6,078 research outputs found
Global alliance on vaccines and immunizations. Save the Children UK had concerns about alliance that went further than report did.
Determination of the phase of an electromagnetic field via incoherent detection of fluorescence
We show that the phase of a field can be determined by incoherent detection
of the population of one state of a two-level system if the Rabi frequency is
comparable to the Bohr frequency so that the rotating wave approximation is
inappropriate. This implies that a process employing the measurement of
population is not a square-law detector in this limit. We discuss how the
sensitivity of the degree of excitation to the phase of the field may pose
severe constraints on precise rotations of quantum bits involving low-frequency
transitions. We present a scheme for observing this effect in an atomic beam,
despite the spread in the interaction time.Comment: 4 pages, 2 fig
CLEAR: Cross-Layer Exploration for Architecting Resilience - Combining Hardware and Software Techniques to Tolerate Soft Errors in Processor Cores
We present a first of its kind framework which overcomes a major challenge in
the design of digital systems that are resilient to reliability failures:
achieve desired resilience targets at minimal costs (energy, power, execution
time, area) by combining resilience techniques across various layers of the
system stack (circuit, logic, architecture, software, algorithm). This is also
referred to as cross-layer resilience. In this paper, we focus on
radiation-induced soft errors in processor cores. We address both single-event
upsets (SEUs) and single-event multiple upsets (SEMUs) in terrestrial
environments. Our framework automatically and systematically explores the large
space of comprehensive resilience techniques and their combinations across
various layers of the system stack (586 cross-layer combinations in this
paper), derives cost-effective solutions that achieve resilience targets at
minimal costs, and provides guidelines for the design of new resilience
techniques. We demonstrate the practicality and effectiveness of our framework
using two diverse designs: a simple, in-order processor core and a complex,
out-of-order processor core. Our results demonstrate that a carefully optimized
combination of circuit-level hardening, logic-level parity checking, and
micro-architectural recovery provides a highly cost-effective soft error
resilience solution for general-purpose processor cores. For example, a 50x
improvement in silent data corruption rate is achieved at only 2.1% energy cost
for an out-of-order core (6.1% for an in-order core) with no speed impact.
However, selective circuit-level hardening alone, guided by a thorough analysis
of the effects of soft errors on application benchmarks, provides a
cost-effective soft error resilience solution as well (with ~1% additional
energy cost for a 50x improvement in silent data corruption rate).Comment: Extended version of paper published in Proceedings of the 53rd Annual
Design Automation Conferenc
Impaired autoregulation of renal blood flow in the fawn-hooded rat
The responses to changes in renal perfusion pressure (RPP) were compared
in 12-wk-old fawn-hooded hypertensive (FHH), fawn-hooded low blood
pressure (FHL), and August Copenhagen Irish (ACI) rats to determine
whether autoregulation of renal blood flow (RBF) is altered in the FHH
rat. Mean arterial pressure was significantly higher in conscious,
chronically instrumented FHH rats than in FHL rats (121 +/- 4 vs. 109 +/-
6 mmHg). Baseline arterial pressures measured in
ketamine-Inactin-anesthetized rats averaged 147 +/- 2 mmHg (n = 9) in FHH,
132 +/- 2 mmHg (n = 10) in FHL, and 123 +/- 4 mmHg (n = 9) in ACI rats.
