Survey of vector-like fermion extensions of the Standard Model and their phenomenological implications

With the renewed interest in vector-like fermion extensions of the Standard Model, we present here a study of multiple vector-like theories and their phenomenological implications. Our focus is mostly on minimal flavor conserving theories that couple the vector-like fermions to the SM gauge fields and mix only weakly with SM fermions so as to avoid flavor problems. We present calculations for precision electroweak and vector-like state decays, which are needed to investigate compatibility with currently known data. We investigate the impact of vector-like fermions on Higgs boson production and decay, including loop contributions, in a wide variety of vector-like extensions and their parameter spaces.Comment: 43 pages, 17 figures; v2: text modified to improve readability, references added, journal versio

Toward understanding ambulatory activity decline in Parkinson disease

BACKGROUND: Declining ambulatory activity represents an important facet of disablement in Parkinson disease (PD). OBJECTIVE: The primary study aim was to compare the 2-year trajectory of ambulatory activity decline with concurrently evolving facets of disability in a small cohort of people with PD. The secondary aim was to identify baseline variables associated with ambulatory activity at 1- and 2-year follow-up assessments. DESIGN: This was a prospective, longitudinal cohort study. METHODS: Seventeen people with PD (Hoehn and Yahr stages 1-3) were recruited from 2 outpatient settings. Ambulatory activity data were collected at baseline and at 1- and 2-year annual assessments. Motor, mood, balance, gait, upper extremity function, quality of life, self-efficacy, and levodopa equivalent daily dose data and data on activities of daily living also were collected. RESULTS: Participants displayed significant 1- and 2-year declines in the amount and intensity of ambulatory activity concurrently with increasing levodopa equivalent daily dose. Worsening motor symptoms and slowing of gait were apparent only after 2 years. Concurrent changes in the remaining clinical variables were not observed. Baseline ambulatory activity and physical performance variables had the strongest relationships with 1- and 2-year mean daily steps. LIMITATIONS: The sample was small and homogeneous. CONCLUSIONS: Future research that combines ambulatory activity monitoring with a broader and more balanced array of measures would further illuminate the dynamic interactions among evolving facets of disablement and help determine the extent to which sustained patterns of recommended daily physical activity might slow the rate of disablement in PD.This study was funded primarily by the Davis Phinney Foundation and the Parkinson Disease Foundation. Additional funding was provided by Boston University Building Interdisciplinary Research Careers in Women's Health (K12 HD043444), the National Institutes of Health (R01NS077959), the Utah Chapter of the American Parkinson Disease Association (APDA), the Greater St Louis Chapter of the APDA, and the APDA Center for Advanced PD Research at Washington University. (Davis Phinney Foundation; Parkinson Disease Foundation; K12 HD043444 - Boston University Building Interdisciplinary Research Careers in Women's Health; R01NS077959 - National Institutes of Health; Utah Chapter of the American Parkinson Disease Association (APDA); Greater St Louis Chapter of the APDA; APDA Center for Advanced PD Research at Washington University

QCD corrections to stoponium production at hadron colliders

If the lighter top squark has no kinematically allowed two-body decays that conserve flavor, then it will live long enough to form hadronic bound states. The observation of the diphoton decays of stoponium could then provide a uniquely precise measurement of the top squark mass. In this paper, we calculate the cross section for the production of stoponium in a hadron collider at next-to-leading order (NLO) in QCD. We present numerical results for the cross section for production of stoponium at the LHC and study the dependence on beam energy, stoponium mass, and the renormalization and factorization scale. The cross-section is substantially increased by the NLO corrections, counteracting a corresponding decrease found earlier in the NLO diphoton branching ratio.Comment: 24 page

Can decaying modes save void models for acceleration?

The unexpected dimness of Type Ia supernovae (SNe), apparently due to accelerated expansion driven by some form of dark energy or modified gravity, has led to attempts to explain the observations using only general relativity with baryonic and cold dark matter, but by dropping the standard assumption of homogeneity on Hubble scales. In particular, the SN data can be explained if we live near the centre of a Hubble-scale void. However, such void models have been shown to be inconsistent with various observations, assuming the void consists of a pure growing mode. Here it is shown that models with significant decaying mode contribution today can be ruled out on the basis of the expected cosmic microwave background spectral distortion. This essentially closes one of the very few remaining loopholes in attempts to rule out void models, and strengthens the evidence for Hubble-scale homogeneity.Comment: 11 pages, 3 figures; discussion expanded, appendix added; version accepted to Phys. Rev.

A survey of rabbit handling methods within the United Kingdom and the Republic of Ireland

Rabbits are commonly kept in a variety of settings, including homes, laboratories, and veterinary clinics. Despite the popularity of keeping this prey species, little research has investigated current methods of handling. The aim of this study was to examine the experience of caregivers (owners and keepers) in using five handling methods commonly referred to in books written for companion animal (pet) owners and veterinary and/or laboratory personnel. An online survey was completed by 2644 respondents, representing all three of these groups, and breeders. Data were acquired to determine sources that participants used to gain knowledge of different handling methods, the methods they used and for what purposes they used them, and their perceptions of any associated difficulties or welfare concerns. Results indicated that participants most frequently used the method of supporting a rabbit’s body against a person’s chest, which was considered the easiest and most welfare-friendly method of the handling methods explored. “Scruffing with rear support” was the least used method and was considered to be distressing and painful for the rabbit. As rabbits are a terrestrial prey species, being picked up is likely an innately stressful experience. Additional research is encouraged to explore the experience of rabbits during handling to identify methods that can be easily used with the fewest welfare compromises

