Identification of neural networks that contribute to motion sickness through principal components analysis of fos labeling induced by galvanic vestibular stimulation

Motion sickness is a complex condition that includes both overt signs (e.g., vomiting) and more covert symptoms (e.g., anxiety and foreboding). The neural pathways that mediate these signs and symptoms are yet to identified. This study mapped the distribution of c-fos protein (Fos)-like immunoreactivity elicited during a galvanic vestibular stimulation paradigm that is known to induce motion sickness in felines. A principal components analysis was used to identify networks of neurons activated during this stimulus paradigm from functional correlations between Fos labeling in different nuclei. This analysis identified five principal components (neural networks) that accounted for greater than 95% of the variance in Fos labeling. Two of the components were correlated with the severity of motion sickness symptoms, and likely participated in generating the overt signs of the condition. One of these networks included neurons in locus coeruleus, medial, inferior and lateral vestibular nuclei, lateral nucleus tractus solitarius, medial parabrachial nucleus and periaqueductal gray. The second included neurons in the superior vestibular nucleus, precerebellar nuclei, periaqueductal gray, and parabrachial nuclei, with weaker associations of raphe nuclei. Three additional components (networks) were also identified that were not correlated with the severity of motion sickness symptoms. These networks likely mediated the covert aspects of motion sickness, such as affective components. The identification of five statistically independent component networks associated with the development of motion sickness provides an opportunity to consider, in network activation dimensions, the complex progression of signs and symptoms that are precipitated in provocative environments. Similar methodology can be used to parse the neural networks that mediate other complex responses to environmental stimuli. © 2014 Balaban et al

Emergence of polarized opinions from free association networks

We developed a method that can identify polarized public opinions by finding modules in a network of statistically related free word associations. Associations to the cue “migrant” were collected from two independent and comprehensive samples in Hungary (N1 = 505, N2 = 505). The co-occurrence-based relations of the free word associations reflected emotional similarity, and the modules of the association network were validated with well-established measures. The positive pole of the associations was gathered around the concept of “Refugees” who need help, whereas the negative pole associated asylum seekers with “Violence”. The results were relatively consistent in the two independent samples. We demonstrated that analyzing the modular organization of association networks can be a tool for identifying the most important dimensions of public opinion about a relevant social issue without using predefined constructs

Rapid glaciation and a two-step sea-level plunge into The Last Glacial Maximum

The approximately 10,000-year-long Last Glacial Maximum, before the termination of the last ice age, was the coldest period in Earth’s recent climate history1. Relative to the Holocene epoch, atmospheric carbon dioxide was about 100 parts per million lower and tropical sea surface temperatures were about 3 to 5 degrees Celsius lower2,3. The Last Glacial Maximum began when global mean sea level (GMSL) abruptly dropped by about 40 metres around 31,000 years ago4 and was followed by about 10,000 years of rapid deglaciation into the Holocene1. The masses of the melting polar ice sheets and the change in ocean volume, and hence in GMSL, are primary constraints for climate models constructed to describe the transition between the Last Glacial Maximum and the Holocene, and future changes; but the rate, timing and magnitude of this transition remain uncertain. Here we show that sea level at the shelf edge of the Great Barrier Reef dropped by around 20 metres between 21,900 and 20,500 years ago, to −118 metres relative to the modern level. Our findings are based on recovered and radiometrically dated fossil corals and coralline algae assemblages, and represent relative sea level at the Great Barrier Reef, rather than GMSL. Subsequently, relative sea level rose at a rate of about 3.5 millimetres per year for around 4,000 years. The rise is consistent with the warming previously observed at 19,000 years ago1,5, but we now show that it occurred just after the 20-metre drop in relative sea level and the related increase in global ice volumes. The detailed structure of our record is robust because the Great Barrier Reef is remote from former ice sheets and tectonic activity. Relative sea level can be influenced by Earth’s response to regional changes in ice and water loadings and may differ greatly from GMSL. Consequently, we used glacio-isostatic models to derive GMSL, and find that the Last Glacial Maximum culminated 20,500 years ago in a GMSL low of about −125 to −130 metres.Financial support of this research was provided by the JSPS KAKENHI (grant numbers JP26247085, JP15KK0151, JP16H06309 and JP17H01168), the Australian Research Council (grant number DP1094001), ANZIC, NERC grant NE/H014136/1 and Institut Polytechnique de Bordeaux

