Optical Phase-Space-Time-Frequency Tomography

We present a new approach for constructing optical phase-space-time-frequency tomography (OPSTFT) of an optical wave field. This tomography can be measured by using a novel four-window optical imaging system based on two local oscillator fields balanced heterodyne detection. The OPSTFT is a Wigner distribution function of two independent Fourier Transform pairs, i.e., phase-space and time-frequency. From its theoretical and experimental aspects, it can provide information of position, momentum, time and frequency of a spatial light field with precision beyond the uncertainty principle. We simulate the OPSTFT for a light field obscured by a wire and a single-line absorption filter. We believe that the four-window system can provide spatial and temporal properties of a wave field for quantum image processing and biophotonics.Comment: 11 pages, 6 figure

Stellar Parameters for HD 69830, a Nearby Star with Three Neptune Mass Planets and an Asteroid Belt

We used the CHARA Array to directly measure the angular diameter of HD 69830, home to three Neptune mass planets and an asteroid belt. Our measurement of 0.674+/-0.014 milli-arcseconds for the limb-darkened angular diameter of this star leads to a physical radius of R$_*$ = 0.9058$\pm$0.0190 R\sun and luminosity of L* = 0.622+/-0.014 Lsun when combined with a fit to the spectral energy distribution of the star. Placing these observed values on an Hertzsprung-Russel (HR) diagram along with stellar evolution isochrones produces an age of 10.6+/-4 Gyr and mass of 0.863$\pm$0.043 M\sun. We use archival optical echelle spectra of HD 69830 along with an iterative spectral fitting technique to measure the iron abundance ([Fe/H]=-0.04+/-0.03), effective temperature (5385+/-44 K) and surface gravity (log g = 4.49+/-0.06). We use these new values for the temperature and luminosity to calculate a more precise age of 7.5+/-Gyr. Applying the values of stellar luminosity and radius to recent models on the optimistic location of the habitable zone produces a range of 0.61-1.44 AU; partially outside the orbit of the furthest known planet (d) around HD 69830. Finally, we estimate the snow line at a distance of 1.95+/-0.19 AU, which is outside the orbit of all three planets and its asteroid belt.Comment: 5 pages, 3 figures, accepted to Ap

Current status of intestinal transplantation in children

Purpose: A clinical trial of intestinal transplantation (Itx) under tacrolimus and prednisone immunosuppression was initiated in June 1990 in children with irreversible intestinal failure and who were dependent on total parenteral nutrition (TPN). Methods: Fifty-five patients (28 girls, 27 boys) with a median age of 3.2 years (range, 0.5 to 18 years) received 58 intestinal transplants that included isolated small bowel (SB) (n = 17), liver SB (LSB) (n = 33), and multivisceral (MV) (n = 8) allografts. Nine patients also received bone marrow infusion, and there were 20 colonic allografts. Azathioprine, cyclophosphamide, or mycophenolate mofetil were used in different phases of the series. Indications for Itx included: gastroschisis (n = 14), volvulus (n = 13), necrotizing enterocolitis (n = 6), intestinal atresia (n = 8), chronic intestinal pseudoobstruction (n = 5), Hirschsprung's disease (n = 4), microvillus inclusion disease (n = 3), multiple polyposis (n = 1), and trauma (n = 1). Results: Currently, 30 patients are alive (patient survival, 55%; graft survival, 52%). Twenty-nine children with functioning grafts are living at home and off TPN, with a mean follow-up of 962 (range, 75 to 2,424) days. Immunologic complications have included liver allograft rejection (n = 18), intestinal allograft rejection (n = 52), posttransplant lymphoproliferative disease (n = 16), cytomegalovirus (n = 16) and graft-versus-host disease (n = 4). A combination of associated complications included intestinal perforation (n = 4), biliary leak (n = 3), bile duct stenosis (n = 1), intestinal leak (n = 6), dehiscence with evisceration (n = 4), hepatic artery thrombosis (n = 3), bleeding (n = 9), portal vein stenosis (n = 1), intraabdominal abscess (n = 11), and chylous ascites (n = 4). Graft loss occurred as a result of rejection (n = 8), infection (n = 12), technical complications (n = 8), and complications of TPN after graft removal (n = 3). There were four retransplants (SB, n = 1; LSB n = 3). Conclusions: Intestinal transplantation is a valid therapeutic option for patients with intestinal failure suffering complications of TPN. The complex clinical and immunologic course of these patients is reflected in a higher complication rate as well as patient and graft loss than seen after heart, liver, and kidney transplantation, although better than after lung transplantation

Interferometry of ϵ\epsilon Aurigae: Characterization of the asymmetric eclipsing disk

