B cell reductive therapy with rituximab in the treatment of rheumatoid arthritis.

The approach to treating autoimmune disorders is currently undergoing a significant change in focus. As therapies are developed that are more precise in targeting the pathogenesis for these diseases, patients experience significantly fewer side effects. At the same time, as more precise therapies are discovered, the etiologies of these diseases become further elucidated. It is now widely accepted that B-lymphocytes play a significant role in the pathogenesis of various autoimmune diseases, the extent of which continues to be the focus of ongoing research. Rheumatoid arthritis is one such disease process that has been the focus of various B-lymphocyte-directed therapeutic trials. In this paper we review the current research available on rituximab as treatment for rheumatoid arthritis. This review details results from four main studies, as well as others, which used rituximab in at least one of the arms in treatment of rheumatoid arthritis. The results are promising and will likely lead to longer term studies as well as a potential focus on B cell subsets

SOAP Services with Clarens: Guide for Developers and Administrators

The Clarens application server enables secure, asynchronous SOAP services to run on a Grid cluster such as one of those of the TeraGrid. There is a Client, who wants to use the service and understands the application domain enough to form a reasonable service request; a Developer, who is a power-user of the TeraGrid, who understands both Clarens and the application domain, and creates and deploys a service on a TeraGrid head node; and there is a Root system administrator, who controls the Clarens installation and the cluster on which it runs. The purpose of this document is to provide all of the information a service developer needs to know in order to deploy a Clarens service, with information also provided for the system administrator of the Clarens installation. First we discuss how each of the three roles see the service

Strategic Interactions between Fiscal and Monetary Authorities in a Multi-Country New-Keynesian Model of a Monetary Union

In this paper we consider a number of key issues related to the policy coordination in a monetary union that has been recently discussed in the literature. To this end we propose a multi-country New-Keynesian model of a monetary union cast in the framework of linear quadratic differential games. Our framework can be used to simulate strategic interactions between an arbitrary number of fiscal authorities interacting in coalitions with or against the common central bank. For many parameter combinations our results confirm the findings of Beetsma et al. (2001) that for symmetric inflation and output gap shocks, fiscal coordination between all the countries is counter-productive within a monetary union. The clash between the central bank and the coalition of national governments is most intense under a symmetric inflation shocks when there is strong conflict concerning the orientation of stabilisation policies. This conflict is less pronounced under an asymmetric inflation and output gap shocks, however, still makes fiscal cooperation unattractive. We extend the existing New-Keynesian literature on policy coordination by considering not only cases of non-coordination, fiscal cooperation and the grand coalition, but also the partial cooperation arrangements between fiscal players. We show that, in many cases, partial fiscal coordination of a subgroup of fiscal players is more efficient, from the social point of view, than non-coordination. However, this regime still delivers poor results from the perspective of individual players. This occurs especially in the case of asymmetric shocks, as the countries directly affected by the shocks tend to "export" losses to the countries with whom they form a coalition. Furthermore, we show that the common objective of the grand coalition is of the upmost importance for the outcome of the stabilisation process.macroeconomic stabilisation, EMU, policy coordination, linear quadratic differential games

yourSky: Custom Sky-Image Mosaics via the Internet

yourSky (http://yourSky.jpl.nasa.gov) is a computer program that supplies custom astronomical image mosaics of sky regions specified by requesters using client computers connected to the Internet. [yourSky is an upgraded version of the software reported in Software for Generating Mosaics of Astronomical Images (NPO-21121), NASA Tech Briefs, Vol. 25, No. 4 (April 2001), page 16a.] A requester no longer has to engage in the tedious process of determining what subset of images is needed, nor even to know how the images are indexed in image archives. Instead, in response to a requester s specification of the size and location of the sky area, (and optionally of the desired set and type of data, resolution, coordinate system, projection, and image format), yourSky automatically retrieves the component image data from archives totaling tens of terabytes stored on computer tape and disk drives at multiple sites and assembles the component images into a mosaic image by use of a high-performance parallel code. yourSky runs on the server computer where the mosaics are assembled. Because yourSky includes a Web-interface component, no special client software is needed: ordinary Web browser software is sufficient

Farm Level Incidence of the U.S. Farm Policy Proposal to the WTO

A farm level simulation model is used to analyze the financial impacts of the U.S. proposal to the WTO to reduce farm subsidy payments. The impacts are examined for farms of different sizes, debt positions, and household characteristics. Results indicate that cash flow impacts of the policy change are much greater than net worth impacts.Agricultural and Food Policy,

Deciphering the Atmospheric Composition of WASP-12b: A Comprehensive Analysis of its Dayside Emission

WASP-12b was the first planet reported to have a carbon-to-oxygen ratio (C/O) greater than one in its dayside atmosphere. However, recent work to further characterize its atmosphere and confirm its composition has led to incompatible measurements and divergent conclusions. Additionally, the recent discovery of stellar binary companions ~1" from WASP-12 further complicates the analyses and subsequent interpretations. We present a uniform analysis of all available Hubble and Spitzer Space Telescope secondary-eclipse data, including previously-unpublished Spitzer measurements at 3.6 and 4.5 microns. The primary controversy in the literature has centered on the value and interpretation of the eclipse depth at 4.5 microns. Our new measurements and analyses confirm the shallow eclipse depth in this channel, as first reported by Campo and collaborators and used by Madhusudhan and collaborators to infer a carbon-rich composition. To explain WASP-12b's observed dayside emission spectrum, we implemented several recent retrieval approaches. We find that when we exclude absorption due to C2H2 and HCN, which are not universally considered in the literature, our models require implausibly large atmospheric CO2 abundances, regardless of the C/O. By including C2H2 and HCN in our models, we find that a physically-plausible carbon-rich solution achieves the best fit to the available photometric and spectroscopic data. In comparison, the best-fit oxygen-rich models have abundances that are inconsistent with the chemical equilibrium expectations for hydrogen-dominated atmospheres and are 670 times less probable. Our best-fit solution is also 7.3*10^{6} times more probable than an isothermal blackbody model.Comment: 8 pages, 7 figures, accepted for publication in Ap

Evaluation of Upper Extremity Movement Characteristics during Standardized Pediatric Functional Assessment with a Kinect®-based Markerless Motion Analysis System

A recently developed and evaluated upper extremity (UE) markerless motion analysis system based on the Microsoft® Kinect® has potential for improving functional assessment of patients with hemiplegic cerebral palsy. 12 typically-developing adolescents ages 12-17 were evaluated using both the Kinect-based system and the Shriners Hospitals for Children Upper Extremity Evaluation (SHUEE), a validated measure of UE motion. The study established population means of UE kinematic parameters for each activity. Statistical correlation analysis was used to identify key kinematic metrics used to develop automatic scoring algorithms. The Kinect motion analysis platform is technically sound and can be applied to standardized task-based UE evaluation while providing enhanced sensitivity in clinical analysis and automation through scoring algorithms