2,480 research outputs found
Direct Observation of Condon Domains in Silver by Hall Probes
Using a set of micro Hall probes for the detection of the local induction,
the inhomogeneous Condon domain structure has been directly observed at the
surface of a pure silver single crystal under strong Landau quantization in
magnetic fields up to 10 T. The inhomogeneous induction occurs in the
theoretically predicted part of the H-T Condon domain phase diagram.
Information about size, shape and orientation of the domains is obtained by
analyzing Hall probes placed along and across the long sample axis and by
tilting the sample. On a beryllium surface the induction inhomogeneity is
almost absent although the expected induction splitting here is at least ten
times higher than in silver.Comment: 4 pages, 6 figures, submitted to PR
Multilevel analysis of nuclear dynamics in lamin perturbed fibroblasts
The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies. On the cellular level, lamin mutations affect the physical integrity of nuclei and nucleo-cytoskeletal interactions, resulting in increased susceptibility to mechanical stress and altered gene expression [1]. Most studies regarding the mechanical properties of the nucleus in laminopathic conditions are based on the induction of extracellular stress, such as strain or compression, and focus on nuclear integrity and/or nucleo-cytoskeletal interaction [2]. Far less is known about the role of nuclear organization and mobility under basal steady-state conditions.
In this study, we quantitatively compared nuclear organization, nuclear deformation and chromatin mobility of fibroblasts from a Hutchinson-Gilford progeria patient with cells from a lamin A/C-deficient patient and wild-type dermal fibroblasts. To this end, we created a toolbox in imageJ for automatically analyzing both nuclear as well as subnuclear dynamics in living cells. Simultaneously, we developed a workflow for comparing cellular morphology and subcellular protein distribution in a high content fashion.
We found that the absence of functional lamin A/C leads to increased nuclear plasticity on the hour and minute time scale but also to increased intranuclear mobility down to the seconds time scale. In contrast, progeria cells showed overall reduced nuclear dynamics. In addition, high content analysis revealed marked morphological and topological differences between different culture passages within a cell type and between different pathological variants of culture-age matched laminopathic cell types
DAzLE: The Dark Ages z (redshift) Lyman-alpha Explorer
DAzLE is an near infrared narrowband differential imager being built by the
Institute of Astronomy, Cambridge, in collaboration with the Anglo-Australian
observatory. It is a special purpose instrument designed with a sole aim; the
detection of redshifted Lyman-alpha emission from star forming galaxies at z>7.
DAzLE will use pairs of high resolution (R=1000) narrowband filters to exploit
low background `windows' in the near infrared sky emission spectrum. This will
enable it to reach sensitivities of ~2E-21 W/m^2, thereby allowing the
detection of z>7 galaxies with star formation rates as low as a few solar
masses per year. The design of the instrument, and in particular the crucial
narrowband filters, are presented. The predicted performance of DAzLE,
including the sensitivity, volume coverage and expected number counts, is
discussed. The current status of the DAzLE project, and its projected timeline,
are also presented.Comment: 11 pages, 7 figures, to appear in Proceedings of SPIE Vol. 5492,
Ground-based Instrumentation for Astronom
Hysteresis in the de Haas-van Alphen Effect
A hysteresis loop is observed for the first time in the de Haas-van Alphen
(dHvA) effect of beryllium at low temperatures and quantizing magnetic field
applied parallel to the hexagonal axis of the single crystal. The irreversible
behavior of the magnetization occurs at the paramagnetic part of the dHvA
period in conditions of Condon domain formation arising by strong enough dHvA
amplitude. The resulting extremely nonlinear response to a very small
modulation field offers the possibility to find in a simple way the Condon
domain phase diagram. From a harmonic analysis, the shape and size of the
hysteresis loop is constructed.Comment: 4 pages, 5 figures, submitted to PR
Product Service System Innovation in the Smart City
Product service systems (PSS) may usefully form part of the mix of innovations necessary to move society toward more sustainable futures. However, despite such potential, PSS implementation is highly uneven and limited. Drawing on an alternate socio-technical perspective of innovation, this paper provides fresh insights, on among other things the role of context in PSS innovation, to address this issue. Case study research is presented focusing on a use orientated PSS in an urban environment: the Copenhagen city bike scheme. The paper shows that PSS innovation is a situated complex process, shaped by actors and knowledge from other locales. It argues that further research is needed to investigate how actors interests shape PSS innovation. It recommends that institutional spaces should be provided in governance landscapes associated with urban environments to enable legitimate PSS concepts to co-evolve in light of locally articulated sustainability principles and priorities
General Anti-Avoidance Rules (GAARs) : A Key Element of Tax Systems in the Post-BEPS Tax World? : Spanish Report
Smart Cities: Towards a New Citizenship Regime? A Discourse Analysis of the British Smart City Standard
Growing practice interest in smart cities has led to calls for a less technology-oriented and more citizen-centric approach. In response, this articles investigates the citizenship mode promulgated by the smart city standard of the British Standards Institution. The analysis uses the concept of citizenship regime and a mixture of quantitative and qualitative methods to discern key discursive frames defining the smart city and the particular citizenship dimensions brought into play. The results confirm an explicit citizenship rationale guiding the smart city (standard), although this displays some substantive shortcomings and contradictions. The article concludes with recommendations for both further theory and practice development
M-Dwarf Fast Rotators and the Detection of Relatively Young Multiple M-Star Systems
We have searched the Kepler light curves of ~3900 M-star targets for evidence
of periodicities that indicate, by means of the effects of starspots, rapid
stellar rotation. Several analysis techniques, including Fourier transforms,
inspection of folded light curves, 'sonograms', and phase tracking of
individual modulation cycles, were applied in order to distinguish the
periodicities due to rapid rotation from those due to stellar pulsations,
eclipsing binaries, or transiting planets. We find 178 Kepler M-star targets
with rotation periods, P_rot, of < 2 days, and 110 with P_rot < 1 day. Some 30
of the 178 systems exhibit two or more independent short periods within the
same Kepler photometric aperture, while several have three or more short
periods. Adaptive optics imaging and modeling of the Kepler pixel response
function for a subset of our sample support the conclusion that the targets
with multiple periods are highly likely to be relatively young physical binary,
triple, and even quadruple M star systems. We explore in detail the one object
with four incommensurate periods all less than 1.2 days, and show that two of
the periods arise from one of a close pair of stars, while the other two arise
from the second star, which itself is probably a visual binary. If most of
these M-star systems with multiple periods turn out to be bound M stars, this
could prove a valuable way of discovering young hierarchical M-star systems;
the same approach may also be applicable to G and K stars. The ~5% occurrence
rate of rapid rotation among the ~3900 M star targets is consistent with spin
evolution models that include an initial contraction phase followed by magnetic
braking, wherein a typical M star can spend several hundred Myr before spinning
down to periods longer than 2 days.Comment: 17 pages, 12 figures, 2 tables; accepted for publication in The
Astrophysical Journa
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