Chile Se Moviliza: Protest Movements and Inequality in Post-Dictatorship Chile

On March 11, 1990, Augusto Pinochet, one of Latin America’s most infamous dictators, left office after Chileans ordered him to step down in a nationwide plebiscite. Since Pinochet harshly punished any and all dissenters, protests re-emerged in Chile as a popular form of political action. In this thesis, I examine the relationship between economic and political inequality and the frequency of protests and peaceful demonstrations in the country. I examine the theory behind why people protest, and later examine the history of individual protest movements (such as the Chilean Education Movement). Lastly, I run a regression to evaluate the relationship between GINI coefficient (a popular measure of income inequality) and the frequency of peaceful demonstrations since the end of the dictatorship. Though the regression does not indicate that there is a significant relationship between the two, survey data suggests that Chileans view protest as a legitimate and effective form of political action, and that they have little faith in the government and party system to represent their interests. Thus, I posit that Chileans protest because existing social and political infrastructures are not functioning as they should

Victims of stalking in India: A study of girl college students in Tirunelveli City

The word 'stalking' was not commonly known in India, until Priyadharshini Mattoo's case (1996) hit the headlines. Eve teasing, a colloquial word for gender harassment is popularly known and Tamil Nadu Prohibition of Eve-Teasing Act, 1998 on that was developed after the brutal killing of a girl named Sarika Shah in Chennai. Though, stalking is there in the past, it was not acknowledged with this terminology and it was always merged with Eve teasing. On the other hand, stalking is much graver than Eve teasing and it is an obsessive behaviour. After the Matoo's case, the Indian Criminal Justice System awoke and the National Commission for Women is ready with a draft Bill (Sexual Assault Prevention Bill) to make the Indian Penal Code more effective against the menace of stalkers. Research studies related to stalking in India are sparse and there is a need to study this phenomenon in depth. This paper presents some results from a study of stalking victims among Girl College students at Tirunelveli City, Tamil Nadu, India. In-depth questionnaire data are drawn on to investigate the course and nature of prolonged stalking in 150 self-defined victims. Findings indicate a pattern of repeated intrusions, the stalking harassment methods, lack of reporting behaviour, and effects of stalking on the victims

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.

Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential treatment options for Dravet syndrome. To investigate the serotonin receptors that could moderate this antiepileptic activity, we designed and synthesized 28 novel analogues of clemizole, obtained receptor binding affinity profiles, and performed in vivo screening in a scn1lab mutant zebrafish (Danio rerio) model which recapitulates critical clinical features of Dravet syndrome. We discovered three clemizole analogues with 5-HT receptor binding that exert powerful antiepileptic activity. Based on structure-activity relationships and medicinal chemistry-based analysis, we then screened an additional set of known 5-HT receptor specific drug candidates. Integrating our in vitro and in vivo data implicates 5-HT2B receptors as a critical mediator in the mechanism of seizure suppression observed in Dravet syndrome patients treated with 5-HT modulating drugs

Interfacial viscoelasticity, yielding and creep ringing of globular protein–surfactant mixtures

Protein–surfactant mixtures arise in many industrial and biological systems, and indeed, blood itself is a mixture of serum albumins along with various other surface-active components. Bovine serum albumin (BSA) solutions, and globular proteins in general, exhibit an apparent yield stress in bulk rheological measurements at surprisingly low concentrations. By contrasting interfacial rheological measurements with corresponding interface-free data obtained using a microfluidic rheometer, we show that the apparent yield stress exhibited by these solutions arises from the presence of a viscoelastic layer formed due to the adsorption of protein molecules at the air–water interface. The coupling between instrument inertia and surface elasticity in a controlled stress device also results in a distinctive damped oscillatory strain response during creep experiments known as“creep ringing”. We show that this response can be exploited to extract the interfacial storage and loss moduli of the protein interface. The interfacial creep response at small strains can be described by a simple second order system, such as the linear Jeffreys model, however the interfacial response rapidly becomes nonlinear beyond strains of order 1%. We use the two complementary techniques of interfacial rheometry and microfluidic rheometry to examine the systematic changes in the surface and bulk material functions for mixtures of a common non-ionic surfactant, polysorbate 80, and BSA. It is observed that the nonlinear viscoelastic properties of the interface are significantly suppressed by the presence of even a relatively small amount of surfactant (c[subscript surf] > 10[superscript −3] wt.%). Preferential interfacial adsorption of the mobile surfactant at these surfactant concentrations results in complete elimination of the bulk apparent yield stress exhibited by surfactant-free BSA solutions.Akzo Nobel (Firm

