न्यू फेरी वार्फ, मुंबई में कोष संपाशों द्वारा एलिपेस जेड्डाबा (फोर्सकल) और मेगालास्पिस कोर्डिला (लिन्नेयस) का असाधारण अवतरण

कृपया पूरा लेखा पढ

Ecological Status and Importance of Grasslands (Vidis) in Conservation of Avian

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Mechanism of Hydrogen-Bonded Complex Formation between Ibuprofen and Nanocrystalline Hydroxyapatite.

Nanocrystalline hydroxyapatite (nanoHA) is the main hard component of bone and has the potential to be used to promote osseointegration of implants and to treat bone defects. Here, using active pharmaceutical ingredients (APIs) such as ibuprofen, we report on the prospects of combining nanoHA with biologically active compounds to improve the clinical performance of these treatments. In this study, we designed and investigated the possibility of API attachment to the surface of nanoHA crystals via the formation of a hydrogen-bonded complex. The mechanistic studies of an ibuprofen/nanoHA complex formation have been performed using a holistic approach encompassing spectroscopic (Fourier transform infrared (FTIR) and Raman) and X-ray diffraction techniques, as well as quantum chemistry calculations, while comparing the behavior of the ibuprofen/nanoHA complex with that of a physical mixture of the two components. Whereas ibuprofen exists in dimeric form both in solid and liquid state, our study showed that the formation of the ibuprofen/nanoHA complex most likely occurs via the dissociation of the ibuprofen dimer into monomeric species promoted by ethanol, with subsequent attachment of a monomer to the HA surface. An adsorption mode for this process is proposed; this includes hydrogen bonding of the hydroxyl group of ibuprofen to the hydroxyl group of the apatite, together with the interaction of the ibuprofen carbonyl group to an HA Ca center. Overall, this mechanistic study provides new insights into the molecular interactions between APIs and the surfaces of bioactive inorganic solids and sheds light on the relationship between the noncovalent bonding and drug release properties

A study of feto-maternal outcome in cases of gestational diabetes mellitus

Background: The aim of the study was to determine prevalence of gestational diabetes mellitus in the community, demographic parameters like age at diagnosis, parity, complications related to gestational diabetes mellitus, and plan the management of gestational diabetes mellitus and to reduce the maternal and perinatal morbidity and mortality. The objective of this study was to evaluate the risk factors and fetomaternal outcome in mothers with gestational diabetes mellitus. Methods: In this prospective cross sectional study we included 120 patients with gestational diabetes mellitus were studied for fetomaternal outcome. The study was conducted from January 2021 to June 2022 at department of obstetrics and gynecology, B. J. Medical College and Civil Hospital, Ahmedabad. Results: Total 120 cases of gestational diabetes mellitus were studied. It was observed that gestational diabetes mellitus were more common in elderly age group (54.16%), multigravida patients were most commonly involved (48.33%). Past history of gestational diabetes mellitus was present in 39.81% of cases, 68.34% of cases required insulin for glycemic control, 63.34% cases required delivery by Caesarean section, maternal complications like preeclampsia (20 cases), polyhydroamnious (44), uteroplacental insufficiency (10), macrosomia, sudden IUFD (7) and operative delivery were common outcome. 12 neonates developed respiratory distress syndrome, 17 developed hypoglycemia and 26 neonates required NICU admission, 12 neonates underwent perinatal mortality. Conclusions: Gestational diabetes mellitus has become a global public health burden. Early detection of gestational diabetes mellitus, timely referral, frequent antenatal visits, and management of the identified cases at tertiary care centers can lead to decreased maternal and feral morbidity and mortality

Drug prescribing pattern in surgical wards of a tertiary care hospital in Western part of India

