'The Fittest on Earth': Performance and Image Enhancing Drugs Use Within UK CrossFit Communities

While there are different harms that are related to sport/exercise (hooliganism, gambling, drug use, violence, etc.), in this chapter we are particularly interested in exploring the ‘subjective harms’ and ‘embedded harms’ associated with the exercise regime known as CrossFit, with specific attention to the use of performance and image enhancing drugs (PIEDs) and dietary supplements within this milieu. Drawing on the deviant leisure perspective, the chapter explores the possible ways in which CrossFitters may ‘self-harm’ in their conformity to social norms and values and specifically the cultural injunction to either perform or be aesthetically appealing and, more importantly, how these harms may be mitigated, meditated or exacerbated by a CrossFit leisure identity. The main purpose of this chapter is to (1) empirically investigate the reported prevalence of supplements and PIEDs in CrossFit within the UK, (2) examine the relationship between CrossFit and (un)healthy behaviours and practices more generally and (3) situate our findings within the broader theoretical lens of deviant leisure

Amphetamine sensitization and cross-sensitization with acute restraint stress: impact of prenatal alcohol exposure in male and female rats

RATIONALE: Individuals with fetal alcohol spectrum disorder (FASD) are at increased risk for substance use disorders (SUD). In typically developing individuals, susceptibility to SUD is associated with alterations in dopamine and hypothalamic-pituitary-adrenal (HPA) systems, and their interactions. Prenatal alcohol exposure (PAE) alters dopamine and HPA systems, yet effects of PAE on dopamine-HPA interactions are unknown. Amphetamine-stress cross-sensitization paradigms were utilized to investigate sensitivity of dopamine and stress (HPA) systems, and their interactions following PAE. METHODS: Adult Sprague-Dawley offspring from PAE, pair-fed, and ad libitum-fed control groups were assigned to amphetamine-(1–2mg/kg) or saline-treated conditions, with injections every other day for 15 days. 14 days later, all animals received an amphetamine challenge (1mg/kg) and 5 days later, hormones were measured under basal or acute stress conditions. Amphetamine sensitization (augmented locomotion, days 1–29) and cross-sensitization with acute restraint stress (increased stress hormones, day 34) were assessed. RESULTS: PAE rats exhibited a lower threshold for amphetamine sensitization compared to controls, suggesting enhanced sensitivity of dopaminergic systems to stimulant-induced changes. Cross-sensitization between amphetamine (dopamine) and stress (HPA hormone) systems was evident in PAE, but not in control rats. PAE males exhibited increased dopamine receptor expression (mPFC) compared to controls. CONCLUSIONS: PAE alters induction and expression of sensitization/cross-sensitization, as reflected in locomotor, neural, and endocrine changes, in a manner consistent with increased sensitivity of dopamine and stress systems. These results provide insight into possible mechanisms that could underlie increased prevalence of SUD, as well as the impact of widely prescribed stimulant medications among adolescents with FASD