Study of a Positron Emission Mammograph

Today breast cancer is among the most common causes of death for women. One in eight women will develop a tumour in her breast at least once in her lifetime. An early detection of the cancer is crucial to the patient's survival and recovery. For early detec- tion it is necessary to have an instrument with high spatial resolution and efficiency. The scope of this thesis is two aspects of a dedicated PET scanner for mammography developed by the Crystal Clear Collaboration, the ClearPEM. The first half of the thesis deals with the experimental work on scintillation crystals which constitute the main part of the detector. The second part looks into the design of the whole system and the possibility of future enhancements by adding an ultrasound probe and /or a veto-counter. The effects of these changes are studied by employing simulation tools. The key to excellent detector performance is to use scintillation crystals with properties best matched to the requirements of a given application. To better understand the scintillation characteristics of the crystals, how they are influenced by their production history and how to improve their properties, this study compares scintillation materials of three producers in respect to light yield, decay time and transmission characteristics. The non-proportional response to different photon energies and the intrinsic energy resolution of the scintillation crystals is also studied. In addition to the already mentioned properties scintillation crystals for the ClearPEM detector have to be able to resolve the position of the interaction of the photon in the crystal with high precision. Two different scintillation materials are studied with the ob jective of reaching the necessary depth of interaction resolution. The influence of the surface condition on the depth of interaction resolution is also examined. Two ma jor constraints exist in PET imaging. A PET image shows only the metabolism of the cells in the patient, no morphological information can be obtained. For this purpose an ultrasound probe is going to be integrated into the ClearPEM system. The second issue is organ activity, which is especially relevant in breast imaging because of the closeness of the region of interest to the heart. This is the main source for random coincidences. A veto counter on the patient's back is proposed to reduce the random coincidence rate. A series of Monte Carlo simulations was performed which show the negative and positive changes in sensitivity caused by changes in the scanner geometry necessary to implement the ultrasound probe and random background reduction with the veto-counter

Analytical study of electrical disconnect system for use on manned and unmanned missions

The objective of this contract is to establish an optimum electrical disconnect system design(s) for use on manned and unmanned missions. The purpose of the disconnect system is to electrically mate and demate the spacecraft to subsystem module interfaces to accomplish orbital operations. The results of Task 1 and Task 2 of the effort are presented. Task 1 involves the definition of the functional, operational, and environmental requirements for the connector system to support the leading prototype candidate concepts. Task 2 involves the documentation review and survey of available existing connector designs

Mental health care for irregular migrants in Europe: Barriers and how they are overcome

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Sensitivity to Gravitational Waves from Compact Binary Coalescences Achieved during LIGO's Fifth and Virgo's First Science Run

We summarize the sensitivity achieved by the LIGO and Virgo gravitational wave detectors for compact binary coalescence (CBC) searches during LIGO's fifth science run and Virgo's first science run. We present noise spectral density curves for each of the four detectors that operated during these science runs which are representative of the typical performance achieved by the detectors for CBC searches. These spectra are intended for release to the public as a summary of detector performance for CBC searches during these science runs.Comment: 12 pages, 5 figure

Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics

The Clear-PEM scanner for positron emission mammography under development is described. The detector is based on pixelized LYSO crystals optically coupled to avalanche photodiodes and readout by a fast low-noise electronic system. A dedicated digital trigger (TGR) and data acquisition (DAQ) system is used for on-line selection of coincidence events with high efficiency, large bandwidth and small dead-time. A specialized gantry allows to perform exams of the breast and of the axilla. In this paper we present results of the measurement of detector modules that integrate the system under construction as well as the imaging performance estimated from Monte Carlo simulated data.http://www.sciencedirect.com/science/article/B6TJM-4M942B5-D/1/e8aea93baa1aeae3538ea200a5a5466

Virgo calibration and reconstruction of the gravitational wave strain during VSR1

Virgo is a kilometer-length interferometer for gravitational waves detection located near Pisa. Its first science run, VSR1, occured from May to October 2007. The aims of the calibration are to measure the detector sensitivity and to reconstruct the time series of the gravitational wave strain h(t). The absolute length calibration is based on an original non-linear reconstruction of the differential arm length variations in free swinging Michelson configurations. It uses the laser wavelength as length standard. This method is used to calibrate the frequency dependent response of the Virgo mirror actuators and derive the detector in-loop response and sensitivity within ~5%. The principle of the strain reconstruction is highlighted and the h(t) systematic errors are estimated. A photon calibrator is used to check the sign of h(t). The reconstructed h(t) during VSR1 is valid from 10 Hz up to 10 kHz with systematic errors estimated to 6% in amplitude. The phase error is estimated to be 70 mrad below 1.9 kHz and 6 micro-seconds above.Comment: 8 pages, 8 figures, proceedings of Amaldi 8 conference, to be published in Journal of Physics Conference Series (JPCS). Second release: correct typo

