2,917 research outputs found
Mechanism of stimulated Hawking radiation in a laboratory Bose-Einstein condensate
We model a sonic black hole analog in a quasi one-dimensional Bose-Einstein
condensate, using a Gross-Pitaevskii equation matching the configuration of a
recent experiment by Steinhauer [Nat. Phys. 10, 864 (2014)]. The model agrees
well with important features of the experimental observations, demonstrating
their hydrodynamic nature. We find that a zero-frequency bow wave is generated
at the inner (white hole) horizon, which grows in proportion to the square of
the background condensate density. The relative motion of the black and white
hole horizons produces a Doppler shift of the bow wave at the black hole, where
it stimulates the emission of monochromatic Hawking radiation. The mechanism is
confirmed using temporal and spatial windowed Fourier spectra of the
condensate. Mean field behavior similar to that in the experiment can thus be
fully explained without the presence of self-amplifying Hawking radiation.Comment: 24 pages; 19 figure
Importance of composition and hygroscopicity of BC particles to the effect of BC mitigation on cloud properties: Application to California conditions
Black carbon (BC) has many effects on climate including the direct effect on atmospheric absorption, indirect and semi-direct effects on clouds, snow effects, and others. While most of these are positive (warming), the first indirect effect is negative and quantifying its magnitude in addition to other BC feedbacks is important for supporting policies that mitigate BC. We use the detailed aerosol chemistry parcel model of Russell and Seinfeld (1998), observationally constrained by initial measured aerosol concentrations from five California sites, to provide simulated cloud drop number (CDN) concentrations against which two GCM calculations – one run at the global scale and one nested from the global-to-regional scale are compared. The GCM results reflect the combined effects of their emission inventories, advection schemes, and cloud parameterizations. BC-type particles contributed between 16 and 20% of cloud droplets at all sites even in the presence of more hygroscopic particles. While this chemically detailed parcel model result is based on simplified cloud dynamics and does not consider semi-direct or cloud absorption effects, the cloud drop number concentrations are similar to the simulations of both Chen et al. (2010b) and Jacobson (2010) for the average cloud conditions in California. Reducing BC particle concentration by 50% decreased the cloud droplet concentration by between 6% and 9% resulting in the formation of fewer, larger cloud droplets that correspond to a lower cloud albedo. This trend is similar to Chen et al. (2010b) and Jacobson (2010) when BC particles were modeled as hygroscopic. This reduction in CDN in California due to the decrease in activated BC particles supports the concern raised by Chen et al. (2010a) that the cloud albedo effect of BC particles has a cooling effect that partially offsets the direct forcing reduction if other warming effects of BC on clouds are unchanged. These results suggests that for regions like the California sites studied here, where BC mitigation targets fossil fuel sources, a critical aspect of the modeled reduction is the chemical composition and associated hygroscopicity of the BC particles removed as well as their relative contribution to the atmospheric particle concentrations
High-speed imaging and wavefront sensing with an infrared avalanche photodiode array
Infrared avalanche photodiode arrays represent a panacea for many branches of
astronomy by enabling extremely low-noise, high-speed and even photon-counting
measurements at near-infrared wavelengths. We recently demonstrated the use of
an early engineering-grade infrared avalanche photodiode array that achieves a
correlated double sampling read noise of 0.73 e- in the lab, and a total noise
of 2.52 e- on sky, and supports simultaneous high-speed imaging and tip-tilt
wavefront sensing with the Robo-AO visible-light laser adaptive optics system
at the Palomar Observatory 1.5-m telescope. We report here on the improved
image quality achieved simultaneously at visible and infrared wavelengths by
using the array as part of an image stabilization control-loop with
adaptive-optics sharpened guide stars. We also discuss a newly enabled survey
of nearby late M-dwarf multiplicity as well as future uses of this technology
in other adaptive optics and high-contrast imaging applications.Comment: Accepted to Astrophysical Journal. 8 pages, 3 figures and 1 tabl
The effect on photochemical smog of converting the U.S. fleet of gasoline vehicles to modern diesel vehicles
With the increased use of particle traps and nitrogen oxide (NO_x) control devices to reduce air pollution, “modern” diesel vehicles are being encouraged over gasoline vehicles globally as a central method of slowing global warming. Data to date, though, suggest that the NO_2:NO ratio from modern diesel may exceed that of gasoline, and it is difficult to reduce diesel NO_x below gasoline NO_x without increasing particle emissions. Here, it is calculated that, unless the diesel NO_2:NO ratio and total NO_x are reduced to those of gasoline, modern diesel, which should have lower hydrocarbon (HC) and carbon monoxide (CO) emissions than gasoline, may still enhance photochemical smog at the surface and aloft, on average, over the U.S. relative to gasoline. The reason is that vehicle-produced smog in the U.S. depends more on NO_x and the NO_2:NO ratio than on HCs or CO. It is also found that vehicle NO_x controls may be more effective than NO_2:NO ratio controls at reducing ozone
Second generation Robo-AO instruments and systems
The prototype Robo-AO system at the Palomar Observatory 1.5-m telescope is
the world's first fully automated laser adaptive optics instrument. Scientific
operations commenced in June 2012 and more than 12,000 observations have since
been performed at the ~0.12" visible-light diffraction limit. Two new infrared
cameras providing high-speed tip-tilt sensing and a 2' field-of-view will be
integrated in 2014. In addition to a Robo-AO clone for the 2-m IGO and the
natural guide star variant KAPAO at the 1-m Table Mountain telescope, a second
generation of facility-class Robo-AO systems are in development for the 2.2-m
University of Hawai'i and 3-m IRTF telescopes which will provide higher Strehl
ratios, sharper imaging, ~0.07", and correction to {\lambda} = 400 nm.Comment: 11 pages, 4 figures, 3 table
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Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses.