A taxonomy of parallel sorting

TR 84-601In this paper, we propose a taxonomy of parallel sorting that includes a broad range of array and file sorting algorithms. We analyze the evolution of research on parallel sorting, from the earliest sorting networks to the shared memory algorithms and the VLSI sorters. In the context of sorting networks, we describe two fundamental parallel merging schemes - the odd-even and the bitonic merge. Sorting algorithms have been derived from these merging algorithms for parallel computers where processors communicate through interconnection networks such as the perfect shuffle, the mesh and a number of other sparse networks. After describing the network sorting algorithms, we show that, with a shared memory model of parallel computation, faster algorithms have been derived from parallel enumeration sorting schemes, where keys are first ranked and then rearranged according to their rank

Probing hydrogen bond interactions in a shear thickening polysaccharide using nonlinear shear and extensional rheology

Mamaku gum is a polysaccharide extracted from the fronds of the black tree fern found in New Zealand. The cooked pith has traditionally been used for various medicinal purposes and as a food source by the Maori people of New Zealand. It has potential applications as a thickener in the food industry and as a palliative for patients with dysphagia. Studies on the shear rheology of Mamaku gum have revealed that the gum exhibits shear thickening at a critical shear rate due to a transition from intra- to inter-molecular chain interactions upon shear-induced chain elongation. In this paper, we demonstrate that these interactions are primarily due to hydrogen bonding. We perform extensional rheology on mixtures of Mamaku gum and urea (a known disruptor of hydrogen bonds) to quantify the nature of these interactions. Capillary Breakup Extensional Rheometry (CaBER) performed on the pure Mamaku gum solutions yield plateau values of the Trouton ratio as high as ∼10[superscript 4], showing that the viscoelasticity of the gum in uniaxial elongation is much higher than in shear. For all Mamaku concentrations tested, the extensional viscosity decreases upon increasing urea concentration. Furthermore, the relaxation time decreases exponentially with increasing urea concentration. This exponential relationship is independent of the Mamaku concentration, and is identical to the relationships between urea concentration and characteristic timescales measured in nonlinear shear rheology. We show using the sticky reptation model for polymers with multiple sticker groups along the backbone how such a relationship is consistent with a linear decrease in the free energy for hydrogen bond dissociation. We then demonstrate that a time-concentration superposition principle can be used to collapse the viscoelastic properties of the Mamaku-gum/urea mixtures.United States. National Aeronautics and Space Administration (Grant NNX09AV99G

Shear History Extensional Rheology Experiment II (SHERE II) Microgravity Rheology with Non-Newtonian Polymeric Fluids

The primary objective of SHERE II is to study the effect of torsional preshear on the subsequent extensional behavior of filled viscoelastic suspensions. Microgravity environment eliminates gravitational sagging that makes Earth-based experiments of extensional rheology challenging. Experiments may serve as an idealized model system to study the properties of lunar regolith-polymeric binder based construction materials. Filled polymeric suspensions are ubiquitous in foods, cosmetics, detergents, biomedical materials, etc

Donor tricuspid annuloplasty during orthotopic heart transplantation: Long-term results of a prospective controlled study

