CLINICAL CASE: CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN A CHILD

The article deals with a rare clinical case of chronic thromboembolic pulmonary hypertension in children. This case demonstrates the difficulty of identifying of chronic thromboembolic pulmonary hypertension and masking it under the community-acquired pneumonia. In the diagnosis of the leading methods were echocardiography of the heart and radiopaque tomography of the chest. Etiology of the disease has been established. The use of anticoagulants in the treatment led to positive dynamics: to re radiopaque tomography of the chest imaging of blood clots is not more than 1 mm, decrease in pulmonary artery pressure

Synthesis of 5-Hydroxyectoine from Ectoine: Crystal Structure of the Non-Heme Iron(II) and 2-Oxoglutarate-Dependent Dioxygenase EctD

As a response to high osmolality, many microorganisms synthesize various types of compatible solutes. These organic osmolytes aid in offsetting the detrimental effects of low water activity on cell physiology. One of these compatible solutes is ectoine. A sub-group of the ectoine producer's enzymatically convert this tetrahydropyrimidine into a hydroxylated derivative, 5-hydroxyectoine. This compound also functions as an effective osmostress protectant and compatible solute but it possesses properties that differ in several aspects from those of ectoine. The enzyme responsible for ectoine hydroxylation (EctD) is a member of the non-heme iron(II)-containing and 2-oxoglutarate-dependent dioxygenases (EC 1.14.11). These enzymes couple the decarboxylation of 2-oxoglutarate with the formation of a high-energy ferryl-oxo intermediate to catalyze the oxidation of the bound organic substrate. We report here the crystal structure of the ectoine hydroxylase EctD from the moderate halophile Virgibacillus salexigens in complex with Fe3+ at a resolution of 1.85 Å. Like other non-heme iron(II) and 2-oxoglutarate dependent dioxygenases, the core of the EctD structure consists of a double-stranded β-helix forming the main portion of the active-site of the enzyme. The positioning of the iron ligand in the active-site of EctD is mediated by an evolutionarily conserved 2-His-1-carboxylate iron-binding motif. The side chains of the three residues forming this iron-binding site protrude into a deep cavity in the EctD structure that also harbours the 2-oxoglutarate co-substrate-binding site. Database searches revealed a widespread occurrence of EctD-type proteins in members of the Bacteria but only in a single representative of the Archaea, the marine crenarchaeon Nitrosopumilus maritimus. The EctD crystal structure reported here can serve as a template to guide further biochemical and structural studies of this biotechnologically interesting enzyme family

Research on the contribution of the nobel prize laureates in physics to the development of modern equipment and technologies in technical universities

© 2014, Ecozone, OAIMDD. All rights reserved. The article is devoted to the significance of the study of Nobel laureates in Physics in the development of technology contribution by the students of technical institutions. The basic information about the Nobel laureates in the field of Technical physics is presented. There are traced the basic physical ideas that have established their use in various technical devices and technologies. Particular attention is paid to physical discoveries that determined the form of the late twentieth century technology, in such areas as spectroscopy, laser technology and electronics. The main achievements from the twentieth century and the beginning of the XXI century have also been regarded

Research on the contribution of the nobel prize laureates in physics to the development of modern equipment and technologies in technical universities

© 2014, Ecozone, OAIMDD. All rights reserved. The article is devoted to the significance of the study of Nobel laureates in Physics in the development of technology contribution by the students of technical institutions. The basic information about the Nobel laureates in the field of Technical physics is presented. There are traced the basic physical ideas that have established their use in various technical devices and technologies. Particular attention is paid to physical discoveries that determined the form of the late twentieth century technology, in such areas as spectroscopy, laser technology and electronics. The main achievements from the twentieth century and the beginning of the XXI century have also been regarded

Research on the contribution of the nobel prize laureates in physics to the development of modern equipment and technologies in technical universities

© 2014, Ecozone, OAIMDD. All rights reserved. The article is devoted to the significance of the study of Nobel laureates in Physics in the development of technology contribution by the students of technical institutions. The basic information about the Nobel laureates in the field of Technical physics is presented. There are traced the basic physical ideas that have established their use in various technical devices and technologies. Particular attention is paid to physical discoveries that determined the form of the late twentieth century technology, in such areas as spectroscopy, laser technology and electronics. The main achievements from the twentieth century and the beginning of the XXI century have also been regarded

Automation of processes of management of residential complexes and business centers on the basis of digital technologies

The theme of the master's thesis: automation of processes of management of residential complexes and business centers based on digital technologies. The relevance of this thesis is due to the increasing role of automation of information systems in all sectors, including in the field of management of residential buildings. The ability to implement developments on this subject can not only improve the efficient use of resources, but also qualitatively affect the lives of citizens. The purpose of the master's thesis is to develop a model of automation of projects of management of residential complexes and business centers based on digital technologies. To achieve this goal, the following tasks were performed: - studied the theoretical issues of automation in the management of real estate; - product requirements are formed from the point of view of the management company; - the analysis of the feasibility of product implementation for the management company; - estimated economic efficiency. The object of research is an automated control system of residential complexes and business centers. The subject of research is the management of residential buildings and business centers.Актуальность данной диссертации обусловлена возрастающей ролью автоматизации информационных систем во всех отраслях, в том числе и в области управления жилыми зданиями. Возможность реализации наработок по данной тематике может способствовать не только повышению эффективного использования ресурсов, но и качественно повлиять на жизнь граждан. Целью магистерской диссертации является разработка модели автоматизации проектов управления жилыми комплексами и бизнес-центрами на основе цифровых технологий. Для выполнения этой цели были выполнены следующие задачи: - изучены теоретические вопросы автоматизации при управлении объектами недвижимости; - сформированы требования к продукту с точки зрения управляющей компании; - проведен анализ целесообразности внедрения продукта для управляющей компании; - оценена экономическая эффективность. Объект исследования – автоматизированная система управления жилыми комплексами и бизнес-центрами. Предмет исследования ‒ процессы управления жилыми домами и бизнес-центрами

On a Hyperbolic Equation for the Rayleigh Wave

A 1D hyperbolic equation is derived for the Rayleigh wave induced by prescribed surface loading. The wave operator turns out to be independent of the vertical coordinate, which appears only in the right hand side of the equation as a parameter within the pseudo-differential operator acting on the given load. It is shown that in case of the classical 2D Lamb problem this operator causes smoothening of the surface concentrated impulse as the depth increases. The suggested formulation enables revealing of the peculiarities of surface elastic wave

Arbitrage « médical ». Appréciation de l'étendue d'un préjudice corporel par le médecin arbitre. Compromis d'arbitrage. Consentement de la victime du préjudice. Absence d'obligation de conseil de l'assureur

International audience(Paris, 17e ch., 19 mai 1999, inédit, Benson c/ MACIF Ile-de-France