A Mine Main Fans Switchover System with Lower Air Flow Volatility based on Improved Particle Swarm Optimization Algorithm

A reliable ventilation system is essential for maintaining a comfortable working environment and ensuring safety production in an underground coal mine. The automated fan switchover technique was developed for changing the main fan for maintenance with lower air flow volatility of underground mine in the switchover process. This article established the optimization model in the main fans switchover process, used the improved particle swarm optimization algorithm to solve the model, and achieved minimum air flow volatility in the fans switchover process. Compared to previous studies, computer simulations have shown that the proposed algorithm can effectively find the global optimal solution with less initial parameters and achieved lower air flow volatility in underground mine. The particle swarm optimization solution, searching diversity, prevents it from confining to local optimal solutions and enhances convergence. The reasonable step length is beneficial to reduce the air flow volatility and main fans switchover time. The air flow volatility is larger comparatively when some doors are nearly open or closed fully at the start—stop phase of the switchover process. A case application in a China\u27s domestic coal mine shows that the air flow volatility of the underground mine in the main fans switchover process is no more than 0.4%

Recent advances in understanding the immune microenvironment in ovarian cancer

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress in medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. The tumor microenvironment (TME) includes cancer cells, fibroblasts linked to cancer (CAFs), immune-inflammatory cells, and the substances these cells secrete, along with non-cellular components in the extracellular matrix (ECM). First, the TME mainly plays a role in inhibiting tumor growth and protecting normal cell survival. As tumors progress, the TME gradually becomes a place to promote tumor cell progression. Immune cells in the TME have attracted much attention as targets for immunotherapy. Immune checkpoint inhibitor (ICI) therapy has the potential to regulate the TME, suppressing factors that facilitate tumor advancement, reactivating immune cells, managing tumor growth, and extending the survival of patients with advanced cancer. This review presents an outline of current studies on the distinct cellular elements within the OC TME, detailing their main functions and possible signaling pathways. Additionally, we examine immunotherapy rechallenge in OC, with a specific emphasis on the biological reasons behind resistance to ICIs

Interdecadal variation of precipitation over Yunnan, China in summer and its possible causes

In recent decades, severe drought conditions have become increasingly frequent in Yunnan, Southwest China. The extreme drought events cause huge losses to agricultural economy, ecological security and human health. To uncover the reasons behind the worsening drought conditions, this study investigates the interdecadal variability (IDV) of summer precipitation in Yunnan during 1961–2019 and its association with the Indo-Pacific Sea surface temperature (SST) configuration based on gauge observation and reanalysis data. The dominant mode of summer precipitation IDV in Yunnan shows a uniform pattern characterizing the alternations of flood and drought. Specifically, a relatively wet period persists from the early 1990s to the early 2000s, followed by a relatively dry period from the early 2000s to the late 2010s. The IDV of precipitation is consistent with the IDV of the column-integrated water vapor flux divergence, where the wind anomalies play a major role in modulating the moisture supply. The main SST forcings of the IDV of precipitation include the sea surface temperature anomalies (SSTAs) over the Bay of Bengal (BOB), the Western Pacific Warm Pool (WPWP), and the western North Pacific (WNP). The negative SSTAs over the BOB and the WPWP trigger a Gill-Matsuno-type response that enhances the cyclonic curvature over Yunnan. The SSTAs over the WNP show a tripole pattern that weakens the WNP subtropical high and further enhances the cyclonic anomaly over Yunnan. The above SST configuration also favors moisture transport to Yunnan. Numerical experiments verify the key physical processes

TinyVisor: An extensible secure framework on Android platforms

National Research Foundation (NRF) Singapor

Effect of Ultrasonic Pretreatment on the Gel Properties and Structure of Flaxseed Gum-Soybean Protein Isolate Composite Gels

Objective: This study aimed to investigate the impact of different ultrasonic power and time pretreatments on the structures and gel properties of the flaxseed gum and soybean protein isolate composite gel induced by TG enzyme. Methods: The structural characteristics, molecular conformation, and micro-network structures of the composite gel under varying ultrasonic conditions were analyzed using a texture analyzer, laser particle size meter, circular dichroism (CD), fluorescence spectrum, and scanning electron microscope (SEM). Results: The 50% power ultrasound pretreatment for 10 min could significantly improve the hardness, adhesiveness, chewiness, cohesiveness and water-holding property of the composite gel, and reduce its adhesiveness. After 50% power ultrasound pretreatment for 10 min, the α-helix and β-turn content of composite gel proteins decreased, and the content of β-folding and irregular curls increased, and the fluorescence intensity increased, which was conducive to the improvement of the functional properties of the gel. The microstructure of the composite gel became ordered from disorder, the network density increased, the pore diameter became smaller, and the pore wall was thickened. While after increasing the ultrasound power to 80%, the gel properties fluctuated only slightly and the microstructure was destroyed. Conclusion: 50% power ultrasound pretreatment for 10 min can significantly improve the gel properties and network structure of TG enzyme cross-linked flaxseed gum-soybean protein isolate composite

Gut Symbionts alleviate Mash Through a Secondary Bile acid Biosynthetic Pathway

The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been established. Here, by developing a click-chemistry-based enrichment strategy, we identified several microbial-derived bile acids, including the previously uncharacterized 3-succinylated cholic acid (3-sucCA), which is negatively correlated with liver damage in patients with liver-tissue-biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD). By screening human bacterial isolates, we identified Bacteroides uniformis strains as effective producers of 3-sucCA both in vitro and in vivo. By activity-based protein purification and identification, we identified an enzyme annotated as β-lactamase in B. uniformis responsible for 3-sucCA biosynthesis. Furthermore, we found that 3-sucCA is a lumen-restricted metabolite and alleviates MASH by promoting the growth of Akkermansia muciniphila. together, our data offer new insights into the gut microbiota-liver axis that may be leveraged to augment the management of MASH