MARACAS: a real-time multicore VCPU scheduling framework

This paper describes a multicore scheduling and load-balancing framework called MARACAS, to address shared cache and memory bus contention. It builds upon prior work centered around the concept of virtual CPU (VCPU) scheduling. Threads are associated with VCPUs that have periodically replenished time budgets. VCPUs are guaranteed to receive their periodic budgets even if they are migrated between cores. A load balancing algorithm ensures VCPUs are mapped to cores to fairly distribute surplus CPU cycles, after ensuring VCPU timing guarantees. MARACAS uses surplus cycles to throttle the execution of threads running on specific cores when memory contention exceeds a certain threshold. This enables threads on other cores to make better progress without interference from co-runners. Our scheduling framework features a novel memory-aware scheduling approach that uses performance counters to derive an average memory request latency. We show that latency-based memory throttling is more effective than rate-based memory access control in reducing bus contention. MARACAS also supports cache-aware scheduling and migration using page recoloring to improve performance isolation amongst VCPUs. Experiments show how MARACAS reduces multicore resource contention, leading to improved task progress.http://www.cs.bu.edu/fac/richwest/papers/rtss_2016.pdfAccepted manuscrip

A novel backfill material for roof supports in the cut-through entries of longwall mining

SažetakTo enhance underground mining safety, researchers developed high-water and fast-setting cement (HWFSC). HWFSC essentially consists of two components and can be mixed with large quantities of water. To determine its mechanical strength, a series of uniaxial compressive strength tests were conducted on HWFSC specimens with different water-to-solid ratios. Results indicate that peak strength declined significantly with the increase in W/S ratio, whereas residual strength increased gradually with this enhancement. The feasibility of backfilling cut-through entries with HWFSC is then evaluated through a case study. The LaModel program was used to assess the yielding of the fender pillar and the deformation of the cut-through entry. Results also show that the use of HWFSC to backfill the cut-through entry addressed complicated ground control problems effectively. Further analysis also suggested that HWFSC was the optimal backfill material in terms of both economic cost and roof support safety

Gold nanocages covered by smart polymers for controlled release with near-infrared light

Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound for each effector. The ultraviolet light may cause damage to biological samples and is suitable only for in vitro studies because of its quick attenuation in tissue. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls. They can have strong absorption (for the photothermal effect) in the near-infrared while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a near-infrared laser. This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region

An academic achievements visualization research since the 21st century: research on salvage surgery for head and neck cancer

BackgroundHead and neck cancer is the 6th most common malignancy worldwide, and its incidence is still on the rise. The salvage surgery has been considered as an important treatment strategy for persistent or recurrent head and neck cancer. Therefore, we conducted a bibliometric analysis of salvage surgery for head and neck cancer since the 21st century.MethodsThe literature about salvage surgery of head and neck cancer in Web of Science was searched. CiteSpace and VOSviewer were used to analyze main countries, institutions, authors, journals, subject hotspots, trends, frontiers, etc.ResultsA total of 987 papers have been published since the 21st century. These publications were written by 705 authors from 425 institutions in 54 countries. The United States published 311 papers in this field and ranked first. Head & Neck was the most widely published journal. The main keyword clustering included terms such as #0 stereotactic radiotherapy (2012); #1 randomized multicenter (2007); #2 salvage surgery (2004); #3 functional outcomes (2014); #4 transoral robotic surgery (2013); #5 neck high-resolution computed tomography (2010); #6 complications (2008); #7 image guidance (2019). The current research frontiers that have been sustained are “recurrent”, “risk factors”, and “reirradiation”.ConclusionThe current situation of the salvage surgery for head and neck cancer in clinical treatments and basic scientific research were summarized, providing new perspectives for the development of salvage surgery for head and neck cancer in the future

Longitudinal Association between Selenium Levels and Hypertension in a Rural Elderly Chinese Cohort

Objectives Results from previous studies have been inconsistent on the association between selenium and hypertension, and very few studies on this subject have focused on the elderly population. The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort. Design A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders. The associations between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined. Setting Community-based setting in four rural areas in China. Subjects A total of 2000 elderly aged 65 years and over (mean 71.9±5.6 years) participated in this study. Measurements Nail selenium levels were measured in all subjects at baseline. Blood pressure measures and self-reported hypertension history were collected at baseline, 2.5 years and 7 years later. Hypertension was defined as systolic blood pressure 140 mmHg or higher, diastolic blood pressure 90 mmHg or higher, or reported use of anti-hypertensive medication. Results The rate of baseline hypertension was 63.50% in this cohort and the mean nail selenium level is 0.413±0.183µg/g. Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension. For the 635 participants with normal blood pressure at baseline, 360 had developed hypertension during follow-up. The incidence rate for hypertension was 45.83%, 52.27%, 62.50%, 70.48%, and 62.79% from the first selenium quintile to the fifth quintile respectively. Comparing to the lowest quintile group, the hazard ratios were 1.41 (95%CI: 1.03 to1.94), 1.93 (95%CI: 1.40 to 2.67), 2.35 (95%CI: 1.69 to 3.26) and 1.94 (95%CI: 1.36 to 22.77) for the second selenium quintile to the fifth quintile respectively. Conclusions Our findings suggest that high selenium may play a harmful role in the development of hypertension. Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism

An Integrated Contraflow Strategy for Multimodal Evacuation

To improve the efficiency of multimodal evacuation, a network aggregation method and an integrated contraflow strategy are proposed in this paper. The network aggregation method indicates the uncertain evacuation demand on the arterial subnetwork and balances accuracy and efficiency by refining the local road subnetworks. The integrated contraflow strategy contains three arterial configurations: noncontraflow to shorten the strategy setup time, full-lane contraflow to maximize the evacuation network capacity, and bus contraflow to realize the transit cycle operation. The application of this strategy takes two steps to provide transit priority during evacuation: solve the transit-based evacuation problem with a minimum-cost flow model, firstly, and then address the auto-based evacuation problem with a bilevel network flow model. The numerical results from optimizing an evacuation network for a super typhoon justify the validness and usefulness of the network aggregation method and the integrated contraflow strategy

Diffusion Model-Based Video Editing: A Survey

The rapid development of diffusion models (DMs) has significantly advanced image and video applications, making "what you want is what you see" a reality. Among these, video editing has gained substantial attention and seen a swift rise in research activity, necessitating a comprehensive and systematic review of the existing literature. This paper reviews diffusion model-based video editing techniques, including theoretical foundations and practical applications. We begin by overviewing the mathematical formulation and image domain's key methods. Subsequently, we categorize video editing approaches by the inherent connections of their core technologies, depicting evolutionary trajectory. This paper also dives into novel applications, including point-based editing and pose-guided human video editing. Additionally, we present a comprehensive comparison using our newly introduced V2VBench. Building on the progress achieved to date, the paper concludes with ongoing challenges and potential directions for future research.Comment: 23 pages, 12 figures, a project related to this paper can be found at https://github.com/wenhao728/awesome-diffusion-v2

Quantifying indoor navigation map information considering the dynamic map elements for scale adaptation

The indoor map is an indispensable component to visualize human users’ real-time locations and guided routes to find their destinations in large and complex buildings efficiently. The map design in existing mobile indoor navigation systems mostly considers either the user locations or the route segments but seldom considers the adaptation of the base map scale. Due to uneven densities of spatial elements, the complexity of routes, and the diversity of spatial distribution of navigation decision points, the base map information of indoor navigation maps varies greatly. Hence, it is inevitable to cause an inappropriate amount of map information at different locations and routes. Additionally, existing multi-scale representations of indoor maps are limited to certain scales but not adapted to building locations. Users have to adjust the map scales frequently through multiple interactions with the navigation system. In this study, we propose a method that considers the dynamic elements of indoor maps to quantify the map information for scale adaptation. The indoor navigation map information calculation includes both geometry information and spatial distribution information of static base map elements (area elements, POIs) and dynamic route elements (segments, decision points). The total map information is quantified by setting the weights of the two types of elements. An empirical study on indoor navigation map selection was conducted. Results show that the quantified map information using the proposed method can reflect a user-desired map better than the traditionally used scales

Evolution and impact of molecular glue research: a bibliometric analysis from 2000 to 2023

BackgroundMolecular glues, which reshape E3 ligase receptors to promote targeted protein degradation, are emerging as a promising therapeutic strategy, particularly in oncology, driven by rapidly advancing insights into their mechanisms and structural properties.ObjectiveThis study aims to offer an insightful depiction and visualization of the knowledge structure, prevalent themes, and emerging trends within the domain since the year 2000, employing bibliometric analysis to achieve this goal.MethodsTo conduct this research, a comprehensive collection of literature on molecular glues was sourced from the Web of Science database. Subsequently, the data underwent analysis utilizing CiteSpace and VOSviewer tools, enabling the identification of pivotal countries, institutions, authors, and journals, as well as the delineation of subject hotspots, trends, and the forefront of research in this evolving field.ResultSince 2000, 388 papers on molecular glues have been published, with a notable increase to an annual average of 43 articles post-2018. This research, contributed by 506 authors across 329 institutions, highlights the United States and China as leading nations in output, with 122 and 104 articles respectively. Takuzo Aida, Luc Brunsveld, and Christian Ottmann are identified as key authors. Nature emerges as the foremost publication venue, while the Chinese Academy of Sciences is the top contributing institution, underscoring the global engagement and interdisciplinary nature of molecular glue research. This study identified 19 distinct research clusters within the molecular glues domain.ConclusionWe reveal the current status, hotspots, and trends of molecular glue research since 2000, offering insights and novel scholarly perspectives on the field’s prevailing limitations