Advanced methods for safe visualization on automotive displays

Camera Monitor Systems (CMSs), for example, for backup cameras or mirror replacements, become increasingly important and already cover safety aspects such as guaranteed latency and no frame freeze. Today\u27s approaches deal only with supervision of the digital interface, LCD backlight, and power supply. This paper introduces methods for advanced safety monitoring of panel electronics and optical display output that aim to enable future CMS based automotive use cases. Our methods are based on correlation of physical measurements with predicted values derived from a corresponding display model. This model was made via calibration measurements and many test patterns. Correlation of the monitoring results with predicted values corresponds to the probability that the RGB data are shown as intended. This implies that an overlying system, an Automotive Safety Integrity Level (ASIL) Prepared Video Safety System (APVSS), ensures that only safety verified RGB data are provided to the panel electronics. In case of failures, our methods enable a safe system state, for example, by deactivating the panel. An additional challenge is to allow graceful degradations, a safe but slightly degraded image may provide a better customer experience compared with no information. We successfully verified our approach by a fully functional prototype and extensive evaluation towards “light-to-light” (camera to display output) supervision

Payers' views of the changes arising through the possible adoption of adaptive pathways

Payers are a major stakeholder in any considerations and initiatives concerning adaptive licensing of new medicinal products, also referred to as Medicines Adaptive Pathways to patients (MAPPs). Firstly, the scope and necessity of MAPPs need further scrutiny, especially with regard to the definition of unmet need. Conditional approval pathways already exist for new medicines for seriously debilitating or life-threatening diseases and only a limited number of new medicines are innovative. Secondly, MAPPs will result in new medicines on the market with limited evidence about their effectiveness and safety. Additional data are to be collected after approval. Consequently, adaptive pathways may increase the risk of exposing patients to ineffective or unsafe medicines. We have already seen medicines approved conventionally that subsequently proved ineffective or unsafe amongst a wider, more co-morbid population as well as medicines that could have been considered for approval under MAPPs but subsequently proved ineffective or unsafe in Phase III trials and were never licensed. Thirdly, MAPPs also put high demands on payers. Routine collection of patient level data is difficult with high transaction costs. It is not clear who will fund these. Other challenges for payers include shifts in the risk governance framework, implications for evaluation and HTA, increased complexity of setting prices, difficulty with ensuring equity in the allocation of resources, definition of responsibility and liability and implementation of stratified use. Exit strategies also need to be agreed in advance, including price reductions, rebates, or reimbursement withdrawals when price premiums are not justified. These issues and concerns will be discussed in detail including potential ways forward

Detection of Spirocerca lupi and an unknown Trichinella-like nematode in raccoon (Procyon lotor).

The raccoon Procyon lotor (Carnivora: Procyonidae) is an invasive species of growing importance for the introduction of alien pathogens or as additional hosts for autochthonous pathogens in Europe, including zoonotic parasites. As the population is steadily increasing and outcompeting the red fox (Vulpes vulpes) in Germany, the consumption of raccoon meat raises concerns about pathogens they may transmit. Therefore the presence of Trichinella larvae was here investigated in muscle samples (n = 904) of raccoons from northern Germany. No Trichinella larvae were found, thus confirming the general low occurrence of this parasite in Germany. However, Spirocerca lupi (n = 12) and an unidentified Trichinella-like nematode (n = 1) were accidently detected in the examined samples. The first is not a zoonotic parasite but has a high veterinary relevance as it can cause severe diseases in dogs. It is the first documented autochthonous infection of this nematode in Germany. The larvae of an unidentified Trichinella-like nematode were found in high abundance in all examined muscles of one raccoon, though they could not be identified to species level. Histological investigation revealed intramuscular cystic structures. This is the largest study investigating muscular parasites of raccoons in Europe so far, which suggests that this invasive animal species is infected by S. lupi and by a yet unknown Trichinella -like parasite

Methode zur kostenoptimalen Losgrößenbildung unter der Berücksichtigung des Verschleißes