Directional limits on persistent gravitational waves using LIGO S5 science data

The gravitational-wave (GW) sky may include nearby pointlike sources as well as astrophysical and cosmological stochastic backgrounds. Since the relative strength and angular distribution of the many possible sources of GWs are not well constrained, searches for GW signals must be performed in a model-independent way. To that end we perform two directional searches for persistent GWs using data from the LIGO S5 science run: one optimized for pointlike sources and one for arbitrary extended sources. The latter result is the first of its kind. Finding no evidence to support the detection of GWs, we present 90% confidence level (CL) upper-limit maps of GW strain power with typical values between 2-20x10^-50 strain^2 Hz^-1 and 5-35x10^-49 strain^2 Hz^-1 sr^-1 for pointlike and extended sources respectively. The limits on pointlike sources constitute a factor of 30 improvement over the previous best limits. We also set 90% CL limits on the narrow-band root-mean-square GW strain from interesting targets including Sco X-1, SN1987A and the Galactic Center as low as ~7x10^-25 in the most sensitive frequency range near 160 Hz. These limits are the most constraining to date and constitute a factor of 5 improvement over the previous best limits.Comment: 10 pages, 4 figure

Medicine is patriarchal, but alternative medicine is not the answer

Women are over-represented within alternative medicine, both as consumers and as service providers. In this paper, I show that the appeal of alternative medicine to women relates to the neglect of women’s health needs within scientific medicine. This is concerning because alternative medicine is severely limited in its therapeutic effects; therefore, those who choose alternative therapies are liable to experience inadequate healthcare. I argue that while many patients seek greater autonomy in alternative medicine, the absence of an evidence base and plausible mechanisms of action leaves patients unable to realize meaningful autonomy. This seems morally troubling, especially given that the neglect of women’s needs within scientific medicine seems to contribute to preferences for alternative medicine. I conclude that the liberatory credentials of alternative medicine should be questioned and make recommendations to render scientific medicine better able to meet the needs of typical alternative medicine consumers

PRECISE 3D MEASUREMENT WITH STANDARD MEANS AND MINIMIAL USER INTERACTION - EXTENDED SINGLE-VIEW RECONSTRUCTION

The paper proposes a new method for general 3D measurement and 3D point reconstruction. Looking at its features, the method explicitly aims at practical applications. These features especially cover low technical expenses and minimal user interaction, a clear problem separation into steps that are solved by simple mathematical methods (direct, stable and optimal with respect to least error squares), and scalability. The method expects the internal and radial distortion parameters of the used camera(s) as inputs, and a plane quadrangle with known geometry within the scene. At first, for each single picture the 3D position of the reference quadrangle (with respect to each camera coordinate frame) is calculated. These 3D reconstructions of the reference quadrangle are then used to yield the relative external parameters of each camera regarding the first one. With known external parameters, triangulation is finally possible. The differences from other known procedures are outlined, paying attention to the stable mathematical methods (no usage of nonlinear optimization) and the low user interaction with good results at the same time

Stability of optical elements in the NIF target area building

The Target Area Building (TAB) of the National Ignition Facility (NIF) is 300 feet long, 100 feet wide, and 100 feet tall and is comprised of a cylindrical target building and two switchyard space frames. The reinforced concrete target building houses the target chamber, target positioner, turning mirrors, final optics assemblies, and diagnostics, while the steel switchyard space frames support turning mirrors and diagnostic equipment. Within the TAB, the 192 independent laser beams of the NIF laser system are required to be accurately positioned. In order to satisfy the engineering system requirement for optical system positioning (stability on target), the TAB must provide a stable platform for optical elements before and during a shot. This paper summarizes the stability analyses that were performed in support of the TAB and optical system design. Sources that influence optic stability are structural excitations, such as ambient and wind induced vibrations, and thermal transients, such as diurnal and HVAC temperature changes. A positioning error budget has been developed for the NIF project for use in the design and evaluation of structures which support optical elements. To satisfy the error budget requirements, vibrational stability will be achieved through a combination of facility design, optic support structure design, and passive damping. Thermal stability will be accomplished by using high thermal-mass concrete structures, conditioned air flow, and a reduction of heat sources. Finite element analysis has been used to evaluate the design of the TAB and optical support structures. A detailed structural model of the TAB that includes the target positioner, target chamber, turning mirrors, and diagnostics, has been used for stability evaluations. Finite element analyses covering ambient ground vibration, thermal loads, pressure fluctuations, and wind excitations have demonstrated that the current design of the TAB provides a stable platform for maintaining beam alignment