Wafer-Level Parylene Packaging With Integrated RF Electronics for Wireless Retinal Prostheses

This paper presents an embedded chip integration technology that incorporates silicon housings and flexible Parylene-based microelectromechanical systems (MEMS) devices. Accelerated-lifetime soak testing is performed in saline at elevated temperatures to study the packaging performance of Parylene C thin films. Experimental results show that the silicon chip under test is well protected by Parylene, and the lifetime of Parylenecoated metal at body temperature (37°C) is more than 60 years, indicating that Parylene C is an excellent structural and packaging material for biomedical applications. To demonstrate the proposed packaging technology, a flexible MEMS radio-frequency (RF) coil has been integrated with an RF identification (RFID) circuit die. The coil has an inductance of 16 μH with two layers of metal completely encapsulated in Parylene C, which is microfabricated using a Parylene–metal–Parylene thin-film technology. The chip is a commercially available read-only RFID chip with a typical operating frequency of 125 kHz. The functionality of the embedded chip has been tested using an RFID reader module in both air and saline, demonstrating successful power and data transmission through the MEMS coil

Balance differences in people with Parkinson disease with and without freezing of gait

Published in final edited form as: Gait Posture. 2015 September ; 42(3): 306–309. doi:10.1016/j.gaitpost.2015.06.007.BACKGROUND: Freezing of gait (FOG) is a relatively common and remarkably disabling impairment associated with Parkinson disease (PD). Laboratory-based measures indicate that individuals with FOG (PD+FOG) have greater balance deficits than those without FOG (PD-FOG). Whether such differences also can be detected using clinical balance tests has not been investigated. We sought to determine if balance and specific aspects of balance, measured using Balance Evaluation Systems Test (BESTest), differs between PD+FOG and PD-FOG. Furthermore, we aimed to determine if time-efficient clinical balance measures (i.e. Mini-BESTest, Berg Balance Scale (BBS)) could detect balance differences between PD+FOG and PD-FOG. METHODS: Balance of 78 individuals with PD, grouped as either PD+FOG (n=32) or PD-FOG (n=46), was measured using the BESTest, Mini-BESTest, and BBS. Between-groups comparisons were conducted for these measures and for the six sections of the BESTest using analysis of covariance. A PD composite score was used as a covariate. RESULTS: Controlling for motor sign severity, PD duration, and age, PD+FOG had worse balance than PD-FOG when measured using the BESTest (p=0.008, F=7.35) and Mini-BESTest (p=0.002, F=10.37), but not the BBS (p=0.27, F=1.26). BESTest section differences were noted between PD+FOG and PD-FOG for reactive postural responses (p<0.001, F=14.42) and stability in gait (p=0.003, F=9.18). CONCLUSIONS: The BESTest and Mini-BESTest, which specifically assessed reactive postural responses and stability in gait, were more likely than the BBS to detect differences in balance between PD+FOG and PD-FOG. Because it is more time efficient to administer, the Mini-BESTest may be the preferred tool for assessing balance deficits associated with FOG.This study was conducted with funding from the Davis Phinney Foundation, Parkinson's Disease Foundation, NIH R01 NS077959, NIH UL1 TR000448, Greater St. Louis American Parkinson Disease Association (APDA), APDA Center for Advanced PD Research at Washington University in St. Louis. The funding sources had no role in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. (Davis Phinney Foundation; Parkinson's Disease Foundation; R01 NS077959 - NIH; UL1 TR000448 - NIH; Greater St. Louis American Parkinson Disease Association (APDA); APDA Center for Advanced PD Research at Washington University in St. Louis

A survey of common rabbit handling methods and reasons for their use

Rabbits are both popular pets commonly seen within veterinary practices, and frequently used in laboratories in the United Kingdom and elsewhere. However, to date there is minimal research that has investigated why and how people handle rabbits and why they choose to use such methods. In addition, few studies have considered the sources individuals use to learn about rabbit handling and their reasons to not use specific handling methods

A review of handling methods of rabbits within pet, laboratory and veterinary contexts

Rabbits are considered to be the third most frequently kept pet in the UK as well as being utilised for medical and veterinary research. Despite this, little research has been conducted on rabbit handling methods. A literature review was conducted that focused directly on proposed handling methods of rabbits within different contexts. This included books where specific handling sections could be identified which were produced for pet owners, veterinary staff and laboratory staff. A range of textbooks were selected between the years [2000–2015] that were available on both Google books and Amazon. To identify the recommended handling methods and evaluate information available the following was recorded; number of handling and restraint methods described, justification for suggested methods, identification of inappropriate handling methods and relevant details, word count, use of images and any recommended equipment and its use (e.g. towel to avoid kicking or reduce stress). In total 20 books were reviewed, ten pet rabbit, seven veterinary animal/rabbit and three laboratory animal/rabbit books. Results indicate that recommended handling methods differ between contexts and that there is some confusion about the use of some methods, such as scruffing and ‘Tonic Immobility’, which have been noted to potentially be stressful. Some methods, such as picking a rabbit up by the ears, were consistently considered inappropriate. The authors describe research currently being undertaken and highlight the need for further research such as investigating handling methods and associated educational material provided by rescue centres and pet shops before, during and after the point of purchase/rehoming