We report on a total of 106 nights of optical interferometric observations of the $\epsilon$ Aurigae system taken during the last 14 years by four beam combiners at three different interferometric facilities. This long sequence of data provides an ideal assessment of the system prior to, during, and after the recent 2009-2011 eclipse. We have reconstructed model-independent images from the 10 in-eclipse epochs which show that a disk-like object is indeed responsible for the eclipse. Using new 3D, time-dependent modeling software, we derive the properties of the F-star (diameter, limb darkening), determine previously unknown orbital elements ($\Omega$, $i$), and access the global structures of the optically thick portion of the eclipsing disk using both geometric models and approximations of astrophysically relevant density distributions. These models may be useful in future hydrodynamical modeling of the system. Lastly, we address several outstanding research questions including mid-eclipse brightening, possible shrinking of the F-type primary, and any warps or sub-features within the disk.Comment: 105 pages, 57 figures. This is an author-created, un-copyedited version of an article accepted for publication in Astrophysical Journal Supplement Series. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i

Colder and Hotter: Interferometric Imaging of _ Cassiopeiae and _ Leonis

Near-infrared interferometers have recently imaged a number of rapidly rotating A-type stars, finding levels of gravity darkening inconsistent with theoretical expectations. Here, we present new imaging of both a cooler star _ Cas (F2IV) and a hotter one _ Leo (B7V) using the CHARA array and the MIRC instrument at the H band. Adopting a solid-body rotation model with a simple gravity darkening prescription, we modeled the stellar geometric properties and surface temperature distributions, confirming that both stars are rapidly rotating and show gravity darkening anomalies. We estimate the masses and ages of these rapid rotators on L - R pol and H-R diagrams constructed for non-rotating stars by tracking their non-rotating equivalents. The unexpected fast rotation of the evolved sub-giant _ Cas offers a unique test of the stellar core-envelope coupling, revealing quite efficient coupling over the past ~0.5 Gyr. Lastly, we summarize all our interferometric determinations of the gravity darkening coefficient for rapid rotators, finding that none match the expectations from the widely used von Zeipel gravity darkening laws. Since the conditions of the von Zeipel law are known to be violated for rapidly rotating stars, we recommend using the empirically derived _ = 0.19 for such stars with radiation-dominated envelopes. Furthermore, we note that no paradigm exists for self-consistently modeling heavily gravity-darkened stars that show hot radiative poles with cool convective equators.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90751/1/0004-637X_732_2_68.pd

Digging by Debating: Linking massive datasets to specific arguments

We will develop and implement a multi-scale workbench, called "InterDebates", with the goal of digging into data provided by hundreds of thousands, eventually millions, of digitized books, bibliographic databases of journal articles, and comprehensive reference works written by experts. Our hypotheses are: that detailed and identifiable arguments drive many aspects of research in the sciences and the humanities; that argumentative structures can be extracted from large datasets using a mixture of automated and social computing techniques; and, that the availability of such analyses will enable innovative interdisciplinary research, and may also play a role in supporting better-informed critical debates among students and the general public. A key challenge tackled by this project is thus to uncover and represent the argumentative structure of digitized documents, allowing users to find and interpret detailed arguments in the broad semantic landscape of books and articles

In the Shadow of the Transiting Disk: Imaging epsilon Aurigae in Eclipse

Eclipses of the single-line spectroscopic binary star, epsilon Aurigae, provide an opportunity to study the poorly-defined companion. We used the MIRC beam combiner on the CHARA array to create interferometric images during eclipse ingress. Our results demonstrate that the eclipsing body is a dark disk that is opaque and tilted, and therefore exclude alternative models for the system. These data constrain the geometry and masses of the components, providing evidence that the F-star is not a massive supergiant star.Comment: As submitted to Nature. Published in Nature April 8, 2010

Insights into the Structured Coordination Game with Neutral Options through Simulation

Coordination games have been of interest to game theorists, economists, and ecologists for many years to study such problems as the emergence of local conventions and the evolution of cooperative behavior. Approaches for understanding the coordination game with discrete structure have been limited in scope, often relying on symmetric reduction of the state space, or other constraints which limit the power of the model to give insight into desired applications. In this paper, we introduce a new way of thinking about equilibria of the structured coordination game with neutral strategies by means of graph partitioning. We begin with a few elementary game theoretical results and then catalogue all the Nash equilibria of the coordination game with neutral options for graphs with seven or fewer vertices. We extend our observations through the use of simulation on larger Erd\H{o}s-R\'enyi random graphs to form the basis for proposing some conjectures about the general relationships among edge density, cluster number, and consensus stability

