¿El empresario nace o se hace? Educación y empresarialidad en la España Contemporánea

This article studies the possible effect that education may have upon entrepreneurial success. It uses two data bases, one for Spanish, the other for English entrepreneurs. By means of statistical and econometric analysis, we examine the effects on entrepreneurial behaviour of a series of variables, several relating to education. We compare the Spanish with the English sample. The main conclusions are: education indeed has a considerable bearing upon entrepreneurial success; this bearing is much more evident in the English than in the Spanish samples; both educational systems are quite different; and, lastly, family income seems to have little effect either on entrepreneurial success or on the studies of future entrepreneurs.Este artículo trata de investigar, entre los factores que determinan el comportamiento empresarial, el posible efecto de la educación. A partir de dos bases de datos, una de empresarios españoles y otra de ingleses, y por medio de análisis estadísticos y econométricos, estudia los efectos de la educación y otras variables sobre algunos parámetros de éxito empresarial. El análisis compara el caso español con el inglés. Las principales conclusiones son: la educación tiene un papel determinante en la ejecutoria del empresario; esta influencia es mucho más clara en el caso inglés que en el español, siendo muy diferentes sus estructuras educativas; y, por último, la renta familiar no parece determinante ni de la ejecutoria empresarial ni tampoco del nivel de estudios alcanzado.Los autores quieren agradecer la ayuda intelectual y moral de sus compañeros del equipo del proyecto Detesemp-CM (S2007/HUM-0433), patrocinado por la Comunidad de Madri

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

A Spectrum of an Extrasolar Planet

Of the over 200 known extrasolar planets, 14 exhibit transits in front of their parent stars as seen from Earth. Spectroscopic observations of the transiting planets can probe the physical conditions of their atmospheres. One such technique can be used to derive the planetary spectrum by subtracting the stellar spectrum measured during eclipse (planet hidden behind star) from the combined-light spectrum measured outside eclipse (star + planet). Although several attempts have been made from Earth-based observatories, no spectrum has yet been measured for any of the established extrasolar planets. Here we report a measurement of the infrared spectrum (7.5--13.2 micron) of the transiting extrasolar planet HD209458b. Our observations reveal a hot thermal continuum for the planetary spectrum, with approximately constant ratio to the stellar flux over this wavelength range. Superposed on this continuum is a broad emission peak centered near 9.65 micron that we attribute to emission by silicate clouds. We also find a narrow, unidentified emission feature at 7.78 micron. Models of these ``hot Jupiter'' planets predict a flux peak near 10 micron, where thermal emission from the deep atmosphere emerges relatively unimpeded by water absorption, but models dominated by water fit the observed spectrum poorly

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Cricket community acoustics: a new tool to detect invasive ants.

Relatório curricular de mestrado (Análises Clínicas), apresentado á Faculdade de Farmácia da Universidade de CoimbraO presente trabalho apresenta as atividades desenvolvidas no âmbito do estágio curricular, inserido no Mestrado em Análises Clínicas da Faculdade de Farmácia da Universidade de Coimbra. O referido estágio realizou-se no Laboratório de Análises Clínicas do Centro de Saúde Militar de Coimbra, de Dezembro de 2014 a Maio de 2015, sob a orientação do Dr. Mário João Roque. Neste relatório serão apresentados os métodos usados na execução das análises, a sua importância clínica, a organização diária e o sistema de gestão de qualidade implementado no laboratório. Serão desenvolvidos de modo mais detalhado os sectores de hematologia e bioquímicaThe present work exposes the activities developed in the internship within the context, of the Master´s degree of Clinical Analysis, of the Faculty of Pharmacy, University of Coimbra. The training was performed at the Clinical Analysis Laboratory of Centro de Saúde Militar of Coimbra, from December to May 2015, under the supervision of Dr. Mario João Roque. In this report will be present the methods used in the execution of laboratorial assays, the clinical interest of the laboratory test, the daily organization and quality management system implemented in the laboratory. This report presents a more detailed description of the hematology and biochemistry sector

Preface of MEPDaW 2020: Managing the evolution and preservation of the data web

The MEPDaW workshop series targets one of the emerging and fundamental problems of the Web, specifically the management and preservation of evolving knowledge graphs. During the past six years, the workshop series has been gathering a community of researchers and practitioners around these challenges. To date, the series has successfully published more than 30 articles allowing more than 50 individual authors to present and share their ideas. This 6th edition, virtually co-located with the International Semantic Web Conference (ISWC 2020), gathered the community around nine research publications and one invited keynote presentation. The event took place online on the 1st of November, 2020

How many human proteoforms are there?

Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype