Non-Gaussianity in the HILC foreground-reduced three-year WMAP CMB map

A detection or nondetection of primordial non-Gaussianity in the CMB data is essential not only to test alternative models of the physics of the early universe but also to discriminate among classes of inflationary models. Given this far reaching consequences of such a non-Gaussianity detection for our understanding of the physics of the early universe, it is important to employ alternative indicators in order to have further information about the Gaussianity features of CMB that may be helpful for identifying their origins. In this way, a considerable effort has recently gone into the design of non-Gaussianity indicators, and in their application in the search for deviation from Gaussianity in the CMB data. Recently we have proposed two new large-angle non-Gaussianity indicators which provide measures of the departure from Gaussianity on large angular scales. We have used these indicators to carry out analyses of Gaussianity of the single frequency bands and of the available foreground-reduced {\it five-year} maps with and without the KQ75 mask. Here we extend and complement these studies by performing a new analysis of deviation from Gaussianity of the {\it three-year} harmonic ILC (HILC) foreground-reduced full-sky and KQ75 masked maps obtained from WMAP data. We show that this full-sky foreground-reduced maps presents a significant deviation from Gaussianity, which is brought down to a level of consistency with Gaussianity when the KQ75 mask is employed.Comment: 6 pages, 1 figure. To appear in IJMPD (2010). V2: Corrected ref.[8]

A Study of Gaussianity in CMB band maps

The detection of non-Gaussianity in the CMB data would rule out a number of inflationary models. A null detection of non-Gaussianity, instead, would exclude alternative models for the early universe. Thus, a detection or non-detection of primordial non-Gaussianity in the CMB data is crucial to discriminate among inflationary models, and to test alternative scenarios. However, there are various non-cosmological sources of non-Gaussianity. This makes important to employ different indicators in order to detect distinct forms of non-Gaussianity in CMB data. Recently, we proposed two new indicators to measure deviation from Gaussianity on large angular scales, and used them to study the Gaussianity of the raw band WMAP maps with and without the KQ75 mask. Here we extend this work by using these indicators to perform similar analyses of deviation from Gaussianity of the foreground-reduced Q, V, and W band maps. We show that there is a significant deviation from Gaussianity in the considered full-sky maps, which is reduced to a level consistent with Gaussianity when the KQ75 mask is employed.Comment: 5 pages, 2 PS figures, uses ws-ijmpd.cls ; to be published in the International Journal of Modern Physics

An interface to retrieve personal memories using an iconic visual language

Relevant past events can be remembered when visualizing related pictures. The main difficulty is how to find these photos in a large personal collection. Query definition and image annotation are key issues to overcome this problem. The former is relevant due to the diversity of the clues provided by our memory when recovering a past moment and the later because images need to be annotated with information regarding those clues to be retrieved. Consequently, tools to recover past memories should deal carefully with these two tasks. This paper describes a user interface designed to explore pictures from personal memories. Users can query the media collection in several ways and for this reason an iconic visual language to define queries is proposed. Automatic and semi-automatic annotation is also performed using the image content and the audio information obtained when users show their images to others. The paper also presents the user interface evaluation based on tests with 58 participants

Severe Mycoplasma hominis Infections in Two Renal Transplant Patients

Systemic infections due to Mycoplasma hominis are rare and occur mainly in immunocompromised patients. Reported here are the cases of two renal transplant patients with peritonitis who did not respond to empirical antimicrobial treatment. Effective treatment with doxycycline was administered only after definitive identification of Mycoplasma hominis was achieved. For this identification, the new genetic amplification-sequencing method was invaluabl

Spatial mapping of band bending in semiconductor devices using in-situ quantum sensors

Band bending is a central concept in solid-state physics that arises from local variations in charge distribution especially near semiconductor interfaces and surfaces. Its precision measurement is vital in a variety of contexts from the optimisation of field effect transistors to the engineering of qubit devices with enhanced stability and coherence. Existing methods are surface sensitive and are unable to probe band bending at depth from surface or bulk charges related to crystal defects. Here we propose an in-situ method for probing band bending in a semiconductor device by imaging an array of atomic-sized quantum sensing defects to report on the local electric field. We implement the concept using the nitrogen-vacancy centre in diamond, and map the electric field at different depths under various surface terminations. We then fabricate a two-terminal device based on the conductive two-dimensional hole gas formed at a hydrogen-terminated diamond surface, and observe an unexpected spatial modulation of the electric field attributed to a complex interplay between charge injection and photo-ionisation effects. Our method opens the way to three-dimensional mapping of band bending in diamond and other semiconductors hosting suitable quantum sensors, combined with simultaneous imaging of charge transport in complex operating devices.Comment: This is a pre-print of an article published in Nature Electronics. The final authenticated version is available online at https://dx.doi.org/10.1038/s41928-018-0130-

Cloud Atlas: Weak Color Modulations Due to Rotation in the Planetary-mass Companion GU Psc b and 11 Other Brown Dwarfs

Among the greatest challenges in understanding ultracool brown dwarf and exoplanet atmospheres is the evolution of cloud structure as a function of temperature and gravity. In this study, we present the rotational modulations of GU Psc b—a rare mid-T spectral type planetary-mass companion at the end of the L/T spectral type transition. Based on the Hubble Space Telescope/WFC3 1.1–1.67 μm time-series spectra, we observe a quasi-sinusoidal light curve with a peak-to-trough flux variation of 2.7% and a minimum period of 8 h. The rotation-modulated spectral variations are weakly wavelength-dependent, or largely gray between 1.1 and 1.67 μm. The gray modulations indicate that heterogeneous clouds are present in the photosphere of this low-gravity mid-T dwarf. We place the color and brightness variations of GU Psc b in the context of rotational modulations reported for mid-L to late-T dwarfs. Based on these observations, we report a tentative trend: mid-to-late T dwarfs become slightly redder in J − H color with increasing J-band brightness, while L dwarfs become slightly bluer with increasing brightness. If this trend is verified with more T-dwarf samples, it suggests that in addition to the mostly gray modulations, there is a second-order spectral-type dependence on the nature of rotational modulations

Cloud Atlas: High-Contrast Time-Resolved Observations of Planetary-Mass Companions

Directly-imaged planetary-mass companions offer unique opportunities in atmospheric studies of exoplanets. They share characteristics of both brown dwarfs and transiting exoplanets, therefore, are critical for connecting atmospheric characterizations for these objects. Rotational phase mapping is a powerful technique to constrain the condensate cloud properties in ultra-cool atmospheres. Applying this technique to directly-imaged planetary-mass companions will be extremely valuable for constraining cloud models in low mass and surface gravity atmospheres and for determining the rotation rate and angular momentum of substellar companions. Here, we present Hubble Space Telescope Wide Field Camera 3 near-infrared time-resolved photometry for three planetary-mass companions, AB Pic B, 2M0122B, and 2M1207b. Using two-roll differential imaging and hybrid point spread function modeling, we achieve sub-percent photometric precision for all three observations. We find tentative modulations ($<\!\!2\sigma$) for AB Pic B and 2M0122B but cannot reach conclusive results on 2M1207b due to strong systematics. The relatively low significance of the modulation measurements cannot rule out the hypothesis that these planetary-mass companions have the same vertical cloud structures as brown dwarfs. Our rotation rate measurements, combined with archival period measurements of planetary-mass companions and brown dwarfs do not support a universal mass-rotation relation. The high precision of our observations and the high occurrence rates of variable low-surface gravity objects encourage high-contrast time-resolved observations with the James Webb Space Telescope.Comment: Accepted for publication in AAS Journa

Cloud Atlas: High-precision HST/WFC3/IR Time-resolved Observations of Directly Imaged Exoplanet HD 106906b

HD 106906b is an ~11M_(Jup), ~15 Myr old directly imaged exoplanet orbiting at an extremely large distance from its host star. The wide separation (7 11) between HD 106906b and its host star greatly reduces the difficulty in direct-imaging observations, making it one of the most favorable directly imaged exoplanets for detailed characterization. In this paper, we present HST/WFC3/IR time-resolved observations of HD 106906b in the F127M, F139M, and F153M bands. We have achieved ~1% precision in the lightcurves in all three bands. The F127M lightcurve demonstrates marginally detectable (2.7σ significance) variability with a best-fitting period of 4 hr, while the lightcurves in the other two bands are consistent with flat lines. We construct primary-subtracted deep images and use these images to exclude additional companions to HD 106906 that are more massive than 4 M_(Jup) and locate at projected distances of more than ~500 au. We measure the astrometry of HD 106906b in two HST/WFC3 epochs and achieve precisions better than 2.5 mas. The position angle and separation measurements do not deviate from those in the 2004 HST/ACS/HRC images for more than 1σ uncertainty. We provide the HST/WFC3 astrometric results for 25 background stars that can be used as reference sources in future precision astrometry studies. Our observations also provide the first 1.4 μm water band photometric measurement for HD 106906b. HD 106906b's spectral energy distribution and the best-fitting BT-Settl model have an inconsistency in the 1.4 μm water absorption band, which highlights the challenges in modeling atmospheres of young planetary-mass objects

Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model

Bovine genital campylobacteriosis (BGC), caused by Campylobacter fetus subsp. venerealis, is associated with production losses in cattle worldwide. This study aimed to develop a reliable BGC guinea pig model to facilitate future studies of pathogenicity, abortion mechanisms and vaccine efficacy. Seven groups of five pregnant guinea pigs (1 control per group) were inoculated with one of three strains via intraperitoneal (IP) or intra-vaginal routes. Samples were examined using culture, PCR and histology. Abortions ranged from 0% to 100% and re-isolation of causative bacteria from sampled sites varied with strain, dose of bacteria and time to abortion. Histology indicated metritis and placentitis, suggesting that the bacteria induce inflammation, placental detachment and subsequent abortion. Variation of virulence between strains was observed and determined by culture and abortion rates. IP administration of C fetus subsp. venerealis to pregnant guinea pigs is a promising small animal model for the investigation of BGC abortion. (C) 2014 Elsevier Ltd. All rights reserved

Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons

The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-α1,3-galactose (αGal) xenoantigen on neonatal islet cell clusters (NICC) than on adult pig islets may provoke a stronger reaction, but this has not been tested in the baboon model. Here, we report that WT pig NICC xenografts triggered profound IBMIR in baboons, with intravascular clotting and graft destruction occurring within hours, which was not prevented by anti-thrombin treatment. In contrast, IBMIR was minimal when recipients were immunosuppressed with a clinically relevant protocol and transplanted with NICC from αGal-deficient pigs transgenic for the human complement regulators CD55 and CD59. These genetically modified (GM) NICC were less susceptible to humoral injury in vitro than WT NICC, inducing significantly less complement activation and thrombin generation when incubated with baboon platelet-poor plasma. Recipients of GM NICC developed a variable anti-pig antibody response, and examination of the grafts 1 month after transplant revealed significant cell-mediated rejection, although scattered insulin-positive cells were still present. Our results indicate that IBMIR can be attenuated in this model, but long-term graft survival may require more effective immunosuppression or further donor genetic modification