Nesiritide: Harmful or Harmless?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90328/1/phco.26.10.1465.pd

Organizing alternatives : examining normative and alternative nonprofit organizing practices /

Includes vita.Homelessness presents a massive organizational problem in the United States, with over 400,000 men, women, and children making use of shelter services each night. In this study, I take a comparative ethnographic approach to study how the use of the organizing Discourses of feminism, paternalism, neoliberalism, and anarchism result in more normative or alternative organizing practices. My project examines the organizing practices at two shelters for homeless women. One shelter is affiliated with an international religious nonprofit organization and self-identified anarchists run the other. Using the communicative constitution of organization (CCO) and institutional logics theories, I propose a theoretical framework for understanding how organizing Discourses are enacted or resisted at the organizational and individual level. My findings highlight how the institutional logics of responsibility, social welfare, and market manifest in different and sometimes paradoxical organizing practices based on the Discourse that is being translated. In this project, I highlight and critique how Discursive translations of institutional logics structure relations of power that impact agency at the individual and organizational level. My project has implications for understanding why the United States organizes around the social problem of homelessness the way it does, and explores alternatives to normative nonprofit organizing practices.Dr. Rebecca J. Meisenbach, Dissertation Supervisor.|Includes vita.Includes bibliographical references (pages 196-214)

A Systematic Review of Online Sex Addiction and Clinical Treatments Using CONSORT Evaluation

Researchers have suggested that the advances of the Internet over the past two decades have gradually eliminated traditional offline methods of obtaining sexual material. Additionally, research on cybersex and/or online sex addictions has increased alongside the development of online technology. The present study extended the findings from Griffiths’ (2012) systematic empirical review of online sex addiction by additionally investigating empirical studies that implemented and/or documented clinical treatments for online sex addiction in adults. A total of nine studies were identified and then each underwent a CONSORT evaluation. The main findings of the present review provide some evidence to suggest that some treatments (both psychological and/or pharmacological) provide positive outcomes among those experiencing difficulties with online sex addiction. Similar to Griffiths’ original review, this study recommends that further research is warranted to establish the efficacy of empirically driven treatments for online sex addiction

Building Information Modelling adoption in the European Union: An overview

Building information modelling (BIM) is one of the most promising recent developments in the Architecture, Engineering, Construction and Operation (AECO) industry. However, its adoption remains a challenge for the AECO industry because it requires a shift to a new way of working, leading to a current discrepancy in the adoption of BIM in the EU. The paper aims at assessing the gaps in the BIM adoption between the 28 EU countries and the barriers related to its implementation. The methodology adopted here is twofold: first, secondary data are given by a systematic literature review, completed with the review of current projects funded by the European Commission, and dealing with fostering the BIM adoption. Second, primary data are provided by a questionnaire survey to classify BIM initiatives regarding policies, the level of adoption and the barriers encountered in the 28 EU countries. In order to grade the heterogeneity of BIM adoption in the EU, we have classified the countries into four categories with different levels of awareness, from early adopters (BIM already mandated) to countries without any plan. The survey has enabled the analysis of twenty barriers to BIM adoption using the four grades in relation to the respondent country. We found barriers that are acknowledged by all countries irrespective of their level of BIM adoption. Other barriers have been already tackled by the early adopters but not by the newcomers who have yet to experience some of these issues. Finally, the assessment of the disparities of BIM adoption within the EU can help the European Commission towards unifying European standard on BIM

A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients

PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Crustal structure of the Arabian Plate: New constraints from the analysis of teleseismic receiver functions

An edited version of this paper was published by Elsevier Science. Copyright 2005, Elsevier Science. See also: http://dx.doi.org/10.1016/j.epsl.2004.12.020; http://atlas.geo.cornell.edu/SaudiArabia/publications/Al-Damegh%202005.htmReceiver functions for numerous teleseismic earthquakes recorded at 23 broadband and mid-band stations in Saudi Arabia and Jordan were analyzed to map crustal thickness within and around the Arabian plate. We used spectral division as well as time domain deconvolution to compute the individual receiver functions and receiver function stacks. The receiver functions were then stacked using the slant stacking approach to estimate Moho depths and Vp/Vs for each station. The errors in the slant stacking were estimated using a bootstrap re-sampling technique. We also employed a grid search waveform modeling technique to estimate the crustal velocity structure for seven stations. A jackknife re-sampling approach was used to estimate errors in the grid search results for three stations. In addition to our results, we have also included published receiver function results from two temporary networks in the Arabian shield and Oman as well as three permanent GSN stations in the region. The average crustal thickness of the late Proterozoic Arabian shield is 39 km. The crust thins to about 23 km along the Red Sea coast and to about 25 km along the margin of the Gulf of Aqaba. In the northern part of the Arabian platform, the crust varies from 33 to 37 km thick. However, the crust is thicker (41?53 km) in the southeastern part of the platform. There is a dramatic change in crustal thickness between the topographic escarpment of the Arabian shield and the shorelines of the Red Sea. We compared our results in the Arabian shield to nine other Proterozoic and Archean shields that include reasonably well determined Moho depths, mostly based on receiver functions. The average crustal thickness for all shields is 39 km, while the average for Proterozoic shields is 40 km, and the average for Archean shields is 38 km. We found the crustal thickness of Proterozoic shields to vary between 33 and 44 km, while Archean shields vary between 32 and 47 km. Overall, we do not observe a significant difference between Proterozoic and Archean crustal thickness. We observed a dramatic change in crustal thickness along the Red Sea margin that occurs over a very short distance. We projected our results over a cross-section extending from the Red Sea ridge to the shield escarpment and contrasted it with a typical Atlantic margin. The transition from oceanic to continental crust of the Red Sea margin occurs over a distance of about 250 km, while the transition along a typical portion of the western Atlantic margin occurs at a distance of about 450 km. This important new observation highlights the abruptness of the breakup of Arabia. We argue that a preexisting zone of weakness coupled with anomalously hot upper mantle could have initiated and expedited the breakup

