Effects of temperature in reactive distillation of vapor from non-catalytic pentaerythritol tetradodecanoate (petd) reactor

Pentaerythritol Tetradodecanoate (PETD) is a new ester which used as varnish addictive in magnetic wire production. In many foreign countries, production of PETD has been conducted but in Malaysia, the technology of PETD production still not localized by any Malaysia company. The objective of this research is to study effects of temperature in non-catalytic PETD reactor. Method for experiment of this research is using reactive distillation as unit operation and six different temperatures from 180°C to 230°C will be manipulated. The products from the experiment has been analysed using Gas Chromatography (GC). Results show that at 200°C is an optimum temperature for non-catalyst PETD production. It may observe that at 200°C is the maximum reaction for this production of PETD. So, for best temperature for producing PETD using reactive distillation is at 200°C because at this temperature, there are maximum reaction and higher conversion for PETD. Outcome from this research can be considered as pioneer process in localizing the technology, scale up and commercialization of PETD production

Learning to Segment Breast Biopsy Whole Slide Images

We trained and applied an encoder-decoder model to semantically segment breast biopsy images into biologically meaningful tissue labels. Since conventional encoder-decoder networks cannot be applied directly on large biopsy images and the different sized structures in biopsies present novel challenges, we propose four modifications: (1) an input-aware encoding block to compensate for information loss, (2) a new dense connection pattern between encoder and decoder, (3) dense and sparse decoders to combine multi-level features, (4) a multi-resolution network that fuses the results of encoder-decoders run on different resolutions. Our model outperforms a feature-based approach and conventional encoder-decoders from the literature. We use semantic segmentations produced with our model in an automated diagnosis task and obtain higher accuracies than a baseline approach that employs an SVM for feature-based segmentation, both using the same segmentation-based diagnostic features.Comment: Added more WSI images in appendi

Growth of ARPE Cells on a 3D Printed PLA Scaffold

Forming blood vessels is a common obstacle that is faced when attempting to develop artificial organs. One possible method of overcoming this obstacle is by using a 3D printed material as a scaffold for blood vessel growth. In previous studies, it has been shown that Poly-lactic acid (PLA) is an ideal material for use as a scaffold in tissue engineering applications (Kudryavtseva et al., 2017). The following proof of concept will evaluate the ability of PLA to support cell growth on its surface. Specifically, this project aims to determine its usefulness as a scaffold in the culture of Adult Retinal Pigment Epithelium cells (ARPE-19) in the shape of a blood vessel. This was done by 3D printing scaffolds out of PLA, in both a flat sheet and various shapes to promote tubular cell formation. Cells were then cultured on the scaffolds and incubated for enough time to reach confluency. A viability assay was then conducted to determine the effectiveness of PLA at supporting cell growth. It was found that PLA could support the growth of ARPE-19 cells, but it will be necessary to perform further testing to be able to determine how the different shapes affect the the growth of the cells.Presentation Time: Wednesday, 9-10 a.m

Penerapan Media Pembelajaran Anime Kuroko No Basuke terhadap Minat PJOK Peserta Didik Kelas XI SMK Negeri 1 Kota Kediri

Pendidikan Jasmani, Olahraga, dan Kesehatan (PJOK) adalah mata pelajaran penting yang mendukung kesehatan fisik, mental, dan sosial peserta didik. Namun, rendahnya minat peserta didik terhadap pembelajaran PJOK menjadi tantangan yang harus diatasi. Penelitian ini bertujuan untuk mengkaji pengaruh penggunaan media pembelajaran berbasis Anime Kuroko No Basuke terhadap minat belajar peserta didik kelas XI di SMKN 1 Kota Kediri. Metode penelitian menggunakan eksperimen semu dengan dua kelompok, kelompok eksperimen yang menggunakan Anime dan kelompok kontrol yang menggunakan metode konvensional. Sampel terdiri dari 66 peserta didik yang dipilih secara Purposive Sampling. Analisis data menggunakan SPSS 26 meliputi uji normalitas, homogenitas, dan uji-t. Hasil penelitian menunjukkan peningkatan signifikan pada minat belajar kelompok eksperimen dibandingkan kelompok kontrol. Media pembelajaran Kuroko No Basuke terbukti efektif dalam meningkatkan minat belajar dan dapat menjadi alternatif untuk pembelajaran PJOK yang lebih menarik. &nbsp

Detection of Hydrophilic Coating on Biomedical Devices via Fluorescent Nanoparticles

