Lutein Protects against Methotrexate-Induced and Reactive Oxygen Species-Mediated Apoptotic Cell Injury of IEC-6 Cells

Purpose High-dose chemotherapy using methotrexate (MTX) frequently induces side effects such as mucositis that leads to intestinal damage and diarrhea. Several natural compounds have been demonstrated of their effectiveness in protecting intestinal epithelial cells from these adverse effects. In this paper, we investigated the protection mechanism of lutein against MTX-induced damage in IEC-6 cells originating from the rat jejunum crypt. Methods: The cell viability, induced-apoptosis, reactive oxygen species (ROS) generation, and mitochondrial membrane potential in IEC-6 cells under MTX treatment were examined in the presence or absence of lutein. Expression level of Bcl2, Bad and ROS scavenging enzymes (including SOD, catalase and Prdx1) were detected by quantitative RT-PCR. Results: The cell viability of IEC-6 cells exposed to MTX was decreased in a dose- and time-dependent manner. MTX induces mitochondrial membrane potential loss, ROS generation and caspase 3 activation in IEC-6 cells. The cytotoxicity of MTX was reduced in IEC-6 cells by the 24 h pre-treatment of lutein. We found that pre-treatment of lutein significantly reduces MTX-induced ROS and apoptosis. The expression of SOD was up-regulated by the pre-treatment of lutein in the MTX-treated IEC-6 cells. These results indicated that lutein can protect IEC-6 cells from the chemo-drugs induced damage through increasing ROS scavenging ability. Conclusion: The MTX-induced apoptosis of IEC-6 cells was shown to be repressed by the pre-treatment of lutein, which may represent a promising adjunct to conventional chemotherapy for preventing intestinal damages

Efficient metal halide perovskite light-emitting diodes with significantly improved light extraction on nanophotonic substrates.

Metal halide perovskite has emerged as a promising material for light-emitting diodes. In the past, the performance of devices has been improved mainly by optimizing the active and charge injection layers. However, the large refractive index difference among different materials limits the overall light extraction. Herein, we fabricate efficient methylammonium lead bromide light-emitting diodes on nanophotonic substrates with an optimal device external quantum efficiency of 17.5% which is around twice of the record for the planar device based on this material system. Furthermore, optical modelling shows that a high light extraction efficiency of 73.6% can be achieved as a result of a two-step light extraction process involving nanodome light couplers and nanowire optical antennas on the nanophotonic substrate. These results suggest that utilization of nanophotonic structures can be an effective approach to achieve high performance perovskite light-emitting diodes

Eclipsing Binaries From the CSTAR Project at Dome A, Antarctica

The Chinese Small Telescope ARray (CSTAR) has observed an area around the Celestial South Pole at Dome A since 2008. About $20,000$ light curves in the i band were obtained lasting from March to July, 2008. The photometric precision achieves about 4 mmag at i = 7.5 and 20 mmag at i = 12 within a 30 s exposure time. These light curves are analyzed using Lomb--Scargle, Phase Dispersion Minimization, and Box Least Squares methods to search for periodic signals. False positives may appear as a variable signature caused by contaminating stars and the observation mode of CSTAR. Therefore the period and position of each variable candidate are checked to eliminate false positives. Eclipsing binaries are removed by visual inspection, frequency spectrum analysis and locally linear embedding technique. We identify 53 eclipsing binaries in the field of view of CSTAR, containing 24 detached binaries, 8 semi-detached binaries, 18 contact binaries, and 3 ellipsoidal variables. To derive the parameters of these binaries, we use the Eclipsing Binaries via Artificial Intelligence (EBAI) method. The primary and the secondary eclipse timing variations (ETVs) for semi-detached and contact systems are analyzed. Correlated primary and secondary ETVs confirmed by false alarm tests may indicate an unseen perturbing companion. Through ETV analysis, we identify two triple systems (CSTAR J084612.64-883342.9 and CSTAR J220502.55-895206.7). The orbital parameters of the third body in CSTAR J220502.55-895206.7 are derived using a simple dynamical model.Comment: 41 pages, 12 figures; published online in ApJ

Relationship between eruptions of active-region filaments and associated flares and CMEs

To better understand the dynamical process of active-region filament eruptions and associated flares and CMEs, we carried out a statistical study of 120 events observed by BBSO, TRACE, and t(SOHO/EIT) from 1998 to 2007 and combined filament observations with the NOAA's flare reports, MDI magnetograms, and LASCO data, to investigate the relationship between active-region filament eruptions and other solar activities. We found that 115 out of 120 filament eruptions are associated with flares. 56 out of 105 filament eruptions are found to be associated with CMEs except for 15 events without corresponding LASCO data. We note the limitation of coronagraphs duo to geometry or sensitivity, leading to many smaller CMEs that are Earth-directed or well out of the plane of sky not being detected by near-Earth spacecraft. Excluding those without corresponding LASCO data, the CME association rate of active-region filament eruptions clearly increases with X-ray flare class from about 32% for C-class flares to 100% for X-class flares. The eruptions of active-region filaments associated with Halo CMEs are often accompanied by large flares. About 92% events associated with X-class flare are associated with Halo CMEs. Such a result is due to that the Earth-directed CMEs detected as Halo CMEs are often the larger CMEs and many of the smaller ones are not detected because of the geometry and low intensity. The average speed of the associated CMEs of filament eruptions increases with X-ray flare size from 563.7 km/s for C-class flares to 1506.6 km/s for X-class flares. Moreover, the magnetic emergence and cancellation play an important role in triggering filament eruptions. These findings may be instructive to not only in respect to the modeling of active-region filament eruptions but also in predicting flares and CMEs.Comment: 19 Pages, 7 figures, Accepted for publication in MNRA

Processing of ultrafine-size particulate metal matrix composites by advanced shear technology

Copyright @ 2009 ASM International. This paper was published in Metallurgical & Materials Transactions A 40A(3) and is made available as an electronic reprint with the permission of ASM International. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplications of any material in this paper for a fee or for commercial purposes, or modification of the content of this paper are prohibited.Lack of efficient mixing technology to achieve a uniform distribution of fine-size reinforcement within the matrix and the high cost of producing components have hindered the widespread adaptation of particulate metal matrix composites (PMMCs) for engineering applications. A new rheo-processing method, the melt-conditioning high-pressure die-cast (MC-HPDC) process, has been developed for manufacturing near-net-shape components of high integrity. The MC-HPDC process adapts the well-established high shear dispersive mixing action of a twin-screw mechanism to the task of overcoming the cohesive force of the agglomerates under a high shear rate and high intensity of turbulence. This is followed by direct shaping of the slurry into near-net-shape components using an existing cold-chamber die-casting process. The results indicate that the MC-HPDC samples have a uniform distribution of ultrafine-sized SiC particles throughout the entire sample in the as-cast condition. Compared to those produced by conventional high-pressure die casting (HPDC), MC-HPDC samples have a much improved tensile strength and ductility.EP-SR

The proper class generated by weak supplements

We show that, for hereditary rings, the smallest proper classes containing respectively the classes of short exact sequences determined by small submodules, submodules that have supplements and weak supplement submodules coincide. Moreover, we show that this class can be obtained as a natural extension of the class determined by small submodules. We also study injective, projective, coinjective and coprojective objects of this class. We prove that it is coinjectively generated and its global dimension is at most 1. Finally, we describe this class for Dedekind domains in terms of supplement submodules.TUBITAK (107T709

X-Oscar: A Progressive Framework for High-quality Text-guided 3D Animatable Avatar Generation

Recent advancements in automatic 3D avatar generation guided by text have made significant progress. However, existing methods have limitations such as oversaturation and low-quality output. To address these challenges, we propose X-Oscar, a progressive framework for generating high-quality animatable avatars from text prompts. It follows a sequential Geometry->Texture->Animation paradigm, simplifying optimization through step-by-step generation. To tackle oversaturation, we introduce Adaptive Variational Parameter (AVP), representing avatars as an adaptive distribution during training. Additionally, we present Avatar-aware Score Distillation Sampling (ASDS), a novel technique that incorporates avatar-aware noise into rendered images for improved generation quality during optimization. Extensive evaluations confirm the superiority of X-Oscar over existing text-to-3D and text-to-avatar approaches. Our anonymous project page: https://xmu-xiaoma666.github.io/Projects/X-Oscar/.Comment: ICML202

Indosinian high-strain deformation for the Yunkaidashan tectonic belt, south China : Kinematics and 40Ar/39Ar geochronological constraints

Structural and 40Ar/39Ar data from the Yunkaidashan Belt document kinematic and tectonothermal characteristics of early Mesozoic Indosinian orogenesis in the southern part of the South China Block. The Yunkaidashan Belt is tectonically divided from east to west into the Wuchuang-Sihui shear zone, Xinyi-Gaozhou block, and the Fengshan-Qinxi shear zone. Indosinian structural elements ascribed to the Indosinian orogeny include D2 and D3 deformation. The early D2 phase is characterized by folding and thrusting with associated foliation and lineation development, related to NW-SE transpression under amphibolite- to greenschist-facies conditions. This event is heterogeneously overprinted by D3 deformation characterized by a gentle-dipping S-3 foliation, subhorizontally to shallowly plunging L3 lineation, some reactived-D2 folds and low-angle normal faults. The D3 fabrics suggest a sinistral transtensional regime under greenschist-facies metamorphism. The timing of the D2 and D3 events have been constrained to the early to middle Triassic (similar to 248-220 Ma) and late Triassic (similar to 220-200 Ma) respectively on the basis of 40Ar/39Ar geochronology and regional geological relations. The change from oblique thrusting (D2) to sinistral transtension (D3) may reflect oblique convergence and crustal thickening followed by relaxation of the overthickened crust. In combination with the regional relations from Xuefengshan to Yunkaidashan and on to Wuyishan, the early phase of the Indosinian orogeny constituted a large-scale positive flower structure and is related to the intracontinental convergence during the assembly of Pangea in which the less competent South China Orogen was squeezed between the more competent North China and Indosinian Blocks.Peer reviewe