Experimental Test of Bell inequalities with Six-Qubit Graph States

We report on the experimental realization of two different Bell inequality tests based on six-qubit linear-type and Y-shape graph states. For each of these states, the Bell inequalities tested are optimal in the sense that they provide the maximum violation among all Bell inequalities with stabilizing observables and possess the maximum resistance to noise.Comment: 4 pages, 2 figure

An Up-regulation of IRF-1 After a Spinal Cord Injury: Implications for Neuronal Apoptosis

Abstract IRF-1, a kind of transcription factor, is expressed in many cell types, except in early embryonal cells. IRF-1 has played an essential role in various physiological and pathological processes, including tumor immune surveillance, viral infection, development of immunity system and pro-inflammatory injury. However, the expression and function of IRF-1 in spinal cord injury (SCI) are still unknown. In this study, we have performed an acute SCI model in adult rats and investigated the dynamic changes of IRF-1 expression in the spinal cord. Western blot have shown that IRF-1 protein levels gradually increased, reaching a peak at day 3 and then gradually declined to a normal level at day 14 after SCI. Double immunofluorescence staining showed that IRF-1 immunoreactivity was found in neurons, but not in astrocytes and microglia. Additionally, colocalization of IRF-1/active caspase-3 was detected in neurons. In vitro, IRF-1 depletion, by short interfering RNA, obviously decreases neuronal apoptosis. In conclusion, this is the first description of IRF-1 expression in spinal cord injury. Our results suggested that IRF-1 might play crucial roles in CNS pathophysiology after SCI.</jats:p

Response of gadolinium doped liquid scintillator to charged particles: measurement based on intrinsic U/Th contamination

A measurement is reported for the response to charged particles of a liquid scintillator named EJ-335 doped with 0.5% gadolinium by weight. This liquid scintillator was used as the detection medium in a neutron detector. The measurement is based on the in-situ $\alpha$-particles from the intrinsic Uranium and Thorium contamination in the scintillator. The $\beta$-$\alpha$ and the $\alpha$-$\alpha$ cascade decays from the U/Th decay chains were used to select $\alpha$-particles. The contamination levels of U/Th were consequently measured to be $(5.54\pm0.15)\times 10^{-11}$ g/g, $(1.45\pm0.01)\times 10^{-10}$ g/g and $(1.07\pm0.01)\times 10^{-11}$ g/g for $^{232}$Th, $^{238}$U and $^{235}$U, respectively, assuming secular equilibrium. The stopping power of $\alpha$-particles in the liquid scintillator was simulated by the TRIM software. Then the Birks constant, $kB$, of the scintillator for $\alpha$-particles was determined to be $(7.28\pm0.23)$ mg/(cm$^{2}\cdot$MeV) by Birks' formulation. The response for protons is also presented assuming the $kB$ constant is the same as for $\alpha$-particles.Comment: 12 pages, 10 figures, 3 tables, prepared for submission to JINS

(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.

Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such, selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently, we have identified an effective analogue of resveratrol, (Z)3,4,5,4′-trans-tetramethoxystilbene (TMS) which selectively elevated the intracellular calcium level in gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. TMS exhibited significant inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR were inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum (ER) stress and AMPK activation. Proteomics analysis also further confirmed that mTOR pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together, TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients