Authorship, citations, acknowledgments and visibility in social media : symbolic capital in the multifaceted reward system of science

The reward system of science is undergoing significant changes, as traditional indicators compete with initiatives that offer novel means of disseminating and assessing scholarly impact. This paper considers a number of aspects of this reward system, including authorship, citations, acknowledgements, and the growing use of social media platforms by academics, with an eye towards identifying contemporary issues relating to scholarly communication practices, as understood through the perspectives of Bourdieu’s symbolic capital and Merton’s recognition paradigms. This paper posits that, while scientific capital remains the foundation upon which the reward system of science is built, this system is revealing itself to be more and more multifaceted, extremely complex, and facing increasing tension between its traditional means of evaluation and the potential of new indicators in the digital era. The paper presents an extended literature review, as well as recommendations for further considerations and empirical research. A better understanding of the perceptions of academics would be necessary to properly assess the effects of these new indicators on scholarly communication practices and the reward system of science

Multimodal Microscale Imaging of Textured Perovskite-Silicon Tandem Solar Cells.

Halide perovskite/crystalline silicon (c-Si) tandem solar cells promise power conversion efficiencies beyond the limits of single-junction cells. However, the local light-matter interactions of the perovskite material embedded in this pyramidal multijunction configuration, and the effect on device performance, are not well understood. Here, we characterize the microscale optoelectronic properties of the perovskite semiconductor deposited on different c-Si texturing schemes. We find a strong spatial and spectral dependence of the photoluminescence (PL) on the geometrical surface constructs, which dominates the underlying grain-to-grain PL variation found in halide perovskite films. The PL response is dependent upon the texturing design, with larger pyramids inducing distinct PL spectra for valleys and pyramids, an effect which is mitigated with small pyramids. Further, optimized quasi-Fermi level splittings and PL quantum efficiencies occur when the c-Si large pyramids have had a secondary smoothing etch. Our results suggest that a holistic optimization of the texturing is required to maximize light in- and out-coupling of both absorber layers and there is a fine balance between the optimal geometrical configuration and optoelectronic performance that will guide future device designs

Division of Planning Research On-Call Task#8 - Assessment and Prioritization of Culverts for Enhanced Fish Passage

34654Culverts can be an impediment to fish passage, impacting fish populations and spawning of both migratory and non-migratory species. With increased opportunities to invest in both water resources and infrastructure, prioritizing and selecting potential locations for culvert replacement to remove fish barriers is timely. In this project, we engaged with stakeholders in the eastern basin of Lake Erie to discuss and visit both potential and completed culvert replacement project sites; these stakeholders would be strong potential partners for ODOT in the future. The OHIO team also reviewed approved NPS-IS plans for identification of fish passage barriers that may be useful planning and design-ready project sites for ODOT to pursue if funding were available. The OHIO team also developed a method to prioritize and identify potential culvert replacement project locations using a GIS-based analysis. Culverts in target, high quality watersheds on perennial or intermittent streams are identified. Their openness ratio is then calculated; a low openness ratio is poor for fish passage and suggests that the site could be a good candidate. Aerial imagery and LiDAR data are then used to calculate an average slope of the culvert from the streambed upstream to the streambed downstream of the culvert. A high average slope would suggest either a highly sloped culvert or a low to moderate slope culvert with a vertical disconnection on the downstream end; either case would be poor for fish passage. Natural breaks in the data suggested that sites with high slope (>10%) and sites with moderate slope (4-10%) should be field verified as potential project sites

STAT3 can be activated through paracrine signaling in breast epithelial cells

<p>Abstract</p> <p>Background</p> <p>Many cancers, including breast cancer, have been identified with increased levels of phosphorylated or the active form of Signal Transducers and Activators of Transcription 3 (STAT3) protein. However, whether the tumor microenvironment plays a role in this activation is still poorly understood.</p> <p>Methods</p> <p>Conditioned media, which contains soluble factors from MDA-MB-231 and MDA-MB-468 breast cancer cells and breast cancer associated fibroblasts, was added to MCF-10A breast epithelial and MDA-MB-453 breast cancer cells. The stimulation of phosphorylated STAT3 (p-STAT3) levels by conditioned media was assayed by Western blot in the presence or absence of neutralized IL-6 antibody, or a JAK/STAT3 inhibitor, JSI-124. The stimulation of cell proliferation in MCF-10A cells by conditioned media in the presence or absence of JSI-124 was subjected to MTT analysis. IL-6, IL-10, and VEGF levels were determined by ELISA analysis.</p> <p>Results</p> <p>Our results demonstrated that conditioned media from cell lines with constitutively active STAT3 are sufficient to induce p-STAT3 levels in various recipients that do not possess elevated p-STAT3 levels. This signaling occurs through the JAK/STAT3 pathway, leading to STAT3 phosphorylation as early as 30 minutes and is persistent for at least 24 hours. ELISA analysis confirmed a correlation between elevated levels of IL-6 production and p-STAT3. Neutralization of the IL-6 ligand or gp130 was sufficient to block increased levels of p-STAT3 (Y705) in treated cells. Furthermore, soluble factors within the MDA-MB-231 conditioned media were also sufficient to stimulate an increase in IL-6 production from MCF-10A cells.</p> <p>Conclusion</p> <p>These results demonstrate STAT3 phosphorylation in breast epithelial cells can be stimulated by paracrine signaling through soluble factors from both breast cancer cells and breast cancer associated fibroblasts with elevated STAT3 phosphorylation. The induction of STAT3 phosphorylation is through the IL-6/JAK pathway and appears to be associated with cell proliferation. Understanding how IL-6 and other soluble factors may lead to STAT3 activation via the tumor microenvironment will provide new therapeutic regimens for breast carcinomas and other cancers with elevated p-STAT3 levels.</p

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Secure and fast encryption (SAFE) with classical random number generators

Pseudo-random number generators (PRNGs) play an important role in both areas of computer simulation and computer security. Currently, there appears to be a huge divide between the types of PRNGs used in these two areas. For PRNGs in computer security applications, the security concern is extremely important. For PRNGs in computer simulation applications, the properties of high-dimensional equi-distribution, efficiency, long period-length, and portability are important. In recent years, there have been many PRNGs proposed in the area of computer simulation satisfying these nice properties. However, most of them are linear generators, thus sharing the same weakness in predictability. The major aim of this article is to propose a general class of secure generators, called SAFE (secure and fast encryption) generators, by properly mixing two baseline generators with the aforementioned properties to obtain a secure generator that would inherit these nice properties. Specifically, we propose applying a general mutual-shuffling method to certain linear generators, such as the currently most popular MT19937 generator and large-order multiple recursive generators, as well as outputting certain nonlinear transformations of the generated variates to construct secure PRNGS