an increased risk of MDR compared to the conventional battery system [odds ratio (OR) 2·12, 95% confidence interval (CI) 1·13-3·97)]. In the E. faecalis model the MDR levels were lower in free-range systems than in conventional battery cages (OR 0·51, 95% CI 0·27-0·94). In Belgium, ceftiofur-resistant E. coli isolates were more numerous than in the other countrie

Converting multilevel nonclassicality into genuine multipartite entanglement

Characterizing genuine quantum resources and determining operational rules for their manipulation are crucial steps to appraise possibilities and limitations of quantum technologies. Two such key resources are nonclassicality, manifested as quantum superposition between reference states of a single system, and entanglement, capturing quantum correlations among two or more subsystems. Here we present a general formalism for the conversion of nonclassicality into multipartite entanglement, showing that a faithful reversible transformation between the two resources is always possible within a precise resource-theoretic framework. Specializing to quantum coherence between the levels of a quantum system as an instance of nonclassicality, we introduce explicit protocols for such a mapping. We further show that the conversion relates multilevel coherence and multipartite entanglement not only qualitatively, but also quantitatively, restricting the amount of entanglement achievable in the process and in particular yielding an equality between the two resources when quantified by fidelity-based geometric measures

Leadership training to improve adenoma detection rate in screening colonoscopy: A randomised trial

Objective Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared t

Living near Main Streets and Respiratory Symptoms in Adults: The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults

The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), conducted in 1991 (SAPALDIA 1) in eight areas among 9,651 randomly selected adults aged 18-60 years, reported associations among the prevalence of respiratory symptoms, nitrogen dioxide, and particles with an aerodynamic diameter of less than 10 μg/m3. Later, 8,047 subjects reenrolled in 2002 (SAPALDIA 2). The effects of individually assigned traffic exposures on reported respiratory symptoms were estimated, while controlling for socioeconomic and exposure- and health-related factors. The risk of attacks of breathlessness increased for all subjects by 13% (95% confidence interval: 3, 24) per 500-m increment in the length of main street segments within 200 m of the home and decreased in never smokers by 12% (95% confidence interval: 0, 22) per 100-m increment in distance from home to a main street. Living within 20 m of a main street increased the risks of regular phlegm by 15% (95% confidence interval: 0, 31) and wheezing with breathing problems by 34% (95% confidence interval: 0, 79) in never smokers. In 2002, the effects related to road distance were different from those in 1991, which could be due to changes in the traffic pollution mixture. These findings among a general population provide strong confirmation that living near busy streets leads to adverse respiratory health effect

Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale

Data from 3691 dairy cows from 76 farms were used to investigate the risk factors associated with area of hair loss over the lateral aspect of the hock, and the correlation between the area of hair loss as calculated using a hock map and hock lesion scores determined using a pre-existing categorical scale. Six factors were associated with a greater area of hair loss, including cows with locomotion score 3, a cleanliness score (10-18/28), high daily milk yield (25.1 - 58.1 kg), poor body condition score (1-1.5), duration of winter housing (≥41 days) and some combinations of cubicle base and bedding materials. Compared with cows housed in cubicles with a concrete base and whole straw or rape straw bedding, cows housed in cubicles with concrete bases with sand or chopped straw bedding had smaller areas of hair loss and cows housed on a mattress base with whole straw or rape straw bedding had a larger area of hair loss. Area of hair loss, as measured on hock maps, was not significantly different between cows with score 1 (median=23.6 cm2) and score 2 (median=20.3 cm2) on the categorical scale for hock lesions. This suggests that the categorical scale was not reflecting the extent of hair loss and that hock maps are a good alternative for studying the dynamics of hock lesions over time. Further work is required to explore the aetiology of hock lesions and find better ways to control this common condition. Keywords: Hock lesions; Hair loss; Dairy cow; Welfare; Hock map

Using eCognition Definiens for automated detection of snow avalanche deposits from very high resolution optical imagery - New developments

The identification of snow avalanche deposits from high resolution optical satellite imagery had been the focus of the project "avalRS” which NGI, together with the Norwegian Computing Centre and Statens Veivesen, had carried out for the European Space Agency (2008-2011; e.g., Frauenfelder et al., 2011). The algorithms developed have produced variable results, often working well in certain situations and poorly in others. In 2011 using the object oriented image processing software eCognition, NGI developed two prototype algorithms on its own. The two algorithms were developed for (i) QuickBird satellite imagery, and (ii) Leica ADS-40 airborne imagery (cf. Lato and Frauenfelder, 2012).Aspart of the continuation of this research program, the algorithms developed in 2011 were published in the journal *Natural Hazards and Earth System Sciences* (Lato et al., 2012a) as well as presented at International conferences, e.g., at the "International Snow Science Workshop 2012” in Anchorage, Alaska (Lato et al., 2012b). Overall the developments have been accepted well within the community, the preliminary results demonstrate the possibility of numerous research and commercial applications. In parallel with the publication and presentation of the research results in 2012, new satellite images containing snow avalanche deposits were tested with the algorithms in eCognition. An overview of the data, the region it represents, as well as a discussion of the results is included in this document.Norges vassdrags- og energidirektorat (NVE), Region Ves

Using eCognition Definiens for automated detection of snow avalanches from optical imagery

Detection of avalanches from remotely collected optical imagery has been tested through analysis of image properties such as brightness, contrast, and different measures of texture. There have been few publications on the subject, providing an excellent opportunity for new developments. The work conducted at NGI in 2011 aimed at detecting fresh snow avalanches from very-high resolution (VHR) optical imagery. The research presented in this Technical Note has been supported by the Ministry of Petroleum and Energy (OED) through the Norwegian Water Resources and Energy Directorate (NVE).Norges Forskningsråd (NFR

The genomes of two key bumblebee species with primitive eusocial organization

Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation