A Latent Variable Approach to Multivariate Quantitative Trait Loci

A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and qualitative traits (including count data and censored traits) in a single modelling framework. In the framework, the observations are modelled as functions of latent variables, which are then affected by quantitative trait loci. Separating the analysis in this way means that measurement errors in the phenotypic observations can be included easily in the model, providing robust inferences. The performance of the method is illustrated using two real multivariate datasets, from barley and Scots pine

FReD: The floral reflectance spectra database

Floral reflectance measurements are of great value to researchers who need consider the real colour of flowers, for example in the context of how the flowers appear to their pollinators. We have thus developed the Floral Reflectance Database (FReD) to assist these researchers, gathering together floral reflectance data in a publicly available, searchable online database. The first version of the database is now available online at "http://www.reflectance.co.uk":http://www.reflectance.co.uk. We anticipate that this resource will be of interest to researchers working on flower colour and animal vision

Exposure to glycols and their renal effects in motor servicing workers

Ten car mechanics frequently exposed to glycol-based cooling liquids were followed during a workshift. Airborne ethylene and propylene glycol concentrations in the car mechanics' environment were measured. The car mechanics gave urine samples after the workshift and their excretion of ethylene glycol, propylene glycol, oxalic acid, calcium and ammonia was analysed and compared to that of unexposed office workers. Urinary succinate dehydrogenase activity and glycosaminoglycans were also measured in both groups. Airborne ethylene and propylene glycol concentrations in the car mechanics' environment were negligible. Urinary ethylene glycol excretion in exposed workers was significantly higher than that in unexposed workers, but propylene glycol excretion was at the same level as in controls. In the exposed group, the excretion of the end metabolite of ethylene glycol, oxalic acid (47 ± 11 mmol/mol creatinine, mean ± SD, n= 10) differed slightly from that of controls (36 ± 14 mmol/mol creatinine, mean ± SD, n= 10). Urinary excretion of ammonia was higher among exposed workers than office workers. The excretion of calcium did not differ from that of controls. A marginally decreased urinary succinate dehydrogenase activity was found in the exposed men. The excretion of glycosaminoglycans was significantly lower in exposed workers. Therefore, it seems that ethylene glycol is absorbed by skin contact. The internal body burden is associated with oxaluria and increased ammoniagenesis typical of chronic acidosi

Turnstile behaviour of the Cooper-pair pump

We have experimentally studied the behaviour of the so-called Cooper pair pump (CPP) with three Josephson junctions, in the limit of small Josephson coupling EJ < EC. These experiments show that the CPP can be operated as a traditional turnstile device yielding a gate-induced current 2ef in the direction of the bias voltage, by applying an RF-signal with frequency f to the two gates in phase, while residing at the degeneracy node of the gate plane. Accuracy of the CPP during this kind of operation was about 3% and the fundamental Landau-Zener limit was observed to lie above 20 MHz. We have also measured the current pumped through the array by rotating around the degeneracy node in the gate plane. We show that this reproduces the turnstile-kind of behavior. To overcome the contradiction between the obtained e-periodic DC-modulation and a pure 2e-behaviour in the RF-measurements, we base our observations on a general principle that the system always minimises its energy. It suggests that if the excess quasiparticles in the system have a freedom to tunnel, they will organize themselves to the configuration yielding the highest current.Comment: 29 pages, 16 figures, uses REVTeX and graphicx-packag

Naisen rasvakudoksen endokrinologiaa - steroidihormonimetabolian yhteys rintasyöpään

Rasva­kudos on eli­mis­tömme suu­rin endok­rii­ninen elin. Hormo­naa­linen sää­tely vai­kuttaa rasva­ku­doksen toi­mintaan ja kerty­miseen, jo­ka on eri­laista nai­silla ja mie­hillä se­kä ke­hon eri osissa. Rasva­kudos on myös merkit­tävä ste­roi­di­hor­monien läh­de, etenkin ­vaih­de­vuosien jäl­keen. Li­havuus ai­heuttaa rasva­ku­doksen toimin­nassa muu­toksia, muun muas­sa kroo­nisen tuleh­dus­reaktion. Häi­riöt rasva­ku­doksen toimin­nassa voi­vat ol­la yhtey­dessä kroo­nisten sai­rauksien, ku­ten rinta­syövän, ­dia­be­teksen se­kä sy­dän- ja veri­suo­ni­tautien syn­tyyn ja nii­den pahe­ne­miseen. Rasva­ku­doksen hormo­ni­toi­minnan ja rasva­so­lujen tuot­tamien välit­tä­jäai­neiden, adi­po­kiinien, tutki­minen aut­taa ymmär­tämään pa­remmin liha­vuuteen liit­tyvien sai­rauksien pato­fy­sio­logiaa ja luo uu­sia hoito­mah­dol­li­suuksia.Peer reviewe

The connection between the radio jet and the gamma-ray emission in the radio galaxy 3C 120

We present the analysis of the radio jet evolution of the radio galaxy 3C 120 during a period of prolonged gamma-ray activity detected by the Fermi satellite between December 2012 and October 2014. We find a clear connection between the gamma-ray and radio emission, such that every period of gamma-ray activity is accompanied by the flaring of the mm-VLBI core and subsequent ejection of a new superluminal component. However, not all ejections of components are associated with gamma-ray events detectable by Fermi. Clear gamma-ray detections are obtained only when components are moving in a direction closer to our line of sight.This suggests that the observed gamma-ray emission depends not only on the interaction of moving components with the mm-VLBI core, but also on their orientation with respect to the observer. Timing of the gamma-ray detections and ejection of superluminal components locate the gamma-ray production to within almost 0.13 pc from the mm-VLBI core, which was previously estimated to lie about 0.24 pc from the central black hole. This corresponds to about twice the estimated extension of the broad line region, limiting the external photon field and therefore suggesting synchrotron self Compton as the most probable mechanism for the production of the gamma-ray emission. Alternatively, the interaction of components with the jet sheath can provide the necessary photon field to produced the observed gamma-rays by Compton scattering.Comment: Already accepted for publication in The Astrophysical Journa

The Parsec-scale Structure, Kinematics, and Polarization of Radio-Loud Narrow-Line Seyfert 1 Galaxies

Several narrow-line Seyfert 1 galaxies (NLS1s) have now been detected in gamma rays, providing firm evidence that at least some of this class of active galactic nuclei (AGN) produce relativistic jets. The presence of jets in NLS1s is surprising, as these sources are typified by comparatively small black hole masses and near- or super-Eddington accretion rates. This challenges the current understanding of the conditions necessary for jet production. Comparing the properties of the jets in NLS1s with those in more familiar jetted systems is thus essential to improve jet production models. We present early results from our campaign to monitor the kinematics and polarization of the parsec-scale jets in a sample of 15 NLS1s through multifrequency observations with the Very Long Baseline Array. These observations are complemented by fast-cadence 15 GHz monitoring with the Owens Valley Radio Observatory 40m telescope and optical spectroscopic monitoring with with the 2m class telescope at the Guillermo Haro Astrophysics Observatory in Cananea, Mexico.Comment: 4 pages, 1 figure. To appear in the Proceedings of the IAU Symposium No. 313: "Extragalactic jets from every angle," Galapagos, Ecuador, 15-19 September 2014, F. Massaro, C. C. Cheung, E. Lopez, and A. Siemiginowska (Eds.), Cambridge University Pres

Causal connection in parsec-scale relativistic jets: results from the MOJAVE VLBI survey

We report that active galactic nucleus (AGN) jets are causally connected on parsec scales, based on 15 GHz Very Long Baseline Array (VLBA) data from a sample of 133 AGN jets. This result is achieved through a new method for measuring the product of the jet Lorentz factor and the intrinsic opening angle Gamma*theta_j from measured apparent opening angles in flux density limited samples of AGN jets. The Gamma*theta_j parameter is important for jet physics because it is related to the jet-frame sidewise expansion speed and causal connection between the jet edges and its symmetry axis. Most importantly, the standard model of jet production requires that the jet be causally connected with its symmetry axis, implying that Gamma*theta_j < 1. When we apply our method to the MOJAVE flux density limited sample of radio loud objects, we find Gamma*theta_j = 0.2, implying that AGN jets are causally connected. We also find evidence that AGN jets viewed very close to the line of sight effectively have smaller intrinsic opening angles compared with jets viewed more off-axis, which is consistent with Doppler beaming and a fast inner spine/slow outer sheath velocity field. Notably, gamma-ray burst (GRB) jets have a typical Gamma*theta_j that is two orders of magnitude higher, suggesting that different physical mechanisms are at work in GRB jets compared to AGN jets. A useful application of our result is that a jet's beaming parameters can be derived. Assuming Gamma*theta_j is approximately constant in the AGN jet population, an individual jet's Doppler factor and Lorentz factor (and therefore also its viewing angle) can be determined using two observable quantities: apparent jet opening angle and the apparent speed of jet components.Comment: 9 pages, 4 figure