Are women graduates jacquelines-of-all-trades? Challenging Lazear’s view on entrepreneurship

This study challenges the basic reasoning behind Lazear’s theory on entrepreneurship (2005). Based on the key motive of maximizing one’s lifetime income, Lazear posits that individuals with a balanced set of skills should have a higher probability of being self-employed. His ‘‘Jack-of-all-trades’’ hypothesis presumes that entrepreneurs need sufficient knowledge in a variety of areas to succeed, while paid employees benefit from being specialists in a certain area demanded by the labor market. Because most women-led businesses are neither based on the motive of making money nor are they growth oriented, we argue that maximizing their lifetime income is not the main motivation of many women to start a business. However, we argue that Lazear’s theory can be extended to motivations that are mostly stated for women entrepreneurs as well. We apply it to a specific representative sample of 1384 women graduates in Germany and test our hypothesis with logit regression. A dichotomized measure indicating whether a women graduate was self-employed (n = 706) or not (n = 678) served as the dependent variable. Our results widely confirm Lazear’s assumption for women graduates who run relatively small businesses in terms of sales and employment: professional training, balanced industry experience, and balanced entrepreneurship-based self-efficacy increase the probability of being self-employed. Solo self-employed tend to have balanced industry experience more often than those being in a team or having employees. Lazear’s theory has male as the norm, and as such, does not readily apply to the case of women—but could and should be extended to women’s specifics

Anatomy of a meltwater drainage system beneath the ancestral East Antarctic ice sheet

Subglacial hydrology is critical to understand the behaviour of ice sheets, yet active meltwater drainage beneath contemporary ice sheets is rarely accessible to direct observation. Using geophysical and sedimentological data from the deglaciated western Ross Sea, we identify a palaeo-subglacial hydrological system active beneath an area formerly covered by the East Antarctic ice sheet. A long channel network repeatedly delivered meltwater to an ice stream grounding line and was a persistent pathway for episodic meltwater drainage events. Embayments within grounding-line landforms coincide with the location of subglacial channels, marking reduced sedimentation and restricted landform growth. Consequently, channelized drainage at the grounding line influenced the degree to which these landforms could provide stability feedbacks to the ice stream. The channel network was connected to upstream subglacial lakes in an area of geologically recent rifting and volcanism, where elevated heat flux would have produced sufficient basal melting to fill the lakes over decades to several centuries; this timescale is consistent with our estimates of the frequency of drainage events at the retreating grounding line. Based on these data, we hypothesize that ice stream dynamics in this region were sensitive to the underlying hydrological system.</p

The paradox of a long grounding during West Antarctic Ice Sheet retreat in Ross Sea

Marine geological data show that the West Antarctic Ice Sheet (WAIS) advanced to the eastern Ross Sea shelf edge during the Last Glacial Maximum (LGM) and eventually retreated ~1000 km to the current grounding-line position on the inner shelf. During the early deglacial, the WAIS deposited a voluminous stack of overlapping grounding zone wedges (GZWs) on the outer shelf of the Whales Deep Basin. The large sediment volume of the GZW cluster suggests that the grounding-line position of the paleo-Bindschadler Ice Stream was relatively stationary for a significant time interval. We used an upper bound estimate of paleo-sediment flux to investigate the lower bound duration over which the ice stream would have deposited sediment to account for the GZW volume. Our calculations show that the cluster represents more than three millennia of ice-stream sedimentation. This long duration grounding was probably facilitated by rapid GZW growth. The subsequent punctuated large-distance (~200 km) grounding-line retreat may have been a highly non-linear ice sheet response to relatively continuous external forcing such as gradual climate warming or sea-level rise. These findings indicate that reliable predictions of future WAIS retreat may require incorporation of realistic calculations of sediment erosion, transport and deposition