A General Pattern-Based Design Optimization for Asymmetric Spoke-Type Interior PM Machines

A novel asymmetric spoke-type interior permanent magnet (AS-IPM) machine is proposed in this paper. It utilizes the magnetic-field-shifting (MFS) effect to improve the torque performance, which achieves a high utilization ratio of both permanent magnet (PM) torque and reluctance torque. In addition, a general pattern of rotor topologies is proposed to represent all possible machine structures. Various rotor structures can be obtained by changing the design parameters of the general pattern. A non-dominated sorting genetic algorithm II (NSGA-II) is adopted to automatically search for optimal rotor configurations. With the aid of the optimization program, an asymmetric spoke-type rotor structure with improved performance is obtained. To showcase the advantages of the proposed machine, the electromagnetic performance is compared between a conventional spoke-type interior permanent magnet (S-IPM) machine and a proposed AS-IPM machine. The finite-element simulation results show that the optimal design of the AS-IPM performs a 7.7% higher output torque ripple due to the MFS effect while the total PM volume remains the same. Meanwhile, the torque ripple of the proposed structure is significantly reduced by 82.1%

Therapeutic potential of microRNA-506 in cancer treatment: mechanisms and therapeutic implications

Cancer is a complex and highly lethal disease marked by unchecked cell proliferation, aggressive behavior, and a strong tendency to metastasize. Despite significant advancements in cancer diagnosis and treatment, challenges such as early detection difficulties, drug resistance, and adverse effects of radiotherapy or chemotherapy continue to threaten patient survival. MicroRNAs (miRNAs) have emerged as critical regulators in cancer biology, with miR-506 being extensively studied and recognized for its tumor-suppressive effects across multiple cancer types. This review examines the regulatory mechanisms of miR-506 in common cancers, focusing on its role in the competing endogenous RNA (ceRNA) network and its effects on cancer cell proliferation, apoptosis, and migration. We also discuss the potential of miR-506 as a therapeutic target and its role in overcoming drug resistance in cancer treatment. Overall, these insights underscore the therapeutic potential of miR-506 and its promise in developing novel cancer therapies

The Stability of Set-Valued Differential Equations with Different Initial Time in the Sense of Fractional-like Hukuhara Derivatives

This paper investigates set-valued differential equations with fractional-like Hukuhara derivatives. Firstly, a novel comparison principle is given by introducing the upper quasi-monotone increasing functions. Then, the stability criteria of Lipschitz stability and practical stability of such equations with different initial time are obtained via the new comparison principle and vector Lyapunov functions

The Stability of Set-Valued Differential Equations with Different Initial Time in the Sense of Fractional-like Hukuhara Derivatives

This paper investigates set-valued differential equations with fractional-like Hukuhara derivatives. Firstly, a novel comparison principle is given by introducing the upper quasi-monotone increasing functions. Then, the stability criteria of Lipschitz stability and practical stability of such equations with different initial time are obtained via the new comparison principle and vector Lyapunov functions.</jats:p

Comparative Analysis of Consequent-Pole Flux-Switching Machines with Different Permanent Magnet Arrangements for Outer-Rotor In-Wheel Direct-Drive Applications

Recently, the interest in consequent-pole flux-switching permanent magnet (CP-FSPM) machines has been increasing because of the flux-focusing PM arrangements and the removal of the flux-barrier effect. A simple and rigid outer-rotor salient pole rotor structure can be adopted in CP-FSPM machines, making them applicable for in-wheel direct-drive applications. In this study, three CP-FSPM machines with II-shaped (II-PM), V-shaped (V-PM), and straight U-shaped PM (SU-PM) arrays are analyzed and compared. Moreover, a CP-FSPM machine with inclined U-shaped PM (IU-PM) arrays is proposed to improve the flux-focusing effect and stator slot utilization. The working principles of CP-FSPM machines are analyzed by adopting a semi-analytical model. Combining the finite element analysis (FEA) results of air gap flux density and the analytical model of phase back electromotive force (EMF), the contributions of multiple working harmonics to the back EMF are quantitatively analyzed. Additionally, 6/16 and 6/17 CP-FSPM machines with different PM arrangements are globally optimized. Both the no-load and on-load performance of the optimized machines are included in the performance comparison. The results illustrate that the 6/16 and 6/17 machines exhibit their respective merits, and the IU-PM machine shows the best torque production ability in these CP-FSPM machines with the same design criteria

Test–retest reliability of laser evoked pain perception and fMRI BOLD responses

AbstractPain perception is a subjective experience and highly variable across time. Brain responses evoked by nociceptive stimuli are highly associated with pain perception and also showed considerable variability. To date, the test–retest reliability of laser-evoked pain perception and its associated brain responses across sessions remain unclear. Here, an experiment with a within-subject repeated-measures design was performed in 22 healthy volunteers. Radiant-heat laser stimuli were delivered on subjects’ left-hand dorsum in two sessions separated by 1–5 days. We observed that laser-evoked pain perception was significantly declined across sessions, coupled with decreased brain responses in the bilateral primary somatosensory cortex (S1), right primary motor cortex, supplementary motor area, and middle cingulate cortex. Intraclass correlation coefficients between the two sessions showed “fair” to “moderate” test–retest reliability for pain perception and brain responses. Additionally, we observed lower resting-state brain activity in the right S1 and lower resting-state functional connectivity between right S1 and dorsolateral prefrontal cortex in the second session than the first session. Altogether, being possibly influenced by changes of baseline mental state, laser-evoked pain perception and brain responses showed considerable across-session variability. This phenomenon should be considered when designing experiments for laboratory studies and evaluating pain abnormalities in clinical practice.</jats:p