Werkzeugverschleiß ist für Schmiedeunternehmen von großer wirtschaftlicher Relevanz. Neben den Instandhaltungskosten fallen ebenfalls Kosten für verschleißabhängige Ausschussteile an. Im Zuge des Forschungsprojektes „Verfahren zur kostenoptimalen Losgrößenbildung unter Berücksichtigung des Verschleißes von Schmiedewerkzeugen“ wurde eine Methode zur Ermittlung bauteilindividueller Kostenfunktionen in Abhängigkeit des Verschleißes entwickelt. Die Methode ermöglicht die Bestimmung einer Losgröße, mit der eine maximale Kosteneinsparung erzielt werden kann.Tool wear is of great economic relevance for forging companies. In addition to the maintenance costs, wear-related rejects are also produced. In the course of the research project “Processes for lot sizing planning in consideration of abrasion”, a method was developed for the determination of component-specific cost functions depending on the tool wear. The method allows the determination of a lot size, that leads to a most cost saving production

Undertaking Doctoral Research with Children and Young People with Life-limiting or Life-threatening Conditions

Doctoral level research can contribute to the evidence base, particularly in under‐researched areas and numerically small fields such as children and young people's palliative care. It is acknowledged that much of what we currently do in children's and young people's palliative care is eminence‐based, rather than evidence‐based (Together for Short Lives, 2018). Whilst sharing experience and wisdom was valuable, particularly when the specialty was in its infancy, it is important now to develop an evidence base to ensure that children, young people and their families receive the highest standard of care. This requires fostering the development of a research culture, including trained clinical and non‐clinical researchers, who will pursue a penetrating and rigorous research agenda (Beecham et al., 2016)

Investigation of the prediction accuracy of a finite element analysis model for the coating thickness in cross-wedge rolled coaxial hybrid parts

The Collaborative Research Centre 1153 (CRC 1153) "Process chain for the production of hybrid high-performance components through tailored forming" aims to develop new process chains for the production of hybrid bulk components using joined semi-finished workpieces. The subproject B1 investigates the formability of hybrid parts using cross-wedge rolling. This study investigates the reduction of the coating thickness of coaxially arranged semi-finished hybrid parts through cross-wedge rolling. The investigated parts are made of two steels (1.0460 and 1.4718) via laser cladding with hot-wire. The rolling process is designed by finite element (FE)-simulations and later experimentally investigated. Research priorities include investigations of the difference in the coating thickness of the laser cladded 1.4718 before and after cross-wedge rolling depending on the wedge angle β, cross-section reduction DA, and the forming speed v. Also, the simulations and the experimental trials are compared to verify the possibility of predicting the thickness via finite element analysis (FEA). The main finding was the ability to describe the forming behavior of coaxially arranged hybrid parts at a cross-section reduction of 20% using FEA. For a cross-section reduction of 70% the results showed a larger deviation between simulation and experimental trials. The deviations were between 0.8% and 26.2%. © 2019 by the authors

Ganzheitliche Betrachtung der Ökologie und Logistikleistung von KMU

Die CO2-Emission der Logistikbranche und die resultierende Umweltbelastung sind als fortlaufend ansteigend zu konstatieren. Steigende Kosten für Energie und Ressourcen, erhöhte Sensibilität der Kunden, veränderte Gesetzesgrundlagen und der bevorstehende Klimawandel zwingen produzierende Unternehmen zu ökologieorientiertem Umdenken. Die fehlende Kenntnis über Wirkzusammenhänge, quantitative Auswirkungen von Maßnahmen und der Parameterausprägung hindern insbesondere KMU an der Umsetzung. Ein ganzheitliches ökologisch-logistisches Wirkmodell mit softwaretechnischer Umsetzung kann KMU dabei helfen, ihr Potential auszuschöpfen. Anforderungen an das Modell und grundlegende Beziehungen von logistischen Parametern zu ökologischen Zielgrößen werden in dieser Veröffentlichung vorgestellt.The CO2 emissions of the logistics sector and the resulting environmental impact are continuously increasing. Rising costs for energy and resources, increased sensitivity of customers, changed legal bases and the impending climatic change force producing enterprises to ecologically-oriented rethink. The lack of knowledge about interdependencies, quantitative effects of actions and parameter characteristics prevents SMEs from the implementation. A holistic ecological-logistical impact model with software implementation can support SMEs reaching their potential. Requirements for the model and fundamental relationships between logistic parameters and ecological target values are presented in this publication

