Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Performance of missing transverse momentum reconstruction with the ATLAS detector using proton–proton collisions at √s = 13 TeV

The performance of the missing transverse momentum (EmissT) reconstruction with the ATLAS detector is evaluated using data collected in proton–proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct EmissT, fully calibrated electrons, muons, photons, hadronically decaying τ -leptons, and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects. Possible double counting of contributions from reconstructed charged-particle tracks from the inner detector, energy deposits in the calorimeter, and reconstructed muons from the muon spectrometer is avoided by applying a signal ambiguity resolution procedure which rejects already used signals when combining the various EmissT contributions. The individual terms as well as the overall reconstructed EmissT are evaluated with various performance metrics for scale (linearity), resolution, and sensitivity to the data-taking conditions. The method developed to determine the systematic uncertainties of the EmissT scale and resolution is discussed. Results are shown based on the full 2015 data sample corresponding to an integrated luminosity of 3.2 fb−1

Operation and performance of the ATLAS Tile Calorimeter in Run 1

The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events and proton–proton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fb−1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from proton–proton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report

Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector

A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1  fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex

mTOR: from growth signal integration to cancer, diabetes and ageing

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.National Institutes of Health (U.S.)Howard Hughes Medical InstituteWhitehead Institute for Biomedical ResearchJane Coffin Childs Memorial Fund for Medical Research (Postdoctoral Fellowship)Human Frontier Science Program (Strasbourg, France

Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector

A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions

Enhanced neutralizing antibody titers and Th1 polarization from a novel Escherichia coli derived pandemic influenza vaccine

Influenza pandemics can spread quickly and cost millions of lives; the 2009 H1N1 pandemic highlighted the shortfall in the current vaccine strategy and the need for an improved global response in terms of shortening the time required to manufacture the vaccine and increasing production capacity. Here we describe the pre-clinical assessment of a novel 2009 H1N1 pandemic influenza vaccine based on the E. coli-produced HA globular head domain covalently linked to virus-like particles derived from the bacteriophage Qβ. When formulated with alum adjuvant and used to immunize mice, dose finding studies found that a 10 µg dose of this vaccine (3.7 µg globular HA content) induced antibody titers comparable to a 1.5 µg dose (0.7 µg globular HA content) of the licensed 2009 H1N1 pandemic vaccine Panvax, and significantly reduced viral titers in the lung following challenge with 2009 H1N1 pandemic influenza A/California/07/2009 virus. While Panvax failed to induce marked T cell responses, the novel vaccine stimulated substantial antigen-specific interferon-γ production in splenocytes from immunized mice, alongside enhanced IgG2a antibody production. In ferrets the vaccine elicited neutralizing antibodies, and following challenge with influenza A/California/07/2009 virus reduced morbidity and lowered viral titers in nasal lavages

Search for pairs of highly collimated photon-jets in pp collisions at √s = 13 TeV with the ATLAS detector

Results of a search for the pair production of photon-jets—collimated groupings of photons—in the ATLAS detector at the Large Hadron Collider are reported. Highly collimated photon-jets can arise from the decay of new, highly boosted particles that can decay to multiple photons collimated enough to be identified in the electromagnetic calorimeter as a single, photonlike energy cluster. Data from proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 36.7  fb−1, were collected in 2015 and 2016. Candidate photon-jet pair production events are selected from those containing two reconstructed photons using a set of identification criteria much less stringent than that typically used for the selection of photons, with additional criteria applied to provide improved sensitivity to photon-jets. Narrow excesses in the reconstructed diphoton mass spectra are searched for. The observed mass spectra are consistent with the Standard Model background expectation. The results are interpreted in the context of a model containing a new, high-mass scalar particle with narrow width, X, that decays into pairs of photon-jets via new, light particles, a. Upper limits are placed on the cross section times the product of branching ratios σ×B(X→aa)×B(a→γγ)2 for 200  GeV<mX<2  TeV and for ranges of ma from a lower mass of 100 MeV up to between 2 and 10 GeV, depending upon mX. Upper limits are also placed on σ×B(X→aa)×B(a→3π0)2 for the same range of mX and for ranges of ma from a lower mass of 500 MeV up to between 2 and 10 GeV

A Quasar-anchored Protocluster at z = 6.6 in the ASPIRE Survey. II. An Environmental Analysis of Galaxy Properties in an Overdense Structure

\ua9 2025. The Author(s). Published by the American Astronomical Society.We present in this paper (Paper II of the series) a 35 arcmin2 JWST/NIRCam imaging and wide-field slitless spectroscopy mosaic centered on J0305-3150, a luminous quasar at z = 6.61. The F356W grism data reveal 124 [O iii]+Hβ emitters at 5.3 &lt; z &lt; 7, 53 of which constitute a protocluster spanning (10 cMpc)2 across 6.5 &lt; z &lt; 6.8. We find no evidence of any broad-line active galactic nucleus (AGN) in individual galaxies or stacking, reporting a median Hβ FWHM of 585 \ub1 152 km s−1; however, the mass-excitation diagram and “little red dot” color and compactness criteria suggest that there are a few AGN candidates on the outskirts of the protocluster. We fit the spectral energy distributions (SEDs) of the [O iii] emitters with Prospector and Bagpipes and find that none of the SED-derived properties (stellar mass, age, or star formation rate) correlate with proximity to the quasar. While there is no correlation between galaxy age and local galaxy density, we find modest correlations of local galaxy density with increasing stellar mass, decreasing 10-100 Myr star formation rate ratios, and decreasing nebular line equivalent widths. We further find that the protocluster galaxies are consistent with being more massive, being older, and hosting higher star formation rates than the field sample at the 3σ level, distributed in a filamentary structure that supports inside-out formation of the protocluster. There is modest evidence that galaxy evolution proceeds differently as a function of the density of local environment within protoclusters during the epoch of reionization, and the central quasar has little effect on the galaxy properties of the surrounding structure

A Quasar-anchored Protocluster at <em>z</em> = 6.6 in the ASPIRE Survey. I. Properties of [O iii] Emitters in a 10 Mpc Overdensity Structure

\ua9 2025. The Author(s). Published by the American Astronomical Society.A SPectroscopic survey of bIased halos in the Reionization Era is a quasar legacy survey primarily using JWST to target a sample of 25 z &gt; 6 quasars with NIRCam slitless spectroscopy and imaging. The first study in this series found evidence of a strong overdensity of galaxies around J0305−3150, a luminous quasar at z = 6.61, within a single NIRCam pointing obtained in JWST Cycle 1. Here we present the first results of a JWST Cycle 2 mosaic that covers 35 arcmin2 with NIRCam imaging/wide-field slitless spectroscopy of the same field to investigate the spatial extent of the putative protocluster. The F356W grism data target [O iii]+Hβ at 5.3 &lt; z &lt; 7 and reveal a population of 124 line emitters down to a flux limit of 1.2 7 10−18 erg s−1 cm−2. Fifty-three of these galaxies lie at 6.5 &lt; z &lt; 6.8 spanning 10 cMpc on the sky, corresponding to an overdensity within a 2500 cMpc3 volume of 12.5 \ub1 2.6, anchored by the quasar. Comparing to the [O iii] luminosity function from the Emission line galaxies and Intergalactic Gas in the Epoch of Reionization project, we find a dearth of faint [O iii] emitters at log(L/erg s−1) &lt; 42.3, which we suggest is consistent with either bursty star formation causing galaxies to scatter around the grism detection limit or modest suppression from quasar feedback. While we find a strong filamentary overdensity of [O iii] emitters consistent with a protocluster, we suggest that we could be insensitive to a population of older, more massive Lyman break galaxies with weak nebular emission on scales &gt;​​​​​​10 cMpc