Backgroundthe immune reconstitution inflammatory syndromes (IRIS) are a spectrum of inflammatory conditions associated with opportunistic infections and occurring in approximately16% of human immunodeficiency type 1 (HIV-1)-infected patients given antiretroviral therapy. It has been proposed that these conditions are linked by a dysregulated immune system that is prone to exaggerated responses. However, immunologic studies have been limited by the availability of longitudinal samples from patients with IRIS and appropriate matched control subjects. Cytomegalovirus (CMV) immune recovery uveitis (IRU) is an IRIS occurring in up to 38% of patients with CMV retinitis. Although the pathologic immune responses occur in the eye, immune dysregulation that allows for development of pathologic responses is presumably caused by faulty systemic immune cell reconstitution.Methodswe examined CMV-specific T cell responses, regulatory T (T(reg)) cell function and polyclonal T cell responses, including IL-17 production, in 25 patients with CMV IRU and 49 immunorestored control subjects with CMV retinitis who did not develop IRU.Resultspatients with CMV IRU had poor CMV-specific CD4(+) T cell responses, as compared with control subjects, whereas CD8(+) T cell responses were comparable. Patients with CMV IRU were characterized by smaller numbers of circulating Th17 cells. Deficiency in anti-CMV responses was not associated with differences in T(reg) cell function.Conclusionsthe T(reg) cell compartment is intact in patients with CMV IRU, and these patients do not develop exaggerated systemic CMV-specific or polyclonal immune responses. Cases are instead characterized by more profound depletion of Th17 cells and poor antiviral immune responses. CMV IRU may be most likely to develop in persons experiencing the greatest degree of immune dysfunction before initiating highly active antiretroviral therapy
Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections.
Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions. For segmented RNA viruses like these, novel genotypes can be generated through mutation, recombination, and reassortment. Although it is believed that an ancient recombination event led to the emergence of a new lineage of mammalian arenaviruses, neither recombination nor reassortment has been definitively documented in natural arenavirus infections. Here, we used metagenomic sequencing to survey the viral diversity present in captive arenavirus-infected snakes. From 48 infected animals, we determined the complete or near complete sequence of 210 genome segments that grouped into 23 L and 11 S genotypes. The majority of snakes were multiply infected, with up to 4 distinct S and 11 distinct L segment genotypes in individual animals. This S/L imbalance was typical: in all cases intrahost L segment genotypes outnumbered S genotypes, and a particular S segment genotype dominated in individual animals and at a population level. We corroborated sequencing results by qRT-PCR and virus isolation, and isolates replicated as ensembles in culture. Numerous instances of recombination and reassortment were detected, including recombinant segments with unusual organizations featuring 2 intergenic regions and superfluous content, which were capable of stable replication and transmission despite their atypical structures. Overall, this represents intrahost diversity of an extent and form that goes well beyond what has been observed for arenaviruses or for viruses in general. This diversity can be plausibly attributed to the captive intermingling of sub-clinically infected wild-caught snakes. Thus, beyond providing a unique opportunity to study arenavirus evolution and adaptation, these findings allow the investigation of unintended anthropogenic impacts on viral ecology, diversity, and disease potential
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