Vibration Analysis of Nonlinear Magneto Flexo Electric Mass Sensor Carbon Nanotube Resting on Elastic Substrate

The present paper is dedicated to study the nonlinear ultrasonic waves in a magneto-flexo-thermo elastic armchairsingle-walled carbon nanotube with mass sensors resting on polymer matrix. Here the small-scale effect is captured by Eringen’s nonlocal elasticity theory. After developing the formal solution of the mathematical model consisting of partial differential equations, the frequency equations have been analyzed numerically by using the nonlinear foundations supported by Winkler-Pasternak model. The solution is obtained by ultrasonic wave dispersion relations. Parametric work is carried out to scrutinize the influence of the non local scaling, magneto-flexo-mechanical loadings, foundation parameters, attached mass, various boundary condition and length on the dimensionless frequency of nanotube. It is noticed that the boundary conditions, nonlocal parameter, attached mass and tube geometrical parameters have significant effects on dimensionless frequency of nano tubes

ASSESSMENT OF PSYCHOSOCIAL CONSEQUENCES OF COVID-19 IN DIABETES PATIENTS: A CROSS-SECTIONAL STUDY

Objective: The aim of the study was to assess the psychosocial health, to identify coronavirus disease 2019 (COVID-19) specific concerns in people with diabetes and to analyze the changes in the management of diabetes during the corona crisis. Methods: An online cross-sectional survey was conducted for a period of 6 months among the South Indian diabetes population. A validated questionnaire containing socio-demographics, general health status, the diabetes distress scale 17, and the 3-itemUCLA loneliness scale was sent to 600 people, out of which 226 participants were included in the study based on inclusion and exclusion criteria. Responses were analyzed using univariate and multivariate logistic regressions. Results: Among the participants, females had moderate to high diabetes distress (54.4%). The subjects in the age group of 40–59 years felt lonely and had more diabetes distress. The two major worries among the participants were that “they are labeled as a risk group” and that “they might be overly affected.” Participants with gestational diabetes mellitus (DM), DM duration of 7 months to 1 year, taking both medications (oral antidiabetic medication and insulin), HbA1c level of more than 8%, infected with coronavirus or having someone close to them infected with coronavirus, were more concerned about taking medication daily, and those who changed their meal plan during the corona period had the greatest concerns. Conclusion: People who participated in the survey were more worried about the COVID-19 situation and were very disturbed. Psychosocial consequences of COVID-19 were more prevalent in diabetes patients, including diabetes distress, loneliness, and changes in daily diabetes management

Senescence and cancer : a review of clinical implications of senescence and senotherapies

Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre-malignant to malignant disease. It may also be a key effector mechanism of many types of anticancer therapies, such as chemotherapy, radiotherapy, and endocrine therapies, both directly and via bioactive molecules released by senescent cells that may stimulate an immune response. However, senescence may contribute to reduced patient resilience to cancer therapies and may provide a pathway for disease recurrence after cancer therapy. A new group of drugs, senotherapies, (drugs which interact with senescent cells to interfere with their pro-aging impacts by either selectively destroying senescent cells (senolytic drugs) or inhibiting their function (senostatic drugs)) are under active investigation to determine whether they can enhance the efficacy of cancer therapies and improve resilience to cancer treatments. Senolytic drugs include quercetin, navitoclax, and fisetin and preclinical and early phase clinical data are emerging of their potential role in cancer treatments, although none are yet in routine use clinically. This article provides a review of these issues

Pseudoaneurysm of the Inferior Pancreaticoduodenal Artery Due to Cholecystitis

Inferior pancreaticoduodenal artery pseudoaneurysms and aneurysms are a rare occurrence, comprising of approximately 10% of visceral artery aneurysms and pseudoaneurysms. The cause is normally due to trauma, iatrogenic or pancreatitis. We present a case of a patient re-presenting to hospital following treatment of acute cholecystitis with epigastric pain, dysphagia, pyrexia, nausea, vomiting and an acute kidney injury. Following cholecystostomy, intravenous fluids and conservative treatment for her symptoms, she failed to improve significantly and was found to have a 6 mm pseudoaneurysm of the inferior pancreaticoduodenal artery on day twenty of her admission. She was transferred to a tertiary centre and was treated with an embolisation and recovered well from the procedure

Chilaiditi’s Syndrome—What Every Endoscopist Should Know

Chilaiditi’s syndrome is a rare and often asymptomatic anomaly, typically found as an incidental radiographic sign (gas under the diaphragm) due to hepato-diaphragmatic interposition of the transverse colon. We report a case of Chilaiditi’s syndrome following colonoscopy presenting with severe abdominal pain, dyspnoea and radiograph findings similar to the presence of bowel perforation (appearance of gas under the hemidiaphragm on erect chest radiograph). Computed tomography (CT) evidence of Chilaiditi’s sign prevented unnecessary laparotomy

The Swansea Floating Endoscopic Assistant: A Surgical Handling Aid

Endoscopic sinus surgery is a rapidly advancing area of Otolaryngology. Operations can be lengthy and are often performed by a single surgeon. Repetitive movements can also lead to muscular fatigue. To mitigate against this, we regularly deploy two retractable Flexi™ compact leads, one bigger than the other connected together and suspended from the theatre operating light arm using velcro ties. The leads are then wrapped around the endoscope using a cotton crepe bandage, in a double loop with a reef knot. The larger lead attaches to the focus/zoom adjustment part of the endoscopic camera, and the smaller lead attaches to the scope 20 cm from the tip allowing the scope to float when suspended, with a slight downward tilt towards the patient. The mechanical effect this produces allows an advantageous reduction in the scope’s weight from 404 g un-suspended, to 65 g with the setup described. This subsequently reduces stress on the elbows, shoulders neck and lumbar spine. The Swansea Floating Endoscopic Assistant adheres to basic ergonomic principles and has the potential for application in other areas of Otorhinolaryngology and Skull Base Surgery

Mechanical Duodenal Perforation Due to Complications of Pancreatic Pseudocysts

Pancreatic pseudocysts are a known complication of pancreatitis. There are a multitude of complications which have been described in relation to pancreatic pseudocysts. Perforation of a gastrointestinal hollow viscus is rare but has previously been reported. We report a case of a 72-year-old female with the development of three pancreatic pseudocysts four weeks post gallstone pancreatitis. The patient deteriorated and was found to have a duodenal perforation due to compression forces from the underlying pseudocysts. The patient required emergency surgical intervention and recovered fully following hospital admission

Clozapine-induced stercoral colitis: a surgical perspective

We describe a case of a 46-year-old man with schizophrenia treated with clozapine who presented as an emergency with abdominal pain on the background of a 1 month history of constipation. The initial presenting symptoms were vague and a diagnosis was difficult to establish. Initial CT of the abdomen and pelvis demonstrated only minor abnormalities. He continued to deteriorate until a further CT scan revealed worsening stercoral colitis. He subsequently underwent an emergency total colectomy and ileostomy formation and had a complicated prolonged postoperative recovery. This case highlights the risks that clozapine can have on slowing bowel transit and the dangerous consequences that can occur if not identified early.</jats:p