Extragalactic Radio Continuum Surveys and the Transformation of Radio Astronomy

Next-generation radio surveys are about to transform radio astronomy by discovering and studying tens of millions of previously unknown radio sources. These surveys will provide new insights to understand the evolution of galaxies, measuring the evolution of the cosmic star formation rate, and rivalling traditional techniques in the measurement of fundamental cosmological parameters. By observing a new volume of observational parameter space, they are also likely to discover unexpected new phenomena. This review traces the evolution of extragalactic radio continuum surveys from the earliest days of radio astronomy to the present, and identifies the challenges that must be overcome to achieve this transformational change.Comment: To be published in Nature Astronomy 18 Sept 201

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Peroxisome Proliferator-Activated Receptor-Gamma Agonists Suppress Tissue Factor Overexpression in Rat Balloon Injury Model with Paclitaxel Infusion

The role and underlying mechanisms of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, on myocardial infarction are poorly understood. We investigated the effects of this PPAR-γ agonist on the expression of tissue factor (TF), a primary molecule for thrombosis, and elucidated its underlying mechanisms. The PPAR-γ agonist inhibited TF expression in response to TNF-α in human umbilical vein endothelial cells, human monocytic leukemia cell line, and human umbilical arterial smooth muscle cells. The overexpression of TF was mediated by increased phosphorylation of mitogen-activated protein kinase (MAPK), which was blocked by the PPAR-γ agonist. The effective MAPK differed depending on each cell type. Luciferase and ChIP assays showed that transcription factor, activator protein-1 (AP-1), was a pivotal target of the PPAR-γ agonist to lower TF transcription. Intriguingly, two main drugs for drug-eluting stent, paclitaxel or rapamycin, significantly exaggerated thrombin-induced TF expression, which was also effectively blocked by the PPAR-γ agonist in all cell types. This PPAR-γ agonist did not impair TF pathway inhibitor (TFPI) in three cell types. In rat balloon injury model (Sprague-Dawley rats, n = 10/group) with continuous paclitaxel infusion, the PPAR-γ agonist attenuated TF expression by 70±5% (n = 4; P<0.0001) in injured vasculature. Taken together, rosiglitazone reduced TF expression in three critical cell types involved in vascular thrombus formation via MAPK and AP-1 inhibitions. Also, this PPAR-γ agonist reversed the paclitaxel-induced aggravation of TF expression, which suggests a possibility that the benefits might outweigh its risks in a group of patients with paclitaxel-eluting stent implanted

<em>Euclid</em>: Early Release Observations – The intracluster light and intracluster globular clusters of the Perseus cluster

\ua9 The Authors 2025. We study the intracluster light (ICL) and intracluster globular clusters (ICGCs) in the nearby Perseus cluster of galaxies using Euclid’s Early Release Observations. By modelling the isophotal and iso-density contours, we mapped the distributions and properties of the ICL and ICGCs out to radii of 200–600 kpc (up to ∼ 13 of the virial radius, depending on the parameter) from the brightest cluster galaxy (BCG). We find that the central 500 kpc of the Perseus cluster hosts 70 000 \ub1 2800 globular clusters, and 1.7 7 1012 L☉ of diffuse light from the BCG+ICL in the near-infrared HE. This accounts for 38 \ub1 6% of the cluster’s total stellar luminosity within this radius. The ICL and ICGCs share a coherent spatial distribution which suggests that they have a common origin or that a common potential governs their distribution. Their contours on the largest scales (&gt;200 kpc) are not centred on the BCG’s core, but are instead offset westwards by 60 kpc towards several luminous cluster galaxies. This offset is opposite to the displacement observed in the gaseous intracluster medium. The radial surface brightness profile of the BCG+ICL is best described by a double S\ue9rsic model, with 68 \ub1 4% of the HE light contained in the extended, outer component. The transition between these components occurs at ≈60 kpc, beyond which the isophotes become increasingly elliptical and off-centred. Furthermore, the radial ICGC number density profile closely follows the profile of the BCG+ICL only beyond this 60 kpc radius, where we find an average of 60–80 globular clusters per 109 M☉ of diffuse stellar mass. The BCG+ICL colour becomes increasingly blue with radius, consistent with the stellar populations in the ICL having subsolar metallicities [Fe/H] ∼−0.6 to −1.0. The colour of the ICL, and the specific frequency and luminosity function of the ICGCs suggest that the ICL+ICGCs were tidally stripped from the outskirts of massive satellites with masses of a few 71010 M☉, with an increasing contribution from dwarf galaxies at large radii