Coatings are an important component of many medical devices. They can change the characteristics of these medical devices including biocompatibility, lubricity, and effectiveness. Many of Merit Medical’s devices, including their transradial catheter, rely on hydrophilic coating to function properly. The hydrophilic coating found on the introducer sheath comes into direct contact with a patient’s vascular and dermal tissue to ease the insertion of the catheter. An incomplete coating on this device could lead to tissue damage, patient discomfort or pain, and device failure. These coatings are often difficult to detect since the coating is completely colorless. In current practices, the only method used to determine coating presence uses Congo Red, a toxic dye that renders the catheter unusable. If a statistically significant number of these devices fail this test, the entire batch is assumed to be faulty and must be rejected, resulting in the loss of tens of thousands of dollars. Our design aims to introduce a fluorescent additive to the hydrophilic coating to detect the presence of uncoated areas without destroying the device. This additive must also comply with biocompatibility parameters. If successful, this method could be patented and/or implemented in the manufacturing process of this device

Optimization of coral aquaculture (Scleractinia) Montipora digitata

Os recifes de coral representam um dos ecossistemas mais diversos do mundo, com importância crítica para diversos organismos. As pessoas também dependem fortemente deste ecossistema marinho em termos ecológicos, económicos e culturais. No entanto, os recifes de coral estão em declínio devido a vários fatores naturais e antropogénicos como o aquecimento global, a poluição ou a pesca ilegal, com métodos destrutivos. Adicionalmente, a captura de corais selvagens, é uma atividade praticada em várias regiões tropicais e subtropicais, principalmente para indústria de aquariofilia. A aquacultura de corais (in situ ou ex situ) é, portanto, uma possível solução para minimizar a captura de organismos selvagens, possibilitando a produção destes organismos para diversos fins, tais como o repovoamento, construção de recifes artificias, extração de compostos bioativos e comercialização para fins educativos e ornamentais. No entanto, persiste a necessidade de otimizar os procedimentos zootécnicos de forma a maximizar a taxa de sobrevivência e de crescimento. Este trabalho teve como principais objetivos estudar o efeito da luz (intensidade e espetro) na sobrevivência, crescimento, fotobiologia, consumo de energia e reservas energéticas de fragmentos do coral duro Montipora digitata, provenientes de colónias mãe aclimatadas a diferentes cenários de luz (mimetizando diferentes profundidades). Oito colónias (com a mesma origem genética) foram aclimatadas por dois meses em sistemas experimentais com iluminação artificial (espetro total) com duas intensidades de radiação fotossintética ativa (PAR, 70±10 e 130±20 μmol quanta.m-2.s-1, 4 colónias em cada condição). Posteriormente as colónias foram fragmentadas e os fragmentos cultivados durante quatro meses em quatro tratamentos (n=7), utilizando dois espectros de luz (vermelha e azul) com duas intensidades PAR: 130±20 μmol quanta.m-2.s-1 (luz alta) e 70±10 μmol quanta.m-2.s-1 (luz baixa). Durante a experiência não ocorreu mortalidade, mas verificou-se um efeito da origem da colónia e do espetro de luz nos parâmetros analisados. Observou-se que os fragmentos cultivados com espetro de luz vermelha e um PAR 70±10 μmol quanta.m-2.s-1 apresentaram um crescimento mais elevado, quando comparados com os fragmentos cultivados com luz azul. Relativamente aos restantes parâmetros analisados, os resultados sugerem que os fragmentos cultivados em luz vermelha apresentaram de uma forma geral melhores resultados.Coral reefs represent one of the most diverse ecosystems in the world, with critical importance for various organisms. People also depend heavily on this marine ecosystem in ecological, economic and cultural terms. However, coral reefs are declining due to various natural and anthropogenic factors such as global warming, pollution or illegal fishing with destructive gears. In addition, the capture of wild corals is an activity practiced in several tropical and subtropical regions, mainly for the aquarium industry. Coral aquaculture (in situ or ex situ) is, therefore, a possible solution to minimize the capture of wild organisms, allowing the production of these organisms for various purposes, such as transplantation and restocking to accelerate the recovery of coral reefs, artificial reef building, extraction of bioactive compounds and commercialization for educational and ornamental purposes. However, the need to optimize zootechnical procedures persists in order to maximize survival and growth rates. The main objective of this work was to study the effect of light (intensity and spectra) on survival, growth, photobiology, energy consumption and energy reserves of scleractinian coral Montipora digitata fragments, obtained from mother colonies acclimated to different light scenarios (mimicking different sea depths). Eight colonies (with the same genetic origin) were acclimated for two months in experimental systems with artificial light (total spectrum) with two intensities of active photosynthetic radiation (PAR, 70±10 and 130±20 μmol quanta.m-2.s-1, 4 colonies in each condition). Afterward, colonies were fragmented and the fragments were cultured for four months in four treatments (n = 7), using two light spectra (red and blue) with two PAR intensities: 130±20 μmol quanta.m-2 .s-1 (high light) and 70±10 μmol quanta.m-2.s-1 (low light). No mortality occurred during the experiment, but an effect of the colony origin and the light spectrum was verified on the analyzed parameters. It was observed that fragments reared with the red light spectrum and a PAR 70±10 μmol quanta.m- 2.s-1 showed higher growth, when compared with the fragments cultured with blue light. Besides growth, results suggest that fragments reared in red light showed better results in the remaining evaluated parameters.Mestrado em Biologia Marinh

