The Man Who Mistook His Neuropsychologist For a Popstar: When Configural Processing Fails in Acquired Prosopagnosia

We report the case of an individual with acquired prosopagnosia who experiences extreme difficulties in recognizing familiar faces in everyday life despite excellent object recognition skills. Formal testing indicates that he is also severely impaired at remembering pre-experimentally unfamiliar faces and that he takes an extremely long time to identify famous faces and to match unfamiliar faces. Nevertheless, he performs as accurately and quickly as controls at identifying inverted familiar and unfamiliar faces and can recognize famous faces from their external features. He also performs as accurately as controls at recognizing famous faces when fracturing conceals the configural information in the face. He shows evidence of impaired global processing but normal local processing of Navon figures. This case appears to reflect the clearest example yet of an acquired prosopagnosic patient whose familiar face recognition deficit is caused by a severe configural processing deficit in the absence of any problems in featural processing. These preserved featural skills together with apparently intact visual imagery for faces allow him to identify a surprisingly large number of famous faces when unlimited time is available. The theoretical implications of this pattern of performance for understanding the nature of acquired prosopagnosia are discussed.DY, Avery Braun, Jacob Waite, and Nadine Wanke, Bruno Rossion, Thomas Busigny and the grant awarded by AJ by the Experimental Psychology Society (EPS

The effects of a modest dose of alcohol on executive functioning and prospective memory

Rationale Acute alcohol intoxication selectively impairs executive functioning and prospective memory (PM). Much previous researches in this area have used laboratory-based tasks that may not mimic functions that individuals with dysexecutive syndrome have problems with in their everyday life. The present study aimed to assess the effects of a modest dose of alcohol on executive functioning and PM using a virtual reality task and investigate the role of executive planning in PM performance. Methods Forty healthy participants were administered 0.4 g/kg alcohol or matched placebo in a double-blind design. Executive function and PM were assessed using the Jansari–Agnew–Akesson–Murphy (JAAM) task, requiring participants to play the role of an office worker. Results Alcohol intoxication selectively impaired executive function and PM. The participants in the alcohol condition performed worse on the planning, prioritisation, creativity and adaptability executive subscales and also on the time-based and event-based PM tasks. However, alcohol did not impair the selection executive function task or the action-based PM task. Conclusions The results provide further support for the effects of alcohol on executive functioning and PM. In addition, the results suggest that such deficits may be present at relatively modest doses of alcohol and in the absence of a subjective feeling of intoxication Keywords: alcohol; executive functioning; prospective memory; virtual reality; memor

Individual differences in upright and inverted face recognition, simultaneous face matching and object recognition ability throughout the adult lifespan

Objectives: Superior face recognition ability is important for policing and other security roles, and selection of suitable staff for certain operations is essential. Age may be a factor. Our research aims were to enhance theoretical understanding of the relationship between different visual processing tasks, as well as to examine whether the normal mid-thirties peak in face recognition ability would transfer to alternative forensically-relevant face processing tests. Design: Correlational designs examined the relationships between upright and inverted face recognition, simultaneous face matching, object recognition and age in Experiment 1; and face matching CCTV images, passport images and age in Experiment 2. Methods: Worldwide media articles led to participants (n = 250,000) completing a ‘could you be a super-recogniser?’ teaser-test, and in Experiment 1, teaser-test high performers (n = 20,000+; 18-76 years-old) were recruited. In Experiment 2, participants (n = 5,000+) included Metropolitan Police ‘super-recognisers’. Results: Performances across all tests correlated. Face recognition ability peaked at approximately 34-years; face matching high-quality images at 36. Performance subsequently declined. In contrast, the face inversion effect positively correlated with age, while object recognition ability remained consistent throughout the lifespan. No reliable peak age was found for CCTV and passport image matching. Conclusions: The optimum age for high performance (including police officers) on forensic facial examination and recognition tasks appears to be the mid-thirties. Regardless of age, some exceptional participants made few errors on any task, and discussion will focus on these individuals, as well as how high performers in the police positively impact investigations

Chandragupta Maurya: The creation of a national hero in India

We take it for granted that some historical figures become heroes, and others do not. Chandragupta Maurya evolved from obscure ruler to contemporary national icon. The key moment in the making of this Indian hero was a meeting by the banks of the River Indus between Chandragupta and Seleucus, founder of the Seleucid empire and one of Alexander the Great’s generals, in c.305-3 BC. This significant event was a moment of peace-making at the end of conflict. But no reliable account exists in early sources, and it is not even clear which ruler was victorious in battle. This uncertainty enabled British and Indian historians of the nineteenth and twentieth centuries to interpret the sources in radically different ways. With Chandragupta representing India and Seleucus standing in for Britain, British scholars argued that Seleucus defeated Chandragupta, while Indian academics contended the opposite. The writing and reception of history fundamentally influences how we engage with the past, and the evolving colonial and post-colonial relationship between Britain and India is crucial here. In India, the image of Chandragupta as an idealised hero who vanquished the foreign invader has prevailed and found expression in contemporary popular culture. In plays, films, television series, comic books and historical novels, Chandragupta is the powerful and virtuous Hindu ruler par excellence. The path to this elevated standing is charted in this book

Investigating the impact of nicotine on executive functions using a novel virtual reality assessment

