From digital resources to historical scholarship with the British Library 19th Century Newspaper Collection

It is increasingly acknowledged that the Digital Humanities have placed too much emphasis on data creation and that the major priority should be turning digital sources into contributions to knowledge. While this sounds relatively simple, doing it involves intermediate stages of research that enhance digital sources, develop new methodologies and explore their potential to generate new knowledge from the source. While these stages are familiar in the social sciences they are less so in the humanities. In this paper we explore these stages based on research on the British Library’s Nineteenth Century Newspaper Collection, a corpus of many billion words that has much to offer to our understanding of the nineteenth century but whose size and complexity makes it difficult to work with

Doctor of Philosophy

dissertationZL is a C++-compatible language in which high-level constructs, such as classes, are defined using macros over a C-like core language. This approach is similar in spirit to Scheme and makes many parts of the language easily customizable. For example, since the class construct can be defined using macros, a programmer can have complete control over the memory layout of objects. Using this capability, a programmer can mitigate certain problems in software evolution such as fragile ABIs (Application Binary Interfaces) due to software changes and incompatible ABIs due to compiler changes. ZL's parser and macro expander is similar to that of Scheme. Unlike Scheme, however, ZL must deal with C's richer syntax. Specifically, support for context;-sensitive parsing and multiple syntactic categories (expressions, statements, types, etc.) leads to novel strategies for parsing and macro expansion. In this dissertation we describe ZL's approach to parsing and macros. We demonstrate how to use ZL to avoid problems with ABI instability through techniques such as fixing the size of class instances and controlling the layout of virtual method dispatch tables. We also demonstrate how to avoid problems with ABI incompatibility by implementing another compiler's ABI. Future work includes a more complete implementation of C++ and elevating the approach so that it is driven by a declarative ABI specification language

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials

OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to Prevention Study participants. RESEARCH DESIGN AND METHODS: Two cohorts were analyzed: 1) baseline normoglycemic oral glucose tolerance tests (OGTTs) with an incident dysglycemic OGTT and 2) baseline Index60 <1.00 OGTTs with an incident Index60 ≥1.00 OGTT. Incident dysglycemic OGTTs were divided into those with (DYS/IND+) and without (DYS/IND-) concomitant Index60 ≥1.00. Incident Index60 ≥1.00 OGTTs were divided into those with (IND/DYS+) and without (IND/DYS-) concomitant dysglycemia. RESULTS: The cumulative incidence for type 1 diabetes was greater after IND/DYS- than after DYS/IND- (P < 0.01). Within the normoglycemic cohort, the cumulative incidence of type 1 diabetes was higher after DYS/IND+ than after DYS/IND- (P < 0.001), whereas within the Index60 <1.00 cohort, the cumulative incidence after IND/DYS+ and after IND/DYS- did not differ significantly. Among nonprogressors, type 1 diabetes risk at the last OGTT was greater for IND/DYS- than for DYS/IND- (P < 0.001). Hazard ratios (HRs) of DYS/IND- with age and 30- to 0-min C-peptide were positive (P < 0.001 for both), whereas HRs of type 1 diabetes with these variables were inverse (P < 0.001 for both). In contrast, HRs of IND/DYS- and type 1 diabetes with age and 30- to 0-min C-peptide were consistent (all inverse [P < 0.01 for all]). CONCLUSIONS: The findings suggest that incident dysglycemia without Index60 ≥1.00 is a suboptimal prediagnostic end point for type 1 diabetes. Measures that include both glucose and C-peptide levels, such as Index60 ≥1.00, appear better suited as prediagnostic end points

The effects of single versus twice daily short term heat acclimation on heat strain and 3000 m running performance in hot, humid conditions

Endurance performances are impaired under conditions of elevated heat stress. Short term heat acclimation (STHA) over 4-6 days can evoke rapid adaptation, which mitigate decrements in performance and alleviate heat strain. This study investigated the efficacy of twice daily heat acclimation (TDHA) compared to single session per day heat acclimation (SDHA) and normothermic training, at inducing heat acclimation phenotype and its impact upon running performance in hot, humid conditions.Twenty one, moderately trained males were matched and assigned to three groups; SDHA (mean±SD) (peak oxygen consumption [V˙O2peak] 45.8±6.1 mL kg-1 min-1, body mass 81.3±16.0 kg, stature 182±3 cm), TDHA (46.1±7.0 mL kg-1 min-1, 80.1±11.9 kg, 178±4 cm) or control (CON) (47.1±3.5 mL kg-1 min-1, 78.6±16.7 kg, 178±4 cm). Interventions consisted of 45 min cycling at 50% V˙O2peak, once daily for 4d (SDHA) and twice daily for 2d (TDHA), in 35 °C, 60% relative humidity (RH), and once daily for 4 days (CON) in 21 °C, 40% RH. Participants completed a pre- and post-intervention 5 km treadmill run trial in 30 °C, 60% RH, where the first 2 km were fixed at 40% V˙O2peak and the final 3 km was self-paced.No statistically significant interaction effects occurred within- or between-groups over the 2-4 days intervention. While within-group differences were found in physiological and perceptual measures during the fixed intensity trial post-intervention, they did not statistically differ between-groups. Similarly, TDHA (-36±34 s [+3.5%]) and SDHA (-26±28 s [+2.8%]) groups improved 3 km performances (p=0.35), but did not differ from CON (-6±44 s [+0.6%]).This is the first study to investigate the effects of HA twice daily and compare it with traditional single session per day STHA. These STHA protocols may have the ability to induce partial adaptive responses to heat stress and possibly enhance performance in environmentally challenging conditions, however, future development is warranted to optimise the administration to provide a potent stimuli for heat adaptation in athletic and military personnel within a rapid regime

