Getting to Common Ground: A Comparison of Ontario, Canada’s Provincial Policy Statement and the Auckland Council Regional Policy Statement with Respect to Indigenous Peoples

Indigenous rights are crucial to contemporary land use planning and policy in settler states. This article comparatively analyzes the manifest and latent content of the 2014 Provincial Policy Statement of Ontario, Canada (PPS) and the 1999 Auckland Council Regional Policy Statement of Aotearoa New Zealand (ACRPS) in order to evaluate their relative capacity to recognize the rights of Indigenous peoples. While the results show that jurisdiction is an impediment to fostering common ground between Indigenous peoples and settler states, the authors conclude that the PPS and the ACRPS serve vital roles in building dialogue and equitable planning outcomes

Getting to Common Ground: A Comparison of Ontario, Canada's Provincial Policy Statement and the Auckland Council Regional Policy Statement with Respect to Indigenous Peoples

Indigenous rights are crucial to contemporary land use planning and policy in settler states. This article comparatively analyzes the manifest and latent content of the 2014 Provincial Policy Statement of Ontario, Canada (PPS) and the 1999 Auckland Council Regional Policy Statement of Aotearoa New Zealand (ACRPS) in order to evaluate their relative capacity to recognize the rights of Indigenous peoples. While the results show that jurisdiction is an impediment to fostering common ground between Indigenous peoples and settler states, the authors conclude that the PPS and the ACRPS serve vital roles in building dialogue and equitable planning outcomes

Long Type I X-ray Bursts and Neutron Star Interior Physics

Superbursts are very energetic Type I X-ray bursts discovered in recent years by long term monitoring of X-ray bursters, believed to be due to unstable ignition of carbon in the deep ocean of the neutron star. A number of "intermediate duration" bursts have also been observed, probably associated with ignition of a thick helium layer. We investigate the sensitivity of these long X-ray bursts to the thermal profile of the neutron star crust and core. We first compare cooling models of superburst lightcurves with observations, and derive constraints on the ignition mass and energy release, and then calculate ignition models for superbursts and pure helium bursts, and compare to observations. The superburst lightcurves and ignition models imply that the carbon mass fraction is approximately 20% or greater in the fuel layer, constraining models of carbon production. However, the most important result is that when Cooper pairing neutrino emission is included in the crust, the temperature is too low to support unstable carbon ignition at the observed column depths. Some additional heating mechanism is required in the accumulating fuel layer to explain the observed properties of superbursts. If Cooper pair emission is less efficient than currently thought, the observed ignition depths for superbursts imply that the crust is a poor conductor, and the core neutrino emission is not more efficient than modified URCA. The observed properties of helium bursts support these conclusions, requiring inefficient crust conductivity and core neutrino emission.Comment: submitted to ApJ (22 pages, 26 figures

Finding Common Ground: A Critical Review of Land Use and Resource Management Policies in Ontario, Canada and their Intersection with First Nations

This article provides an in-depth analysis of selective land use and resource management policies in the Province of Ontario, Canada. It examines their relative capacity to recognize the rights of First Nations and Aboriginal peoples and their treaty rights, as well as their embodiment of past Crown–First Nations relationships. An analytical framework was developed to evaluate the manifest and latent content of 337 provincial texts, including 32 provincial acts, 269 regulatory documents, 16 policy statements, and 5 provincial plans. This comprehensive document analysis classified and assessed how current provincial policies address First Nation issues and identified common trends and areas of improvement. The authors conclude that there is an immediate need for guidance on how provincial authorities can improve policy to make relationship-building a priority to enhance and sustain relationships between First Nations and other jurisdictions

Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity

Abstract Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and systemically across different cancer types. Yet, the exact mechanism(s) of how LPA affects CD8 T cell immunosurveillance during tumor progression remain unknown. We show LPA receptor (LPAR) signaling by CD8 T cells promotes tolerogenic states via metabolic reprogramming and potentiating exhaustive-like differentiation to modulate anti-tumor immunity. We found LPA levels predict response to immunotherapy and Lpar5 signaling promotes cellular states associated with exhausted phenotypes on CD8 T cells. Importantly, we show that Lpar5 regulates CD8 T cell respiration, proton leak, and reactive oxygen species. Together, our findings reveal that LPA serves as a lipid-regulated immune checkpoint by modulating metabolic efficiency through LPAR5 signaling on CD8 T cells. Our study offers key insights into the mechanisms governing adaptive anti-tumor immunity and demonstrates LPA could be exploited as a T cell directed therapy to improve dysfunctional anti-tumor immunity