MOST Space Telescope Photometry of the 2010 January Transit of Extrasolar Planet HD80606b

We present observations of the full January 2010 transit of HD80606b from the Canadian microsatellite, Microvariability and Oscillations of Stars (MOST). By employing a space-based telescope, we monitor the entire transit thus limiting systematic errors that result from ground observations. We determine measurements for the planetary radius (R_{p}=0.987\pm0.061R_{Jup}) and inclination (i=89.283^{o}\pm0.024) by constraining our fits with the observed parameters of different groups. Our measured mid-transit time of 2455210.6449\pm0.0034 HJD is consistant with the 2010 Spitzer results and is 20 minutes earlier than predicted by groups who observed the June 2009 transit.Comment: 3 figure

Peer victimization and substance use: Understanding the indirect effect of depressive symptomatology across gender

OBJECTIVE: Peer victimization in school is common, with emerging literature suggesting that it may also increase risk for substance abuse. Yet, little is known about the underlying mechanisms within this risk pathway. The objective of this study is to use a prospective 3-wave design to examine the mediating role of depressive symptomatology on the relationship between peer victimization and substance use, as well as examine if the pathway varies based on gender. METHOD: 801 youth between 6th and 12th grade completed surveys across three years, which included measures on school peer victimization, depression symptomatology and substance use. Models tested the mediational pathway between victimization, depressive symptoms, and substance use. Models were stratified by gender. RESULTS: Controlling for grade and the effect of each variable across waves, a significant indirect effect of peer victimization on substance use through depressive symptoms was found for females, with a non-significant indirect effect for males. CONCLUSION: Results suggest that female youth who are victimized by peers engage in substance use behaviors, at least in part, due to increases in depressive symptoms. Given its effect on depression, female victims may therefore benefit from coping skills training that targets emotion regulation and distress tolerance skills in order to combat increased risk for substance use behaviors as a coping response to their victimization. Further research is warranted to better understand the risk pathway for male youth who also experience peer victimization

Gender And Career Success in Public Accounting

Public accountants, students, and others evaluated career success and the effect of specific activities on career success. The results suggest that gender bias is not pervasive in public accounting, at least with respect to overall assessments of success, but male and female accountants do appear to weight differently various activities that contribute to career success. This may explain, in part, why women hold fewer public accounting leadership positions than men even though women appear to have an advantage over men when they begin their careers

The Effectiveness of Cognitive Behavioral Therapy on Management of Symptoms in Rheumatoid Arthritis Patients

Objectives: To carry out a systematic review of literature examining the effectiveness of cognitive behavioral therapy (CBT) alongside pharmacological treatment of rheumatoid arthritis (RA) symptoms compared to pharmacological treatments (standard care) without CBT. Methods: The Iowa Model of Evidence-Based Practice to Promote Quality Care was used as the theoretical framework for this review of literature. Databases utilized: CINAHL, OneSearch, PubMed, and MedLine. The inclusion criteria for this search were: CBT as an intervention, articles published within 2006-2016, and English full text articles. Exclusion criteria were: participants less than 18 years of age, interventions other than CBT, or any other type of arthritis that was not RA. Out of 96 articles found, 10 were included in this review of literature. Results: Out of the 10 articles chosen for this review, included were: 51 randomized controlled trials, 31 studies, 47 transcripts, and 5,345 participants. In seven articles pain and depression symptoms showed improvement with CBT; six articles showed fatigue and physical activity improved. However, only one demonstrated evidence that CBT improved anxiety symptoms. Conclusion: This review of literature focused on how CBT in combination with standard care for RA (pharmacological therapy) would affect symptom management. Evidence suggests that CBT is an effective treatment intervention alongside pharmacological therapy on management of symptoms in RA. Research evaluating the long-term effects, overall quality of life, and maintenance therapy related to CBT should be explored further

Hydrogen‐Borrowing‐Based Methods for the Construction of Quaternary Stereocentres

Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α‐quaternary ketones via a tandem acceptorless dehydrogenation‐cyclisation cascade. This new application of the methodology results in the formation of five‐ and six‐membered carbocycles with a high degree of diastereoselectivity. Interestingly, benzylic alcohol substrates behaved anomalously and eliminated sulfinate in situ to give a set of rearranged α‐quaternary ketone products

Interprofessional Education in the Context of Feeding and Swallowing

INTRODUCTION Speech-language pathologists, occupational therapists, and registered dietitian nutritionists are intricately involved in the management of feeding and swallowing disorders. An interprofessional education (IPE) event was held with graduate level students from these disciplines as an opportunity to practice professional collaboration around the topic of food intake. The purpose of this study was to assess the change in these healthcare students’ perceptions of interprofessional collaboration following the interactive IPE event to determine the benefits of incorporating IPE into the curriculum. METHODS 128 students, across three healthcare disciplines (speech-language pathology, occupational therapy, and dietetics), participated in an online survey before and after the IPE event regarding their attitudes toward interprofessional healthcare teams. The IPE event focused on feeding and swallowing, included lectures from professors representing each discipline, and an interactive lab portion highlighting the role each discipline plays in the treatment of feeding and swallowing disorders. RESULTS Overall, students’ perceptions of interprofessional collaboration across all three departments significantly increased after the IPE event suggesting that students considered the IPE event to be a beneficial experience. Considerable improvement was noted on questions regarding the individual role and others’ roles in an interdisciplinary setting. CONCLUSIONS These findings suggest that formal IPE events improve students’ perceptions and understanding of how a collaborative team works together using each discipline’s scope of practice

Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Purpose: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro—using the plaque reduction assay—a highly potent 1-polymer conjugate, and subsequently test its antiviral efficacy in vivo. Methods: By examining the structure-activity relationship of 1-polymer conjugates in the plaque assay, we have determined that the most potent inhibitor against several representative influenza virus strains has a neutral high-molecular-weight backbone and a short alkyl linker. We have examined this optimal polymeric inhibitor for efficacy and immunogenicity in the mouse and ferret models of infection. Results: 1 attached to poly-L-glutamine is an effective therapeutic for established influenza infection in ferrets, reducing viral titers up to 30-fold for 6 days. There is also up to a 190-fold reduction in viral load when the drug is used as a combined prophylactic/therapeutic in mice. Additionally, we see no evidence that the drug conjugate stimulates an immune response in mice upon repeat administration. Conclusions: 1 attached to a neutral high-molecular-weight backbone through a short alkyl linker drastically reduced both in vitro and in vivo titers compared to those observed with 1 itself. Thus, further development of this polymeric zanamivir for the mitigation of influenza infection seems warranted.National Institutes of Health (U.S.) (Grant U01-AI074443

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukemia

Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL) cases with a distinct gene expression profile, the most common of which is MEF2DBCL9. Examination of an extended cohort of 1,164 B-ALL cases identified 30 cases with MEF2D rearrangements, which include an additional fusion partner, FOXJ2; thus, MEF2D-rearranged cases comprise 5.3% of cases lacking recurring alterations. MEF2D-rearranged ALL is characterized by a distinct immunophenotype, DNA copy number alterations at the rearrangement sites, older diagnosis age and poor outcome. The rearrangements result in enhanced MEF2D transcriptional activity, lymphoid transformation, activation of HDAC9 expression and sensitive to histone deacetylase inhibitor treatment. Thus, MEF2D-rearranged ALL represents a distinct form of high-risk leukaemia, for which new therapeutic approaches should be considered.This work was supported in part by the American Lebanese Syrian Associated Charities of St. Jude Children’s Research Hospital; by a Stand Up to Cancer Innovative Research Grant and St. Baldrick’s Foundation Scholar Award (to C.G.M.); by a St. Baldrick’s Consortium Award (S.P.H.), by a Leukemia and Lymphoma Society Specialized Center of Research grant (S.P.H. and C.G.M.), by a Lady Tata Memorial Trust Award (I.I.), by a Leukemia and Lymphoma Society Special Fellow Award and Alex’s Lemonade Stand Foundation Young Investigator Awards (K.R.), by an Alex’s Lemonade Stand Foundation Award (M.L.) and by National Cancer Institute Grants CA21765 (St Jude Cancer Center Support Grant), U01 CA157937 (C.L.W. and S.P.H.), U24 CA114737 (to Dr Gastier-Foster), NCI Contract HHSN261200800001E (to Dr Gastier-Foster), U10 CA180820 (ECOG-ACRIN Operations) and CA180827 (E.P.); U10 CA180861 (C.D.B. and G.M.); U24 CA196171 (The Alliance NCTN Biorepository and Biospecimen Resource); CA145707 (C.L.W. and C.G.M.); and grants to the COG: U10 CA98543 (Chair’s grant and supplement to support the COG ALL TARGET project), U10 CA98413 (Statistical Center) and U24 CA114766 (Specimen Banking). This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract Number HHSN261200800001E

Peer Victimization, Mood Symptoms, and Alcohol Use: Examining Effects Among Diverse High School Youth

Peer victimization is associated with alcohol use among adolescents. However, few studies have examined the mediating role of depression and anxiety, or differences by race. The current study examined the prospective relationship of peer victimization, depressive and anxiety symptoms, and alcohol use across two timeframes: 9th to 11th grade and 10th to 12th grade among African American and White youth. 2,202 high school youth (57.6% female) who identified as either African American (n=342, 15.2%) or White (n=1860, 82.6%) provided data on study variables. Path analysis among the overall sample indicated that anxiety symptoms was a significant mediator for both timeframes, with depressive symptoms mediating the pathway during the 10th to 12th grade timeframe. The findings were most consistent among White youth, with no significant indirect effects observed for African American youth. Thus, addressing depressive and anxiety symptoms may be effective targets to decrease alcohol use risk as a result of peer victimization among White youth. However, further research is needed to better understand risk models for peer victimization exposure on substance use outcomes among racial/ethnic minority youth