Family firms in the global economy: toward a deeper understanding of internationalisation determinants, processes and outcomes

Research on the internationalization of family firms has flourished in recent years, yet the mechanisms through which family involvement shapes the determinants, processes, and outcomes of internationalization remain little understood and largely undertheorized. We contribute to research at the intersection of international business and family business by examining the roles of different sources of family firm heterogeneity and the context in shaping the determinants, processes, and outcomes of business internationalization. Drawing on this analysis, we summarize the articles published in this special issue and set out an agenda for further research aimed at advancing a more fine-grained and contextualized understanding of internationalization in family firms

Sex-specific relevance of diabetes to occlusive vascular and other mortality : a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies

Background: Several studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of other risk factors is uncertain. We aimed to determine whether differences in established risk factors, such as blood pressure, BMI, smoking, and cholesterol, explain the higher relative risks of vascular mortality among women than among men. Methods: In our meta-analysis, we obtained individual participant-level data from studies included in the Prospective Studies Collaboration and the Asia Pacific Cohort Studies Collaboration that had obtained baseline information on age, sex, diabetes, total cholesterol, blood pressure, tobacco use, height, and weight. Data on causes of death were obtained from medical death certificates. We used Cox regression models to assess the relevance of diabetes (any type) to occlusive vascular mortality (ischaemic heart disease, ischaemic stroke, or other atherosclerotic deaths) by age, sex, and other major vascular risk factors, and to assess whether the associations of blood pressure, total cholesterol, and body-mass index (BMI) to occlusive vascular mortality are modified by diabetes. Findings: Individual participant-level data were analysed from 980793 adults. During 9 center dot 8 million person-years of follow-up, among participants aged between 35 and 89 years, 19686 (25 center dot 6%) of 76965 deaths were attributed to occlusive vascular disease. After controlling for major vascular risk factors, diabetes roughly doubled occlusive vascular mortality risk among men (death rate ratio [RR] 2 center dot 10, 95% CI 1 center dot 97-2 center dot 24) and tripled risk among women (3 center dot 00, 2 center dot 71-3 center dot 33; x(2) test for heterogeneity p<0 center dot 0001). For both sexes combined, the occlusive vascular death RRs were higher in younger individuals (aged 35-59 years: 2 center dot 60, 2 center dot 30-2 center dot 94) than in older individuals (aged 70-89 years: 2 center dot 01, 1 center dot 85-2 center dot 19; p=0 center dot 0001 for trend across age groups), and, across age groups, the death RRs were higher among women than among men. Therefore, women aged 35-59 years had the highest death RR across all age and sex groups (5 center dot 55, 4 center dot 15-7 center dot 44). However, since underlying confounder-adjusted occlusive vascular mortality rates at any age were higher in men than in women, the adjusted absolute excess occlusive vascular mortality associated with diabetes was similar for men and women. At ages 35-59 years, the excess absolute risk was 0 center dot 05% (95% CI 0 center dot 03-0 center dot 07) per year in women compared with 0 center dot 08% (0 center dot 05-0 center dot 10) per year in men; the corresponding excess at ages 70-89 years was 1 center dot 08% (0 center dot 84-1 center dot 3 2) per year in women and 0 center dot 91% (0 center dot 77-1 center dot 05) per year in men. Total cholesterol, blood pressure, and BMI each showed continuous log-linear associations with occlusive vascular mortality that were similar among individuals with and without diabetes across both sexes. Interpretation: Independent of other major vascular risk factors, diabetes substantially increased vascular risk in both men and women. Lifestyle changes to reduce smoking and obesity and use of cost-effective drugs that target major vascular risks (eg, statins and antihypertensive drugs) are important in both men and women with diabetes, but might not reduce the relative excess risk of occlusive vascular disease in women with diabetes, which remains unexplained

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome

The well described conventional antigen processing pathway is accountable for most peptides that end up in MHC class I molecules at the cell surface. These peptides experienced liberation by the proteasome and transport by the peptide transporter TAP. However, there are multiple roads that lead to Rome, illustrated by the increasing number of alternative processing pathways that have been reported during last years. Interestingly, TAP-deficient individuals do not succumb to viral infections, suggesting that CD8 T cell immunity is sufficiently supported by alternative TAP-independent processing pathways. To date, a diversity of viral and endogenous TAP-independent peptides have been identified in the grooves of different MCH class I alleles. Some of these peptides are not displayed by normal TAP-positive cells and we therefore called them TEIPP, for ‘T-cell epitopes associated with impaired peptide processing’. TEIPPs are hidden self-antigens, are derived from normal housekeeping proteins and are processed via unconventional processing pathways. Per definition, TEIPPs are presented via TAP-independent pathways, but recent data suggest that part of this repertoire still depend on proteasome and metalloprotease activity. An exception is the C-terminal peptide of the ER-membrane spanning ceramide synthase Trh4 that is surprisingly liberated by the signal peptide peptidase (SPP), the proteolytic enzyme involved in cleaving leader sequences. The intramembrane cleaving SPP is thereby an important contributor of TAP-independent peptides. Its family members, like the Alzheimer’s related presenilins, might as well, according to our preliminary data. Finally, alternative peptide routing is an emerging field and includes processes like the unfolded protein response, the ER-associated degradation and autophagy-associated vesicular pathways. These data convince us that there is a world to be discovered in the field of unconventional antigen processing