Simulation assisted process chain design for the manufacturing of bulk hybrid shafts with tailored properties

To manufacture semi-finished hybrid workpieces with tailored properties, a finite element simulation assisted process chain design was investigated. This includes the process steps of cross wedge rolling, hot geometry inspection, induction hardening, and fatigue testing. The process chain allows the utilisation of material combinations such as high-strength steels with low-cost and easy to process steels. Here, plasma transferred arc welding is applied to supply the process chain with hybrid specimen featuring different steel grades. An overview of the numerical approaches to consider the various physical phenomena in each of the process steps is presented. The properties of the component behaviour were investigated via the finite element method (FEM) and theoretical approaches. At first, the manufacturing of a hybrid workpiece featuring a near net shape geometry with improved mechanical properties due to recrystallising the weld was computed, using the example of a cross wedge rolling process. The rolling process was designed by means of FEM to determine suitable process parameters and to reduce experimental testing. An optical multi-scale geometry inspection of the hot workpiece is meant to be carried out after each manufacturing step to detect potential undesired forming or cooling-induced deformations. Due to the heat transfer from the hot component to the ambient medium, an optical measurement is affected by the developing inhomogeneous refractive index field in air. To gain a basic understanding of the refractive index field and induced light deflection effects, computations were conducted using heat transfer and ray tracing simulations. According to the proposed process route, a subsequent local heat treatment of the hybrid component is required to adapt the mechanical properties by a spray cooling assisted induction hardening. The heat treatment step was computed via a 2D FEM calculation. After finishing by machining, the hybrid material shafts are examined in fatigue tests under load conditions. To predict the component’s lifetime under rolling contact fatigue, a damage accumulation model was combined with an FE simulation. The resulting residual stress state after quenching and the geometry after the finishing process were used as input data for the fatigue life calculations

Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction

OBJECTIVE: Evaluation of the quantitative accuracy of MR-based attenuation correction (MRAC) in the Philips Ingenuity TF whole-body PET/MR. MATERIALS AND METHODS: In 13 patients, PET emission data from the PET/MR were reconstructed using two different methods for attenuation correction. In the first reconstruction, the vendor-provided standard MRAC was used. In the second reconstruction, a coregistered transmission-based attenuation map from a second immediately preceding investigation with a stand-alone Siemens ECAT EXACT HR(+) PET scanner was used (TRAC). The two attenuation maps were compared regarding occurrence of segmentation artifacts in the MRAC procedure. Standard uptake values (SUVs) of multiple VOIs (liver, cerebellum, hot focal structures at various locations in the trunk) were compared between both reconstructed data sets. Furthermore, a voxel-wise intensity correlation analysis of both data sets in the lung and trunk was performed. RESULTS: VOI averaged SUV differences between MRAC and TRAC were as follows (relative differences, mean ± standard deviation): (+12 ± 6) % cerebellum, (−4 ± 9) % liver, (−2 ± 11) % hot focal structures. The fitted slopes of the voxel-wise correlations in the lung and trunk were 0.87 ± 0.17 and 0.95 ± 0.10 with averaged adjusted R(2) values of 0.96 and 0.98, respectively. These figures include two instances with partially erroneous lung segmentation due to artifacts in the underlying MR images. CONCLUSION: The MR-based attenuation correction implemented on the Philips Ingenuity PET/MR provides reasonable quantitative accuracy. On average, deviations from TRAC-based results are small (on the order of 10 %  or below) across the trunk, but due to interindividual variability of the segmentation quality, deviations of more than 20 %  can occur. Future improvement of the segmentation quality would help to increase the quantitation accuracy further and to reduce the inter-subject variability