PDGFRA/NG2 glia generate new oligodendrocytes but few astrocytes in a murine EAE model of demyelinating disease

The adult mammalian brain and spinal cord contain glial precursors that express platelet-derived growth factor receptors (alpha subunit, PDGFRA) and the NG2 proteoglycan. These “NG2 cells” descend from oligodendrocyte precursors in the perinatal CNS and continue to generate myelinating oligodendrocytes in the grey and white matter of the postnatal brain. It has been proposed that NG2 cells can also generate reactive astrocytes at sites of CNS injury or demyelination. To test this we examined the fates of PDGFRA/ NG2 cells in the mouse spinal cord during experimental autoimmune encephalomyelitis (EAE) - a demyelinating condition that models some aspects of multiple sclerosis in humans. We administered tamoxifen to Pdgfra-CreERT2: Rosa26R-YFP mice in order to induce yellow fluorescent protein (YFP) expression in PDGFRA/ NG2 cells and their differentiated progeny. We subsequently induced EAE and observed a large (>4-fold) increase in the density of YFP+ cells, >90% of which were oligodendrocyte lineage cells. Many of these became CC1-positive, NG2-negative differentiated oligodendrocytes that expressed myelin markers CNP and Tmem10/ Opalin. PDGFRA/ NG2 cells generated very few GFAP+ reactive astrocytes (1-2% of all YFP+ cells) or NeuN+neurons (<0.02%). Thus, PDGFRA/ NG2 cells act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord

Keberkesanan EQ-maze dalam meningkatkan minat dan pencapaian pelajar / Kherul Jefri Jamen ... [et al.]

Objectives of this invention is to expand the effectiveness in booking process from manual to database system through Ez-BP at Perpustakaan Sultan Badlishah UiTM (PSB) Kedah. In order to sustain and shared the new invention, PSB served and provided the reservation for discussion room to end user especially student in a short time which is cover the Surging Ahead Through Creativity. The culture of invention will prepare us to innovate and try to commercialize. The novelty and the uniqueness of Ez-BP are affected to the technologies usage and the implementation will carry out a platform which is more easily, full of integrity that’s related to end user (reduce bias's issue and highly fairness). This invention can get immediate feedback. “Ez-BP” provide the great impact by saving times, reduces budget for paper and system, implement green environment (paperless) and also provided the original data because it’s cannot be altered. Commercialization aspect that could be consider is to offer the consultation’s services for build up this booking platform thought out the academic lifestyle that affected to student and culture. The inventions of the flow in reservation’s process always looks simple but without an invention or creativity, the implementation and the process will be routine and manually. There will no relationship among workflow and the invention or new technologies involve especially in academic fields. So, as a conclusion, this invention of Ez-BP was really needed because we need the learning process that can contribute to the novelty and uniqueness as mentioned

Evaluation of occupational exposure to TiO2 nanoparticles: microwave-assisted acid digestion method on air membrane filters

Titanium dioxide (TiO2) nanoparticles have been extensively used in various industrial sectors and applications, including cosmetics, catalysts, food additives, inks, paints, and coatings. However, the International Agency for Research on Cancer (IARC) has classified TiO2 nanoparticles as a potential carcinogen for humans, meaning they may cause cancer and pose serious health complications, particularly for manufacturing workers. This highlights the need for better evaluation to determine worker exposure. In this study, suspended TiO2 nanoparticles were sampled using a nanoparticle respiratory deposition (NRD) sampler fitted with specially designed membrane filters and analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The digestion method used for titanium element recovery after nanoparticle sampling is crucial for optimal ICP-MS analysis. Therefore, this study aimed to investigate the most suitable digestion method. A microwave-acid digestion method using concentrated nitric acid and concentrated hydrochloric acid at a 7:4 ratio, with a run time of 30 minutes and the temperature set to 200°C showed remarkable titanium recovery compared to other methods. These findings may pave the way for optimal analysis of suspended TiO2 nanoparticles in assessing occupational exposure while promoting sustainability and eco-friendliness in resource utilization