Background: In surgical wards, drugs are required to manage pain, nausea, vomiting, infections, etc. A growing number of pharmaceutical products are available in present era. Irrational prescribing of drugs is prevalent worldwide. Drug utilization study can be used to assess prescribing patterns. Authors undertook this study to determine current practice of prescribing in surgical wards of the hospital.Methods: Authors conducted observational, noninterventional, descriptive study among patients admitted in surgical wards for one year. Authors have analysed collected data of 604 patients using descriptive statistics to determine utilization pattern of drugs and drug use indicators.Results: Appendicitis (14.9%) followed by hernia (10.6%) were leading diseases for admission. Mean duration of stay was 7.44. Average number of drugs in a prescription was 8.94. Antibiotics (32.07 %), analgesics (17.11 %) and antacids (16.09 %) were leading drug groups prescribed. Amikacin (5.81 %) followed by metronidazole (5.30 %) and ciprofloxacin (5.19 %) were commonly prescribed antimicrobial drugs. Tramadol (5.31 %) and pantoprazole (7.17 %) were leading drugs prescribed from analgesics and antacids respectively. All prescriptions had at least one injectable drug. At least one antibiotic was present in 92.05 % prescriptions. Majority of drugs (87.27 %) were prescribed by generic names. Proportion of drugs prescribed from essential medicine list was 84.22 %.Conclusions: Polypharmacy and injectable drug prescribing were common in practice. There is a scope for improving such prescribing practices among practitioners. Use of multiple antibiotics should be avoided whenever possible and usage should be evidence based

MOLECULAR CHARACTERIZATION OF RICE (ORYZA SATIVA L.) GENOTYPES RESISTANT TO MOISTURE STRESS

RAPD and SSR analysis of 26 genotypes of rice were performed; where RAPD and SSR with 15 and 10 primers amplified a total of 268 and 99 fragments respectively. The dendrogram generated through the study revealed that upland varieties clustered together in cluster A whereas transplanted in cluster B. The varieties with maximum similarity with other genotypes could be used as parents in hybridization programme, to generate maximum variability in segregating generation and increase scope of isolating desirable recombinants

Clockwise torque results in higher reoperation rates in left-sided femur fractures

Purpose: Effects of clockwise torque rotation onto proximal femoral fracture fixation have been subject of ongoing debate: fixated right-sided trochanteric fractures seem more rotationally stable than left-sided fractures in the biomechanical setting, but this theoretical advantage has not been demonstrated in the clinical setting to date. The purpose of this study was to identify a difference in early reoperation rate between patients undergoing surgery for left-versus right-sided proximal femur fractures using cephalomedullary nailing (CMN). Materials and methods: The American College of Surgeons National Surgical Quality Improvement Program was queried from 2016-2019 to identify patients aged 50 years and older undergoing CMN for a proximal femoral fracture. The primary outcome was any unplanned reoperation within 30 days following surgery. The difference was calculated using a Chi-square test, and observed power calculated using post-hoc power analysis. Results: In total, of 20,122 patients undergoing CMN for proximal femoral fracture management, 1.8% (n=371) had to undergo an unplanned reoperation within 30 days after surgery. Overall, 208 (2.0%) were left-sided and 163 (1.7%) right-sided fractures (p=0.052, risk ratio [RR] 1.22, 95% confidence interval [CI] 1.00-1.50), odds ratio [OR] 1.23 (95%CI 1.00-1.51), power 49.2% (& alpha;=0.05). Conclusion: This study shows a higher risk of reoperation for left-sided compared to right-sided proximal femur fractures after CMN in a large sample size. Although results may be underpowered and statistically insignificant, this finding might substantiate the hypothesis that clockwise rotation during implant insertion and (post-operative) weightbearing may lead to higher reoperation rates. Level of evidence: Therapeutic level II.Orthopaedics, Trauma Surgery and Rehabilitatio

From Conventional to Innovation: Abla Bhai’s Seaweed Farming Success Story

Abla Bhai, a dedicated fisherman from Juna Bandar, has been engaged in traditional fishing along the Kutch coast for many years. Despite the hard work, the returns were minimal. With the new HDPE rafts, Abla Bhai saw a significant improvement in his seaweed harvests, leading to higher yields and better quality