Seeking out and building monopolies, Rothschild strategies in non ferrous metals international markets (1830-1940)

The aim of this article is to analyse the strategies employed by the Rothschilds until 1940 to limit competition in the non ferrous international market. We will study how they opted for rigid demand products of highly concentrated supply which were favourable to market control (mercury, nickel, lead and copper and sulphur) by assuming administrative monopolies (mercury from Spanish Almadn Mines) or through control of the leading businesses of the respective markets (Le Nickel, Pearroya and Rio Tinto). We will also analyse how the family was able to gain worldwide monopolies, or if not, how they promoted collusive oligopolies with the competition in any number of forms in their quest to maintain profitability and to flee from any competition.International Raw material markets, Cartels, Rothschild, mining, Non-ferrous metals.

Partial separability and entanglement criteria for multiqubit quantum states

We explore the subtle relationships between partial separability and entanglement of subsystems in multiqubit quantum states and give experimentally accessible conditions that distinguish between various classes and levels of partial separability in a hierarchical order. These conditions take the form of bounds on the correlations of locally orthogonal observables. Violations of such inequalities give strong sufficient criteria for various forms of partial inseparability and multiqubit entanglement. The strength of these criteria is illustrated by showing that they are stronger than several other well-known entanglement criteria (the fidelity criterion, violation of Mermin-type separability inequalities, the Laskowski-\.Zukowski criterion and the D\"ur-Cirac criterion), and also by showing their great noise robustness for a variety of multiqubit states, including N-qubit GHZ states and Dicke states. Furthermore, for N greater than or equal to 3 they can detect bound entangled states. For all these states, the required number of measurement settings for implementation of the entanglement criteria is shown to be only N+1. If one chooses the familiar Pauli matrices as single-qubit observables, the inequalities take the form of bounds on the anti-diagonal matrix elements of a state in terms of its diagonal matrix elements.Comment: 25 pages, 3 figures. v4: published versio

3D Neuro-electronic interface devices for neuromuscular control: Design studies and realisation steps

In order to design the shape and dimensions of new 3D multi-microelectrode information transducers properly, i. e. adapted to the scale of information delivery to and from peripheral nerve fibres, a number of studies were, and still are, being performed on modelling and simulation of electrical volume conduction inside and outside nerves, on animal experiments on stimulation and recording with single wires and linear arrays, and on new technologies for 3D micro-fabrication. This paper presents a selection of the results of these `Neurotechnology¿ studies at the University of Twente. The experimental and simulation results apply primarily to the peripheral motor nerves of the rat, but are also of interest for neural interfacing with myelinated nerves in man, as fascicles in man are about the same size as in the rat

Multilevel analysis of nuclear dynamics in lamin perturbed fibroblasts

The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies. On the cellular level, lamin mutations affect the physical integrity of nuclei and nucleo-cytoskeletal interactions, resulting in increased susceptibility to mechanical stress and altered gene expression [1]. Most studies regarding the mechanical properties of the nucleus in laminopathic conditions are based on the induction of extracellular stress, such as strain or compression, and focus on nuclear integrity and/or nucleo-cytoskeletal interaction [2]. Far less is known about the role of nuclear organization and mobility under basal steady-state conditions. In this study, we quantitatively compared nuclear organization, nuclear deformation and chromatin mobility of fibroblasts from a Hutchinson-Gilford progeria patient with cells from a lamin A/C-deficient patient and wild-type dermal fibroblasts. To this end, we created a toolbox in imageJ for automatically analyzing both nuclear as well as subnuclear dynamics in living cells. Simultaneously, we developed a workflow for comparing cellular morphology and subcellular protein distribution in a high content fashion. We found that the absence of functional lamin A/C leads to increased nuclear plasticity on the hour and minute time scale but also to increased intranuclear mobility down to the seconds time scale. In contrast, progeria cells showed overall reduced nuclear dynamics. In addition, high content analysis revealed marked morphological and topological differences between different culture passages within a cell type and between different pathological variants of culture-age matched laminopathic cell types