Background: Development of tricuspid regurgitation after orthotopic heart transplantation can cause heart failure along with renal and hepatic impairment and portends a poor prognosis. If tricuspid regurgitation causes significant symptoms, tricuspid valve repair or replacement is often required. This study was designed to study the effects of prophylactic tricuspid valve annuloplasty (TVA) during orthotopic heart transplantation on long-term survival, renal function, and amount of tricuspid regurgitation. Methods: Between April 1997 and March 1998, 60 patients (aged 18 to 70 years; 22 female) randomly received either standard bicaval orthotopic heart transplantation (group STD; n = 30) or bicaval orthotopic heart transplantation with DeVega TVA (group TVA; n = 30). Tricuspid valve annuloplasty was performed on the donor heart before implantation using pledgeted 2-0 polypropylene and sized to an annulus of 29 mm. Echocardiographic measurements, laboratory values, and hemodynamics were obtained prospectively and reviewed by an independent data analyst. Results: Follow-up of patients as of December 2003 was complete. Although there was a perioperative mortality advantage in group TVA, there was no difference between groups in long-term survival. At the end of the study, however, there was a statistical difference (group STD versus group TVA, p \u3c 0.05) with regard to cardiac mortality (7 of 30 versus 3 of 30), average amount of tricuspid regurgitation (1.5 ± 1.3 versus 0.5 ± 0.4), percentage of patients with 2+ or greater tricuspid regurgitation (34% versus 0%), serum creatinine (2.9 ± 2.0 versus 1.8 ± 0.7), and difference in serum creatinine over baseline (2.0 ± 2.1 versus 0.7 ± 0.8). Conclusions: Prophylactic DeVega TVA of the donor heart is durable and decreases the incidence of cardiac-related mortality and tricuspid regurgitation after orthotopic heart transplantation. In addition, there is improved protection of renal function. Considering the ease and safety of TVA and its advantages, it should be performed as a routine adjunct to orthotopic heart transplantation

Engineered Micro-Environments and Vibrational Culture Systems for Vocal Fold Tissue Engineering

Voice is produced by the conversion of aerodynamic energy from exhalation to acoustical energy for voice production by the vocal folds (membranous connective tissue) located in the larynx. The quality of voice depends on the biomechanical properties of the multi-layered vocal fold tissue which derive from its extracellular matrix (ECM) organization and composition. The wound healing response to vocal fold injuries is characterized by scarring and subsequent dysphonia due to alterations in the biomechanical properties of the tissue. The work presented here is motivated by the importance of voice in maintaining quality of life and the inability of current treatment techniques to restore long-term, normal phonatory voice following injury induced scarring. We hypothesize that vibration is the epigenetic stimulus regulating the unique extracellular matrix (ECM) composition of the human vocal fold tissue and that rapid restoration of the vibratory microenvironment using mechano-mimetic scaffolds will facilitate:- (a) inhibition of scarring and (b) stimulation of fibroblast regeneration of the normal vocal fold tissue architecture/ECM composition and thereby restore long-term, normal phonaory voice. Our objective was to create in situ photopolymerizable, degradable, mechano-mimetic hydrogels/semi-interpenetrating networks (semi-IPNs) which may be introduced into critical size vocal fold defects using minimally invasive methods. Towards this end, we created hyaluronic acid (HA) based hydrogels and polyethylene glycol (PEG)-diacrylate based hydrogels/semi-IPNs, which were found to approximate the viscoelastic mechanical properties of the native human vocal mucosa (vibratory component) and the vocal ligament (strain component), respectively. Cell culture studies indicated that these hydrogel/semi-IPN materials supported cell spreading, cell proliferation, and ECM deposition throughout the 3-dimensional crosslinked network. In an attempt to assess the ability of the HA-based hydrogels to support human fibroblast formation of vocal mucosa-specific matrix in response to physiologically relevant high frequency vibration, fibroblast encapsulated hydrogels were subjected to 2 hrs of vibration per day using a custom built vibrational bioreactor. Our results indicated that the exposure of HA hydrogel-encapsulated fibroblasts to physiologically relevant high frequency vibration stimulated a pattern of gene expression and ECM synthesis (upregulation of GAGs, downregulation of fibrous matrix proteins) consistent with the composition of the human vocal mucosa. In the future, these HA-based hydrogels introduced into the human vocal mucosa during the acute phase of wound healing by minimally invasive methods may bring about regeneration of the native human vocal mucosa ECM composition and thereby restore normal phonation