Effect of watershed partitioning on hydrologic parameters and estimation of hydrograph of an ungauged basin: a case study in Gokirmak and Kocanaz, Turkey

The main goal of this study is to investigate the effect of the size of the subbasins of a watershed on the hydrologic parameters and their spatial variability in an estimation of the hydrologic parameters and hydrograph of a neighbouring ungauged basin. In this paper, Hydrologic Engineering Center-Hydrologic Modelling System (HEC-HMS), a semi-distributed hydrologic model, is used to calibrate and cross-validate two flood events occurred in 1998 and then validate four other flood events occurred in 1991, 1994, 2002, and 2009 in Gokirmak Basin in Western Black Sea Region, Turkey. The basin is divided into seven different subbasins to investigate the effect of watershed partitioning on calibrated hydrologic parameters of each subbasin using the peak-weighted root mean square error method as an objective function and the hydrograph at the outlet of the whole basin. It is found out that as the geometric magnitudes of the subbasins changed, the calibrated values of the hydrologic parameters of those subbasins changed as well. Then, a neighbouring basin, Kocanaz, is considered as an assumed neighbouring ungauged basin to investigate the effect of watershed partitioning of a gauged basin on the estimation of hydrograph of a neighbouring ungauged basin. Hydrologic parameters and direct runoff hydrograph of assumed ungauged neighbouring basin are estimated from the hydrologic parameters of the HEC-HMS calibration results of Gokirmak. Statistical indicators of the simulation results for each basin partitioning were graded with respect to the boundary values of the simulation outputs to find the best alternative. The grading results show that the simulation results with a single basin gave better representation among all other partitioning except two flood events

Microtubule Organization and Microtubule-Associated Proteins (MAPs)

Dendrites have a unique microtubule organization. In vertebrates, dendritic microtubules are organized in antiparallel bundles, oriented with their plus ends either pointing away or toward the soma. The mixed microtubule arrays control intracellular trafficking and local signaling pathways, and are essential for dendrite development and function. The organization of microtubule arrays largely depends on the combined function of different microtubule regulatory factors or generally named microtubule-associated proteins (MAPs). Classical MAPs, also called structural MAPs, were identified more than 20 years ago based on their ability to bind to and copurify with microtubules. Most classical MAPs bind along the microtubule lattice and regulate microtubule polymerization, bundling, and stabilization. Recent evidences suggest that classical MAPs also guide motor protein transport, interact with the actin cytoskeleton, and act in various neuronal signaling networks. Here, we give an overview of microtubule organization in dendrites and the role of classical MAPs in dendrite development, dendritic spine formation, and synaptic plasticity