Adaptability and Social Support: Examining Links with Psychological Wellbeing Among UK Students and Non-students

The purpose of this multi-study article was to investigate the roles of adaptability and social support in predicting a variety of psychological outcomes. Data were collected from Year 12 college students (N = 73; Study 1), university students (N = 102; Study 2), and non-studying members of the general public (N = 141; Study 3). Findings showed that, beyond variance attributable to social support, adaptability made a significant independent contribution to psychological wellbeing (life satisfaction, psychological wellbeing, flourishing, and general affect) and psychological distress across all studies. Beyond the effects of adaptability, social support was found to make a significant independent contribution to most wellbeing outcomes (but not psychological distress in university students). In a multi-group analysis comparing predictors of psychological wellbeing in university students and non-studying adults, where the same outcome measures were used (Study 4; N = 243), it was found that adaptability played a stronger role (relative to social support) for university students, whereas social support played a stronger role for non-studying adults. Finally, (contrary to expectations) there was no evidence of an interaction between adaptability and social support predicting psychological outcomes—adaptability and social support operated as independent main effects. These findings demonstrate the importance of adaptability and social support in uniquely predicting psychological wellbeing in different sample groups. It is argued here that these two factors, should be given greater consideration in discussions of psychological wellbeing, and are relevant to psychological wellbeing at different major developmental life stages

Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter.

Exposure to ambient fine particulate matter (PM2.5) is a major global health concern. Quantitative estimates of attributable mortality are based on disease-specific hazard ratio models that incorporate risk information from multiple PM2.5 sources (outdoor and indoor air pollution from use of solid fuels and secondhand and active smoking), requiring assumptions about equivalent exposure and toxicity. We relax these contentious assumptions by constructing a PM2.5-mortality hazard ratio function based only on cohort studies of outdoor air pollution that covers the global exposure range. We modeled the shape of the association between PM2.5 and nonaccidental mortality using data from 41 cohorts from 16 countries-the Global Exposure Mortality Model (GEMM). We then constructed GEMMs for five specific causes of death examined by the global burden of disease (GBD). The GEMM predicts 8.9 million [95% confidence interval (CI): 7.5-10.3] deaths in 2015, a figure 30% larger than that predicted by the sum of deaths among the five specific causes (6.9; 95% CI: 4.9-8.5) and 120% larger than the risk function used in the GBD (4.0; 95% CI: 3.3-4.8). Differences between the GEMM and GBD risk functions are larger for a 20% reduction in concentrations, with the GEMM predicting 220% higher excess deaths. These results suggest that PM2.5 exposure may be related to additional causes of death than the five considered by the GBD and that incorporation of risk information from other, nonoutdoor, particle sources leads to underestimation of disease burden, especially at higher concentrations

Density, distribution, and habitat of Flammulated Owls in Idaho

From 1990 to 1992 we surveyed for Flammulated Owls (Otus flammeolus) in 3 areas in Idaho: Salmon National Forest (SNF), Payette National Forest and adjacent Hells Canyon National Recreation Area (PNF-HCNRA), and Nez Perce National Forest (NPNF). We also collected and summarized information on all historic and modern records of Flammulated Owls in Idaho. Flammulated Owls were detected on 65% of 68 routes (2–16 km in length) surveyed at densities ranging from 0.04 to 1.25 singing males/40 ha. Owls were detected on survey routes as early as 10 May and as late as 23 July. Mean percent canopy cover estimated at owl locations on the PNF-HCNRA and NPNF study sites ranged from 52% to 64%, while shrub cover ranged from 16% to 21% and ground cover was 39% to 49%. Our surveys and summary of distributional records indicated that Flammulated Owls occur throughout the montane forests of Idaho in old or mature stands of open ponderosa pine (Pinus ponderosa), Douglas-fir (Pseudotsuga menziesii), and stands co-dominated by those 2 species. Fire suppression and timber harvest activity in ponderosa pine forests represent 2 main threats to the species\u27 future security in Idaho. More research on the effects of various silvicultural treatments on Flammulated Owl populations is warranted