Baseline RBF was significantly higher in FHH than in FHL and ACI rats and
averaged 9.6 +/- 0.7, 7.4 +/- 0.5, and 7.8 +/- 0.9 ml. min-1. g kidney
wt-1, respectively. RBF was autoregulated in ACI and FHL but not in FHH
rats. Autoregulatory indexes in the range of RPPs from 100 to 150 mmHg
averaged 0.96 +/- 0.12 in FHH vs. 0.42 +/- 0.04 in FHL and 0.30 +/- 0.02
in ACI rats. Glomerular filtration rate was 20-30% higher in FHH than in
FHL and ACI rats. Elevations in RPP from 100 to 150 mmHg increased urinary
protein excretion in FHH rats from 27 +/- 2 to 87 +/- 3 microg/min,
whereas it was not significantly altered in FHL or ACI rats. The
percentage of glomeruli exhibiting histological evidence of injury was not
significantly different in the three strains of rats. These results
indicate that autoregulation of RBF is impaired in FHH rats before the
development of glomerulosclerosis and suggest that an abnormality in the
control of renal vascular resistance may contribute to the development of
proteinuria and renal failure in this strain of rats
Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat
The present study examined whether an abnormality in the myogenic response
of renal arterioles that impairs autoregulation of renal blood flow (RBF)
and glomerular capillary pressure (PGC) contributes to the development of
renal damage in fawn-hooded hypertensive (FHH) rats. Autoregulation of
whole kidney, cortical, and medullary blood flow and PGC were compared in
young (12 wk old) FHH and fawn-hooded low blood pressure (FHL) rats in
volume-replete and volume-expanded conditions. Baseline RBF, cortical and
medullary blood flow, and PGC were significantly greater in FHH than in
FHL rats. Autoregulation of renal and cortical blood flow was
significantly impaired in FHH rats compared with results obtained in FHL
rats. Myogenically mediated autoregulation of PGC was significantly
greater in FHL than in FHH rats. PGC rose from 46 +/- 1 to 71 +/- 2 mmHg
in response to an increase in renal perfusion pressure from 100 to 150
mmHg in FHH rats, whereas it only increased from 39 +/- 2 to 53 +/- 1 mmHg
in FHL rats. Isolated perfused renal interlobular arteries from FHL rats
constricted by 10% in response to elevations in transmural pressure from
70 to 120 mmHg. In contrast, the diameter of vessels from FHH rats
increased by 15%. These results indicate that the myogenic response of
small renal arteries is altered in FHH rats, and this contributes to an
impaired autoregulation of renal blood flow and elevations in PGC in this
strain
Benefits to the U.S. from Physicists Working at Accelerators Overseas
We illustrate benefits to the U.S. economy and technological infrastructure
of U.S. participation in accelerators overseas. We discuss contributions to
experimental hardware and analysis and to accelerator technology and
components, and benefits stemming from the involvement of U.S. students and
postdoctoral fellows in global scientific collaborations. Contributed to the
proceedings of the Snowmass 2013 Community Summer Study.Comment: 23 pages, 1 figur
`Zwicky's Nonet': a compact merging ensemble of nine galaxies and 4C 35.06, a peculiar radio galaxy with dancing radio jets
We report the results of our radio, optical and infra-red studies of a
peculiar radio source 4C~35.06, an extended radio-loud AGN at the center of
galaxy cluster Abell 407 (). The central region of this cluster hosts
a remarkably tight ensemble of nine galaxies, the spectra of which resemble
those of passive red ellipticals, embedded within a diffuse stellar halo of
1~arcmin size. This system (named the `Zwicky's Nonet') provides unique
and compelling evidence for a multiple-nucleus cD galaxy precursor.
Multifrequency radio observations of 4C~35.06 with the Giant Meterwave Radio
Telescope (GMRT) at 610, 235 and 150 MHz reveal a system of 400~kpc scale
helically twisted and kinked radio jets and outer diffuse lobes. The outer
extremities of jets contain extremely steep spectrum (spectral index -1.7 to
-2.5) relic/fossil radio plasma with a spectral age of a few yr. Such ultra-steep spectrum relic radio lobes without definitive
hot-spots are rare, and they provide an opportunity to understand the
life-cycle of relativistic jets and physics of black hole mergers in dense
environments. We interpret our observations of this radio source in the context
of the growth of its central black hole, triggering of its AGN activity and jet
precession, all possibly caused by galaxy mergers in this dense galactic
system. A slow conical precession of the jet axis due to gravitational
perturbation between interacting black holes is invoked to explain the unusual
jet morphology.Comment: Published in MNRAS | No. of pages 12, 10 figures and 4 tables.
Comments are welcom
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