The evolution of vortex tilt and vertical motion of tropical cyclones in directional shear flows

Recent studies have demonstrated the importance of moist dynamics on the intensification variability of tropical cyclones (TCs) in directional shear flows. Here, we propose that dry dynamics can account for many aspects of the structure change of TCs in moist simulations. The change of vortex tilt with height and time essentially determines the kinematic and thermodynamic structure of TCs experiencing directional shear flows, depending on how the environmental flow rotates with height; i.e., in a clockwise (CW) or counter-clockwise (CC) fashion. The vortex tilt precesses faster and is closer to the left-of-shear (with respect to the deep-layer shear), with smaller magnitude at equilibrium in CW hodographs than in CC hodographs. The low-level vortex tilt, and accordingly more low-level upward motions are ahead of the overall vortex tilt in CW hodographs, but are behind of the overall vortex tilt in CC hodographs. Such the configuration of vortex tilt in CW hodographs is potentially favorable for the continuous precession of convection into the up-shear region, but in CC hodographs is unfavorable. Most of the upward motions within a TC undergoing CW shear are concentrated in the down-shear-left region, whereas those in the CC shear are located in the down-shear-right region. Moreover, the upward (downward) motions are in-phase with positive (negative) local helicity in both CW and CC hodographs. Here we present an alternative mechanism that is associated with balanced dynamics in response to vortex tilt to explain the coincidence and also the distribution variability of vertical motions, as well as local helicity in directional shear flows. The balanced dynamics could explain the overlap of positive helicity and convection in both moist simulations and observations

Where is the future of China’s biogas? Review, forecast, and policy implications

This paper discusses the history and present status of different categories of biogas production in China, most of which are classified into rural household production, agriculture-based engineering production, and industry-based engineering production. To evaluate the future biogas production of China, five models including the Hubbert model, the Weibull model, the generalized Weng model, the H–C–Z model, and the Grey model are applied to analyze and forecast the biogas production of each province and the entire country. It is proved that those models which originated from oil research can also be applied to other energy sources. The simulation results reveal that China’s total biogas production is unlikely to keep on a fast-growing trend in the next few years, mainly due to a recent decrease in rural household production, and this greatly differs from the previous goal set by the official department. In addition, China’s biogas production will present a more uneven pattern among regions in the future. This paper will give preliminary explanation for the regional difference of the three biogas sectors and propose some recommendations for instituting corresponding policies and strategies to promote the development of the biogas industry in China

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here we compare the genome-scale proteomic and transcriptomic changes in human primary haematopoietic stem/progenitor cells and erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Mitochondrial factors including TFAM and PHB2 are selectively regulated through protein translation during erythroid specification. Depletion of TFAM in erythroid cells alters intracellular metabolism, leading to elevated histone acetylation, deregulated gene expression, and defective mitochondria and erythropoiesis. Mechanistically, mTORC1 signalling is enhanced to promote translation of mitochondria-associated transcripts through TOP-like motifs. Genetic and pharmacological perturbation of mitochondria or mTORC1 specifically impairs erythropoiesis in vitro and in vivo. Our studies support a mechanism for post-transcriptional control of erythroid mitochondria and may have direct relevance to haematologic defects associated with mitochondrial diseases and ageing

Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice

Hypertension is one of the most important, preventable causes of premature morbidity and mortality in the developed world. Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of blood pressure and is implicated in the pathogenesis of hypertension and heart failure. Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole enzyme responsible for the production of aldosterone in humans. To determine the effects of increased expression of human aldosterone synthase (hAS) on blood pressure (BP), we established transgenic mice carrying the hAS gene (cyp11B2). We showed that hAS overexpression increased levels of aldosterone in hAS+/− mice. On high salt diet (HS), BPs of hAS+/− mice were significantly increased compared with WT mice. Fadrozole (an inhibitor of aldosterone synthase) treatment significantly reduced BPs of hAS+/− mice on HS. This is the first time overexpression of AS in a transgenic mouse line has shown an ability to induce HP. Specifically inhibiting AS activity in these mice is a promising therapy for reducing hypertension. This hAS transgenic mouse model is therefore an ideal animal model for hypertension therapy studies

The role of quality of care and attitude towards disability in the relationship between severity of disability and quality of life: findings from a cross-sectional survey among people with physical disability in China

Background: People with physical disability (PWPD) is the largest subgroup of people with disability (PWD) in China, but few studies have been conducted among this vulnerable population. The objective of this study was to investigate the level of quality of life (QoL), self-perceived quality of care and support (QOCS), severity of disability and personal attitude towards disability among people with physical disability in China, as well as to identify how QoL can be affected by severity of disability through QOCS and personal attitude towards disability among PWPD. Methods: A cross-sectional study was conducted among 1,853 PWPD in Guangzhou, China. Data were collected on participants’ QoL, QOCS, personal attitude towards disability and severity of disability. Structural equation modeling was used to examine the effects of the other variables on QoL. Results: Even with a mild disability (mean score:1.72), relatively low levels of QoL (mean score: 2.65- 3.22) and QOCS (mean score: 2.95 to 3.28), as well as unfavorable personal attitude towards disability (mean score: 2.75 to 3.36) were identified among PWPD. According to SEM, we found that the influence of severity of physical disability on QoL is not only exerted directly, but is also indirectly through QOCS and their personal attitudes towards disability, with QOCS playing a more important mediating role than PWPD’s attitudes towards their own disability. Conclusions: Unfavorable health status was identified among PWPD in China. Focusing on improvement of assistance and care services has the potential to substantially improve PWPD’s QoL. Further research should focus on understanding the needs and their current state of health care of PWPD in China thus being able to develop better interventions for them