The masses and density profiles of halos in a LCDM galaxy formation simulation

We investigate the internal structure and density profiles of halos of mass $10^{10}-10^{14}~M_\odot$ in the Evolution and Assembly of Galaxies and their Environment (EAGLE) simulations. These follow the formation of galaxies in a $\Lambda$CDM Universe and include a treatment of the baryon physics thought to be relevant. The EAGLE simulations reproduce the observed present-day galaxy stellar mass function, as well as many other properties of the galaxy population as a function of time. We find significant differences between the masses of halos in the EAGLE simulations and in simulations that follow only the dark matter component. Nevertheless, halos are well described by the Navarro-Frenk-White (NFW) density profile at radii larger than ~5% of the virial radius but, closer to the centre, the presence of stars can produce cuspier profiles. Central enhancements in the total mass profile are most important in halos of mass $10^{12}-10^{13}M_\odot$, where the stellar fraction peaks. Over the radial range where they are well resolved, the resulting galaxy rotation curves are in very good agreement with observational data for galaxies with stellar mass $M_*<5\times10^{10}M_\odot$. We present an empirical fitting function that describes the total mass profiles and show that its parameters are strongly correlated with halo mass

The age of anxiety? It depends where you look: changes in STAI trait anxiety, 1970–2010

Purpose Population-level surveys suggest that anxiety has been increasing in several nations, including the USA and UK. We sought to verify the apparent anxiety increases by looking for systematic changes in mean anxiety questionnaire scores from research publications. Methods We analyzed all available mean State–Trait Anxiety Inventory scores published between 1970 and 2010. We collected 1703 samples, representing more than 205,000 participants from 57 nations. Results Results showed a significant anxiety increase worldwide, but the pattern was less clear in many individual nations. Our analyses suggest that any increase in anxiety in the USA and Canada may be limited to students, anxiety has decreased in the UK, and has remained stable in Australia. Conclusions Although anxiety may have increased worldwide, it might not be increasing as dramatically as previously thought, except in specific populations, such as North American students. Our results seem to contradict survey results from the USA and UK in particular. We do not claim that our results are more reliable than those of large population surveys. However, we do suggest that mental health surveys and other governmental sources of disorder prevalence data may be partially biased by changing attitudes toward mental health: if respondents are more aware and less ashamed of their anxiety, they are more likely to report it to survey takers. Analyses such as ours provide a useful means of double-checking apparent trends in large population surveys

SNP discovery in European lobster (Homarus gammarus) using RAD sequencing

This is the final version. Available from Springer via the DOI in this recordThe European lobster (Homarus gammarus) is a decapod crustacean with a high market value and therefore their fisheries are of major importance to the economies they support. However, over-exploitation has led to profound stock declines in some regions such as Scandinavia and the Mediterranean. To manage this resource sustainably, knowledge of population structure and connectivity is crucial to inform management about dispersal, recruitment, stock identification and food traceability. We used restriction-site associated DNA sequencing to develop novel SNP markers from 55 individuals encompassing much of the species range; SNPs were quality filtered, ranked using F-statistics and the top 96 SNPs adequate for primer design were retained. SNP markers were developed with the aim of maximising the power to detect genetic differentiation between: (i) Atlantic and Mediterranean lobsters and (ii) Atlantic lobsters. This panel of SNPs provides a useful resource for future studies of population genetic structure and assignment in H. gammarus.Natural EnglandNatural Environment Research Council (NERC

The EAGLE simulations of galaxy formation: calibration of subgrid physics and model variations

We present results from thirteen cosmological simulations that explore the parameter space of the "Evolution and Assembly of GaLaxies and their Environments" (EAGLE) simulation project. Four of the simulations follow the evolution of a periodic cube L = 50 cMpc on a side, and each employs a different subgrid model of the energetic feedback associated with star formation. The relevant parameters were adjusted so that the simulations each reproduce the observed galaxy stellar mass function at z = 0.1. Three of the simulations fail to form disc galaxies as extended as observed, and we show analytically that this is a consequence of numerical radiative losses that reduce the efficiency of stellar feedback in high-density gas. Such losses are greatly reduced in the fourth simulation - the EAGLE reference model - by injecting more energy in higher density gas. This model produces galaxies with the observed size distribution, and also reproduces many galaxy scaling relations. In the remaining nine simulations, a single parameter or process of the reference model was varied at a time. We find that the properties of galaxies with stellar mass <~ M* (the "knee" of the galaxy stellar mass function) are largely governed by feedback associated with star formation, while those of more massive galaxies are also controlled by feedback from accretion onto their central black holes. Both processes must be efficient in order to reproduce the observed galaxy population. In general, simulations that have been calibrated to reproduce the low-redshift galaxy stellar mass function will still not form realistic galaxies, but the additional requirement that galaxy sizes be acceptable leads to agreement with a large range of observables

