Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

The central nervous system (CNS) is capable of gathering information on the body’s nutritional state and it implements appropriate behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus, to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the development of obesity and type 2 diabetes mellitus

Rare giant cystic lesion

Resumen Presentamos este caso clínico, en el que de forma incidental se diagnostica una lesión multiquística gigante, que finalmente resultó ser un mesotelioma quístico benigno. Se discuten algunos aspectos relevantes en el manejo de esta entidad, que aunque de comportamiento benigno, presenta una elevada tasa de recidiva tras su resección.</p

A Meta-analysis of the International Experience–Ownership Strategy Relationship: A Dynamic Capabilities View

This paper investigates the context in which firms’ ownership strategies in international ventures may be affected by their international experience, which shapes their dynamic capabilities. Based on a statistical synthesis of empirical insights accumulated in a large body of literature, this paper examines multiple firm-, industry-, and country-specific moderators simultaneously. With models tested drawing on data from 102 samples across 114,118 international entry decisions, this meta-analysis finds empirical evidence largely supporting theoretical predictions of sources of international experience, economic development stages of host countries and firm size that moderate the relationship between international experience and ownership strategy (IE–OS relationship), and this relationship is not contingent upon industries in which a firm resides. In particular, the contingency effect of country-specific experience is more important to the IE–OS relationship than others. This paper demonstrates the contextual nature of the IE–OS relationship and contributes insights into the contingencies that affect the impact of experience-based dynamic capability deployment in an international business setting