Aims Nicotine is known to enhance aspects of cognitive functioning in abstinent smokers but the effects on specific areas of executive functions, and in non-smokers are inconclusive. This may be due in part to the poor sensitivity of tests used to assess executive functions. This study used a new virtual reality assessment of executive functions known as JEF (the Jansari assessment of Executive Functions) to address this issue. Design 2x2 design manipulating group (smokers and never-smokers) and drug (nicotine [4mg for smokers; 2mg for never smokers] vs placebo gum). Setting School of Psychology; University of East LondonParticipants 72 participants (aged 18 to 54). 36 minimally-deprived (2 hr) smokers and 36 never-smokers.Measurements Components of executive function were measured using the virtual reality paradigm JEF, which assesses eight cognitive constructs simultaneously as well as providing an overall performance measure. Results Univariate ANOVAs revealed that nicotine improved overall JEF performance, time-based prospective memory and event-based prospective memory in smokers (p < 0.01) but not in never-smokers. Action-based prospective memory was enhanced in both groups (p < 0.01) and never-smokers out-performed smokers on selective thinking and adaptive thinking (p < 0.01). Conclusions. Overall executive functioning and prospective memory can be enhanced by nicotine gum in abstinent smokers. That smokers were only minimally deprived suggests that JEFis a sensitive measure of executive functioning and that prospective memory is particularly susceptible to disruption by abstinence

Chandragupta Maurya

We take it for granted that some historical figures become heroes, and others do not. Chandragupta Maurya evolved from obscure ruler to contemporary national icon. The key moment in the making of this Indian hero was a meeting by the banks of the River Indus between Chandragupta and Seleucus, founder of the Seleucid empire and one of Alexander the Great’s generals, in c.305-3 BC. This significant event was a moment of peace-making at the end of conflict. But no reliable account exists in early sources, and it is not even clear which ruler was victorious in battle. This uncertainty enabled British and Indian historians of the nineteenth and twentieth centuries to interpret the sources in radically different ways. With Chandragupta representing India and Seleucus standing in for Britain, British scholars argued that Seleucus defeated Chandragupta, while Indian academics contended the opposite. The writing and reception of history fundamentally influences how we engage with the past, and the evolving colonial and post-colonial relationship between Britain and India is crucial here. In India, the image of Chandragupta as an idealised hero who vanquished the foreign invader has prevailed and found expression in contemporary popular culture. In plays, films, television series, comic books and historical novels, Chandragupta is the powerful and virtuous Hindu ruler par excellence. The path to this elevated standing is charted in this book

The Role of PILJ and Its Structural Domains in the Localization and Function of the CHP Chemosensory System in Pseudomonas Aeruginosa

Bacteria detect environmental signals using membrane-bound methyl-accepting chemotaxis proteins (MCPs), which are part of a larger complex of chemosensory proteins. Pseudomonas aeruginosa has four functionally distinct chemosensory protein complexes. The Chp chemosensory system regulates type IV pili mediated twitching motility and intracellular levels of cAMP by modulating the activity of an adenylate cyclase, CyaB. The Chp system is also proposed to be involved in type IV pili mediated directional twitching motility towards phosphatidylethanolamine (PE). PilJ is the only MCP predicted to be associated with the Chp system. In this study we investigated different domains of PilJ in order to decipher their roles in signal transduction and localization of the Chp chemosensory system. Our results show that both the periplasmic and transmembrane domains are involved in signal transduction. A PilJ periplasmic domain mutant (PilJΔ74-273) showed a partial but significant decrease in cAMP levels highlighting the importance of this domain in regulation of this phenotype. However, when sufficient intracellular cAMP is provided, twitching motility occurs in the presence or absence of PE independent of the periplasmic domain. To maintain the inner membrane localization while assaying the role of the transmembrane domains of PilJ, Tsr-PilJ chimeric proteins were used. These fusion proteins showed impaired signal transduction. Through localization studies, we discovered that the role of the PilJ transmembrane domains is not limited to signal transduction. Using fluorescence microscopy, an examination of the intracellular localization of C-terminus truncations of PilJ revealed that the second transmembrane domain plays a role in polar localization of PilJ. This is the first report where the localization of a MCP is impacted by a domain other than the cytoplasmic domain. Determining the internal localization cues for this MCP was important as MCPs are reported to be instrumental in chemosensory cluster formation and localization. Indeed, PilJ is needed for PilI foci formation as demonstrated by fluorescence microscopy studies. Taken together, these studies suggest that the PilJ transmembrane domains are important for both signal transduction and localization. Establishing the importance of PilJ for the potential nucleation of the Chp system paves the path for future work to identify potential partners that would directly or indirectly control the polar localization of PilJ

The impact of developmental dyslexia on workplace cognition: Evidence from a virtual reality environment

The cognitive difficulties associated with dyslexia persist into adulthood but insights into their impact in employment settings are lacking. A virtual office environment was used to assess two areas of cognition frequently called upon in the workplace, executive function and prospective memory. Eight adults with dyslexia and 27 adults without dyslexia were tested on a virtual office task. They read a scenario describing their new role in an office and were given tasks to complete. The group with dyslexia performed worse overall. On the individual performance measures, the group with dyslexia scored lower on the selective-thinking and planning measures of executive function and also performed worse on two of the three prospective memory measures, namely event-based and time-based prospective memory. The findings indicate how dyslexia can affect workplace cognition, identifying areas in which support might be needed and highlighting areas of relative strength which might be harnessed

The impact of developmental dyslexia on workplace cognition: evidence from a virtual reality environment

The cognitive difficulties associated with dyslexia persist into adulthood but insights into their impact in employment settings are lacking. A virtual office environment was used to assess two areas of cognition frequently called upon in the workplace, executive function and prospective memory. Eight adults with dyslexia and 27 adults without dyslexia were tested on a virtual office task. They read a scenario describing their new role in an office and were given tasks to complete. The group with dyslexia performed worse overall. On the individual performance measures, the group with dyslexia scored lower on the selective-thinking and planning measures of executive function and also performed worse on two of the three prospective memory measures, namely event-based and time-based prospective memory. The findings indicate how dyslexia can affect workplace cognition, identifying areas in which support might be needed and highlighting areas of relative strength which might be harnessed