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells. Stimulated 3 prime antisense retroviral coding sequences (SPARCS) are oriented inversely in 3' untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Derepression of these loci results in double-stranded RNA generation following IFN-γ exposure due to bi-directional transcription from the STAT1-activated gene promoter and the 5' long terminal repeat of the antisense ERV. Engagement of MAVS and STING activates downstream TBK1, IRF3, and STAT1 signaling, sustaining a positive feedback loop. SPARCS induction in human tumors is tightly associated with major histocompatibility complex class 1 expression, mesenchymal markers, and downregulation of chromatin modifying enzymes, including EZH2. Analysis of cell lines with high inducible SPARCS expression reveals strong association with an AXL/MET-positive mesenchymal cell state. While SPARCS-high tumors are immune infiltrated, they also exhibit multiple features of an immune-suppressed microenviroment. Together, these data unveil a subclass of ERVs whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy

The APOSTLE simulations: solutions to the Local Group's cosmic puzzles

The Local Group of galaxies offer some of the most discriminating tests of models of cosmic structure formation. For example, observations of the Milky Way (MW) and Andromeda satellite populations appear to be in disagreement with N-body simulations of the "Lambda Cold Dark Matter" ({\Lambda}CDM) model: there are far fewer satellite galaxies than substructures in cold dark matter halos (the "missing satellites" problem); dwarf galaxies seem to avoid the most massive substructures (the "too-big-to-fail" problem); and the brightest satellites appear to orbit their host galaxies on a thin plane (the "planes of satellites" problem). Here we present results from APOSTLE (A Project Of Simulating The Local Environment), a suite of cosmological hydrodynamic simulations of twelve volumes selected to match the kinematics of the Local Group (LG) members. Applying the Eagle code to the LG environment, we find that our simulations match the observed abundance of LG galaxies, including the satellite galaxies of the MW and Andromeda. Due to changes to the structure of halos and the evolution in the LG environment, the simulations reproduce the observed relation between stellar mass and velocity dispersion of individual dwarf spheroidal galaxies without necessitating the formation of cores in their dark matter profiles. Satellite systems form with a range of spatial anisotropies, including one similar to that of the MW, confirming that such a configuration is not unexpected in {\Lambda}CDM. Finally, based on the observed velocity dispersion, size, and stellar mass, we provide new estimates of the maximum circular velocity for the halos of nine MW dwarf spheroidals

Controls on gut phosphatisation : the trilobites from the Weeks Formation Lagerstätte (Cambrian; Utah)

Despite being internal organs, digestive structures are frequently preserved in Cambrian Lagerstätten. However, the reasons for their fossilisation and their biological implications remain to be thoroughly explored. This is particularly true with arthropods--typically the most diverse fossilised organisms in Cambrian ecosystems--where digestive structures represent an as-yet underexploited alternative to appendage morphology for inferences on their biology. Here we describe the phosphatised digestive structures of three trilobite species from the Cambrian Weeks Formation Lagerstätte (Utah). Their exquisite, three-dimensional preservation reveals unique details on trilobite internal anatomy, such as the position of the mouth and the absence of a differentiated crop. In addition, the presence of paired pygidial organs of an unknown function is reported for the first time. This exceptional material enables exploration of the relationships between gut phosphatisation and the biology of organisms. Indeed, soft-tissue preservation is unusual in these fossils as it is restricted to the digestive structures, which indicates that the gut played a central role in its own phosphatisation. We hypothesize that the gut provided a microenvironment where special conditions could develop and harboured a source of phosphorus. The fact that gut phosphatization has almost exclusively been observed in arthropods could be explained by their uncommon ability to store ions (including phosphorous) in their digestive tissues. However, in some specimens from the Weeks Formation, the phosphatisation extends to the entire digestive system, suggesting that trilobites might have had some biological particularities not observed in modern arthropods. We speculate that one of them might have been an increased capacity for ion storage in the gut tissues, related to the moulting of their heavily-mineralised carapace

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1

PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited