19,706 research outputs found
EQUILIBRIUM AGENDA FORMATION
We develop a definition of equilibrium for agenda formation in general voting settings. The definition is independent of any protocol. We show that the set of equilibrium outcomes for any Pareto efficient voting rule is uniquely determined. We also show that for such voting rules, if preferences are strict then the set of equilibrium outcomes coincides with that of the outcomes generated by considering all full agendas for voting by successive elimination and show that the set of equilibrium outcomes corresponds with the Banks set. We also examine the implications in several other settings.Agenda ; Equilibrium ; Voting
Equilibrium Agenda Formation
We develop a definition of equilibrium for agenda formation in general voting settings. The definition is independent of any protocol. We show that the set of equilibrium outcomes for any Pareto efficient voting rule is uniquely determined, and in fact coincides with that of the outcomes generated by considering all full agendas. Under voting by successive elimination (or amendment), the set of equilibrium outcomes corresponds with the Banks set. We also examine the implications in several specific settings and show that studying equilibrium agendas can lead to sharp predictions, in contrast with well-known ``chaos'' theorems.agenda, equilibrium, voting, agenda formation
On Galilean invariance and nonlinearity in electrodynamics and quantum mechanics
Recent experimental results on slow light heighten interest in nonlinear
Maxwell theories. We obtain Galilei covariant equations for electromagnetism by
allowing special nonlinearities in the constitutive equations only, keeping
Maxwell's equations unchanged. Combining these with linear or nonlinear
Schroedinger equations, e.g. as proposed by Doebner and Goldin, yields a
Galilean quantum electrodynamics.Comment: 12 pages, added e-mail addresses of the authors, and corrected a
misprint in formula (2.10
Diagnosing hydrological limitations of a land surface model: application of JULES to a deep-groundwater chalk basin
Land surface models (LSMs) are prospective starting points to develop a global hyper-resolution model of the terrestrial water, energy, and biogeochemical cycles. However, there are some fundamental limitations of LSMs related to how meaningfully hydrological fluxes and stores are represented. A diagnostic approach to model evaluation and improvement is taken here that exploits hydrological expert knowledge to detect LSM inadequacies through consideration of the major behavioural functions of a hydrological system: overall water balance, vertical water redistribution in the unsaturated zone, temporal water redistribution, and spatial water redistribution over the catchment's groundwater and surface-water systems. Three types of information are utilized to improve the model's hydrology: (a) observations, (b) information about expected response from regionalized data, and (c) information from an independent physics-based model. The study considers the JULES (Joint UK Land Environmental Simulator) LSM applied to a deep-groundwater chalk catchment in the UK. The diagnosed hydrological limitations and the proposed ways to address them are indicative of the challenges faced while transitioning to a global high resolution model of the water cycle
The implications of COP21 for our future climate
Rising CO2 in the atmosphere is the main cause of anthropogenic climate change, and the data shows a clear increase in global temperature of about 1 °C since pre-industrial levels. Changes in climate extremes are also occurring, with observed increases in the frequency of heat waves, in intense precipitation (rainfall and snowfall) in many places, and in sea level and storm surges. A changing climate with rising extremes has associated risks for food production and other health-related impacts. In order to limit climate change well below 2 °C, our carbon emissions must rapidly follow a decreasing trajectory to near zero
Climate change social learning sandbox
The CGIAR Research Program on Climate Change Agriculture and Food Security (CCAFS) through its theme on Decision Making has since 2010 been exploring what communication and learning approaches might be appropriate in this new and constantly changing context.
Jointly held workshops highlighted that for problems like climate change and
development it is not sufficient to direct experts to evaluate the issue and advise policymakers or affected people how to respond. Instead, we need ongoing, flexible, consultative processes that develop a collective understanding and response. develop a collective understanding and response. One of the outcomes of the workshops was the establishment of a Sandbox as a
mechanism to sustain work on the ideas and activities around Climate Change Social Learning (CCSL) that had surfaced during the workshop
Can core-surface flow models be used to improve the forecast of the Earth's main magnetic field?
