Galerie Largeness World of Art

"Galerie Largeness World of Art was a project initiated in September 1996. Each instalment of Galerie Largeness featured works by various artists produced especially for the Galerie. In the span of its thirty issues, Galerie Largeness presented work by some 90 artists, involving various solo and group exhibitions, 5 guest-curated projects, 5 audio-arts projects, one prayer project, one mail-art project, and 3 special events featuring video screenings and performances. [...] Galerie Largeness may reasonably appear to be an art gallery, but one that in its form remained both portable and mutable. Galerie Largeness may appear to be a magazine, but one whose content did not function as reportage, but was in every case work prepared by artists especially for publication at the Galerie. Galerie Largeness may appear to be an archive, in that it presented in a unified context the work characteristic of a determinate time and place. But it was an archive whose scope was neither documentary nor retrospective: the life of Largeness was about the involvement it required on the part of the dozens and dozens of artists and artist-curators who participated in it over the years, and the everyday strategies and negotiations it required to sustain it. [...]" -- Contributor's website

Entre la horca y el cuchillo : la correspondencia de un cacique oaxaqueño : Luis Rodríguez Jacob, 1936-1957

1 archivo PDF (213 páginas)Antología tiene como objetivo difundir un acervo de fuentes que contribuye a explicar la presencia ubicua y el papel fundamental que ha desempeñado el caciquismo en algunas zonas rurales de Oaxaca durante la primera mitad del siglo XX. La antología incluye la correspondencia que Luis Rodríguez Jacob, mejor conocido como el "patriarca y cacique de la Sierra Mixe", sostuvo con varios funcionarios, comerciantes, maestros y campesinos del estado de Oaxaca entre 1936 y 1957. Las cartas, se localizan en los archivos municipales de Santa María Tlahuitoltepec, Mixe, y Tamazulapam del Espíritu Santo, Mixe, Oaxaca, y constituyen el testimonio más completo para comprender la resonancia que tuvo el caciquismo en los pueblos mixes durante el periodo posrevolucionario

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

With the continued emergence of risk loci from Genome-Wide Association studies and variants of uncertain significance identified from patient sequencing, better methods are required to translate these human genetic findings into improvements in public health. Here we combine CRISPR/Cas9 gene editing with an innovative high-throughput genotyping pipeline utilizing KASP (Kompetitive Allele-Specific PCR) genotyping technology to create scarless isogenic cell models of cancer variants in ~1 month. We successfully modeled two novel variants previously identified by our lab in the PALB2 gene in HEK239 cells, resulting in isogenic cells representing all three genotypes for both variants. We also modeled a known functional risk SNP of colorectal cancer, rs6983267, in HCT-116 cells. Cells with extremely low levels of gene editing could still be identified and isolated using this approach. We also introduce a novel molecular assay, ChIPnQASO (Chromatin Immunoprecipitation and Quantitative Allele-Specific Occupation), which uses the same technology to reveal allele-specific function of these variants at the DNA-protein interaction level. We demonstrated preferential binding of the transcription factor TCF7L2 to the rs6983267 risk allele over the non-risk. Our pipeline provides a platform for functional variant discovery and validation that is accessible and broadly applicable for the progression of efforts towards precision medicine

Aviram-Ratner rectifying mechanism for DNA base pair sequencing through graphene nanogaps

We demonstrate that biological molecules such as Watson-Crick DNA base pairs can behave as biological Aviram-Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases. We have performed a parallel computational implementation of the ab-initio non-equilibrium Green's function (NEGF) theory to determine the electrical response of graphene---base-pair---graphene junctions. The results show an asymmetric (rectifying) current-voltage response for the Cytosine-Guanine base pair adsorbed on a graphene nanogap. In sharp contrast we find a symmetric response for the Thymine-Adenine case. We propose applying the asymmetry of the current-voltage response as a sensing criterion to the technological challenge of rapid DNA sequencing via graphene nanogaps

The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics.

Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population

Spin dynamics in a two dimensional quantum gas

We have investigated spin dynamics in a 2D quantum gas. Through spin-changing collisions, two clouds with opposite spin orientations are spontaneously created in a Bose-Einstein condensate. After ballistic expansion, both clouds acquire ring-shaped density distributions with superimposed angular density modulations. The density distributions depend on the applied magnetic field and are well explained by a simple Bogoliubov model. We show that the two clouds are anti-correlated in momentum space. The observed momentum correlations pave the way towards the creation of an atom source with non-local Einstein-Podolsky-Rosen entanglement.Comment: 5 pages, 4 figure