Imaging the surface of Altair and a MIRC update

We report the first scientific results from the Michigan Infrared Combiner (MIRC), including the first resolved image of a main-sequence star besides the Sun. Using the CHARA Array, MIRC was able to clearly resolve the well-known elongation of Altair's photosphere due to centrifugal distortion, and was also able to unambiguously image the effect of gravity darkening. In this report, we also show preliminary images of the interacting binary β Lyr and give an update of MIRC performance

Implantable cardioverter defibrillators for the treatment of arrhythmias and cardiac resynchronisation therapy for the treatment of heart failure: systematic review and economic evaluation

Background This assessment updates and expands on two previous technology assessments that evaluated implantable cardioverter defibrillators (ICDs) for arrhythmias and cardiac resynchronisation therapy (CRT) for heart failure (HF). Objectives To assess the clinical effectiveness and cost-effectiveness of ICDs in addition to optimal pharmacological therapy (OPT) for people at increased risk of sudden cardiac death (SCD) as a result of ventricular arrhythmias despite receiving OPT; to assess CRT with or without a defibrillator (CRT-D or CRT-P) in addition to OPT for people with HF as a result of left ventricular systolic dysfunction (LVSD) and cardiac dyssynchrony despite receiving OPT; and to assess CRT-D in addition to OPT for people with both conditions. Data sources Electronic resources including MEDLINE, EMBASE and The Cochrane Library were searched from inception to November 2012. Additional studies were sought from reference lists, clinical experts and manufacturers’ submissions to the National Institute for Health and Care Excellence. Review methods Inclusion criteria were applied by two reviewers independently. Data extraction and quality assessment were undertaken by one reviewer and checked by a second. Data were synthesised through narrative review and meta-analyses. For the three populations above, randomised controlled trials (RCTs) comparing (1) ICD with standard therapy, (2) CRT-P or CRT-D with each other or with OPT and (3) CRT-D with OPT, CRT-P or ICD were eligible. Outcomes included mortality, adverse events and quality of life. A previously developed Markov model was adapted to estimate the cost-effectiveness of OPT, ICDs, CRT-P and CRT-D in the three populations by simulating disease progression calculated at 4-weekly cycles over a lifetime horizon. Results A total of 4556 references were identified, of which 26 RCTs were included in the review: 13 compared ICD with medical therapy, four compared CRT-P/CRT-D with OPT and nine compared CRT-D with ICD. ICDs reduced all-cause mortality in people at increased risk of SCD, defined in trials as those with previous ventricular arrhythmias/cardiac arrest, myocardial infarction (MI) > 3 weeks previously, non-ischaemic cardiomyopathy (depending on data included) or ischaemic/non-ischaemic HF and left ventricular ejection fraction ≤ 35%. There was no benefit in people scheduled for coronary artery bypass graft. A reduction in SCD but not all-cause mortality was found in people with recent MI. Incremental cost-effectiveness ratios (ICERs) ranged from £14,231 per quality-adjusted life-year (QALY) to £29,756 per QALY for the scenarios modelled. CRT-P and CRT-D reduced mortality and HF hospitalisations, and improved other outcomes, in people with HF as a result of LVSD and cardiac dyssynchrony when compared with OPT. The rate of SCD was lower with CRT-D than with CRT-P but other outcomes were similar. CRT-P and CRT-D compared with OPT produced ICERs of £27,584 per QALY and £27,899 per QALY respectively. The ICER for CRT-D compared with CRT-P was £28,420 per QALY. In people with both conditions, CRT-D reduced the risk of all-cause mortality and HF hospitalisation, and improved other outcomes, compared with ICDs. Complications were more common with CRT-D. Initial management with OPT alone was most cost-effective (ICER £2824 per QALY compared with ICD) when health-related quality of life was kept constant over time. Costs and QALYs for CRT-D and CRT-P were similar. The ICER for CRT-D compared with ICD was £27,195 per QALY and that for CRT-D compared with OPT was £35,193 per QALY. Limitations Limitations of the model include the structural assumptions made about disease progression and treatment provision, the extrapolation of trial survival estimates over time and the assumptions made around parameter values when evidence was not available for specific patient groups. Conclusions In people at risk of SCD as a result of ventricular arrhythmias and in those with HF as a result of LVSD and cardiac dyssynchrony, the interventions modelled produced ICERs of < £30,000 per QALY gained. In people with both conditions, the ICER for CRT-D compared with ICD, but not CRT-D compared with OPT, was < £30,000 per QALY, and the costs and QALYs for CRT-D and CRT-P were similar. A RCT comparing CRT-D and CRT-P in people with HF as a result of LVSD and cardiac dyssynchrony is required, for both those with and those without an ICD indication. A RCT is also needed into the benefits of ICD in non-ischaemic cardiomyopathy in the absence of dyssynchrony. Study registration This study is registered as PROSPERO number CRD42012002062. Funding The National Institute for Health Research Health Technology Assessment programme