[1] Geomagnetic main field models used for navigation are updated every 5 years and contain a forecast of the geomagnetic secular variation for the upcoming epoch. Forecasting secular variation is a difficult task. The change of the main magnetic field is thought to be principally due to advection of the field by flow at the surface of the outer core on short timescales and when large length scales are considered. With accurate secular variation (SV) and secular acceleration (SA) models now available from new satellite missions, inverting for the flow and advecting it forward could lead to a more accurate prediction of the main field. However, this scheme faces two significant challenges. The first arises from the truncation of the observable main field at spherical harmonic degree 13. This can however be handled if the true core flow is large scale and has a rapidly decaying energy spectrum. The second is that even at a given single epoch the instantaneous SV and SA cannot simultaneously be explained by a steady flow. Nevertheless, we find that it may be feasible to use flow models for an improved temporal extrapolation of the main field. A medium-term (≈10 years) hindcast of the field using a steady flow model outperforms the usual extrapolation using the presently observed SV and SA. On the other hand, our accelerated, toroidal flow model, which explains a larger portion of the observed average SA over the 2000–2005 period, fails to improve both the short-term and medium-term hindcasts of the field. This somewhat paradoxical result is related to the occurrence of so-called geomagnetic jerks, the still poorly known dynamical nature of which remains the main obstacle to improved geomagnetic field forecasts
Decomposition of Spectra from Redshift Distortion Maps
We develop an optimized technique to extract density--density and
velocity--velocity spectra out of observed spectra in redshift space. The
measured spectra of the distribution of halos from redshift distorted mock map
are binned into 2--dimensional coordinates in Fourier space so as to be
decomposed into both spectra using angular projection dependence. With the
threshold limit introduced to minimize nonlinear suppression, the decomposed
velocity--velocity spectra are reasonably well measured up to scale k=0.07
h/Mpc, and the measured variances using our method are consistent with errors
predicted from a Fisher matrix analysis. The detectability is extendable to
k\sim 0.1 h/Mpc with more conservative bounds at the cost of weakened
constraint.Comment: 5 pages and 4 figures, submitted to MNRA
Forecasting Cosmological Constraints from Redshift Surveys
Observations of redshift-space distortions in spectroscopic galaxy surveys
offer an attractive method for observing the build-up of cosmological
structure, which depends both on the expansion rate of the Universe and our
theory of gravity. In this paper we present a formalism for forecasting the
constraints on the growth of structure which would arise in an idealized
survey. This Fisher matrix based formalism can be used to study the power and
aid in the design of future surveys.Comment: 7 pages, 5 figures, minor revisions to match version accepted by
MNRA
A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8<sup>+</sup>T cell epitope, NY-ESO-1<sub>88–96</sub> (LEFYLAMPF) and compared its direct- and cross-presentation to that of the reported NY-ESO-1<sub>157–165</sub> epitope restricted to HLA-A*0201. Although both epitopes were readily cross-presented by DCs exposed to various forms of full-length NY-ESO-1 antigen, remarkably NY-ESO-1<sub>88–96</sub> is much more efficiently cross-presented from the soluble form, than NY-ESO-1<sub>157–165</sub>. On the other hand, NY-ESO-1<sub>157–165</sub> is efficiently presented by NY-ESO-1-expressing tumor cells and its presentation was not enhanced by IFN-γ treatment, which induced immunoproteasome as demonstrated by Western blots and functionally a decreased presentation of Melan A<sub>26–35</sub>; whereas NY-ESO-1<sub>88–96</sub> was very inefficiently presented by the same tumor cell lines, except for one that expressed high level of immunoproteasome. It was only presented when the tumor cells were first IFN-γ treated, followed by infection with recombinant vaccinia virus encoding NY-ESO-1, which dramatically increased NY-ESO-1 expression. These data indicate that the presentation of NY-ESO-1<sub>88–96</sub> is immunoproteasome dependent. Furthermore, a survey was conducted on multiple samples collected from HLA-B18+ melanoma patients. Surprisingly, all the detectable responses to NY-ESO-1<sub>88–96</sub> from patients, including those who received NY-ESO-1 ISCOMATRIX™ vaccine were induced spontaneously. Taken together, these results imply that some epitopes can be inefficiently presented by tumor cells although the corresponding CD8<sup>+</sup>T cell responses are efficiently primed in vivo by DCs cross-presenting these epitopes. The potential implications for cancer vaccine strategies are further discussed
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