NeuralMPS: Non-Lambertian Multispectral Photometric Stereo via Spectral Reflectance Decomposition

Multispectral photometric stereo(MPS) aims at recovering the surface normal of a scene from a single-shot multispectral image captured under multispectral illuminations. Existing MPS methods adopt the Lambertian reflectance model to make the problem tractable, but it greatly limits their application to real-world surfaces. In this paper, we propose a deep neural network named NeuralMPS to solve the MPS problem under general non-Lambertian spectral reflectances. Specifically, we present a spectral reflectance decomposition(SRD) model to disentangle the spectral reflectance into geometric components and spectral components. With this decomposition, we show that the MPS problem for surfaces with a uniform material is equivalent to the conventional photometric stereo(CPS) with unknown light intensities. In this way, NeuralMPS reduces the difficulty of the non-Lambertian MPS problem by leveraging the well-studied non-Lambertian CPS methods. Experiments on both synthetic and real-world scenes demonstrate the effectiveness of our method

A case report of HER2-positive descending colon cancer with peritoneal metastasis and literature review

Human epidermal growth factor receptor 2 (HER2) is an anti-cancer drug target for colon cancer. Among patients with colorectal malignancy (colorectal cancer, CRC), those with HER2 mutations have a poor overall prognosis and a significantly increased drug resistance. In recent years, anti-HER2 therapeutic drugs have developed rapidly. According to several clinical studies and case reports, anti-HER2 therapy, as an emerging anti-cancer approach, plays a crucial role in the treatment of HER2-positive CRC patients. Here, we present a case of HER2-positive descending colon cancer with peritoneal metastasis. The patient is a 26-year-old male, diagnosed with malignant tumor of the descending colon with peritoneal metastasis in April 2020. After multiple treatment modalities, the disease progressed. After chemotherapy with Trastuzumab Deruxtecan (T-DXd/DS-8201), the metastatic foci significantly shrank, and after surgical resection, a tumor-free state (NED) was achieved. Up to now, the patient’s survival period has reached 56 months

Boosting with an aerosolized Ad5-nCoV elicited robust immune responses in inactivated COVID-19 vaccines recipients

IntroductionThe SARS-CoV-2 Omicron variant has become the dominant SARS-CoV-2 variant and exhibits immune escape to current COVID-19 vaccines, the further boosting strategies are required.MethodsWe have conducted a non-randomized, open-label and parallel-controlled phase 4 trial to evaluate the magnitude and longevity of immune responses to booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, a recombinant protein subunit vaccine (ZF2001) or homologous inactivated vaccine (CoronaVac) in those who received two doses of inactivated COVID-19 vaccines. ResultsThe aerosolized Ad5-nCoV induced the most robust and long-lasting neutralizing activity against Omicron variant and IFNg T-cell response among all the boosters, with a distinct mucosal immune response. SARS-CoV-2-specific mucosal IgA response was substantially generated in subjects boosted with the aerosolized Ad5-nCoV at day 14 post-vaccination. At month 6, participants boosted with the aerosolized Ad5-nCoV had remarkably higher median titer and seroconversion of the Omicron BA.4/5-specific neutralizing antibody than those who received other boosters. DiscussionOur findings suggest that aerosolized Ad5-nCoV may provide an efficient alternative in response to the spread of the Omicron BA.4/5 variant.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=152729, identifier ChiCTR2200057278

Experimental Study on Improvement Mechanism of Electric Heating-Assisted Cyclic Steam Stimulation of Horizontal Well

To resolve the issues of the high porous medium flow resistance, low oil production rate, high oil decline rate, and low oil recovery factor for the cyclic steam stimulation (CSS) of horizontal wells in heavy oil reservoirs, the CSS method assisted by the electric heating (E-CSS) of horizontal wells was proposed in this study. Combining the heat from electric heating and steam during E-CSS, the analytical model of formation temperature rise was established for the three phases of electric-assisted CSS (i.e., injection, soaking, production), and physical experiments were carried out to compare the performance of conventional CSS and E-CSS. The experimental results were used to validate the analytical model and reveal the impact of the key electric heating mechanism on the horizontal CSS performance. Meanwhile, the typical well model was used to forecast the E-CSS potential. The results indicate that electric heating can achieve uniform heating in the steam injection phase, maintain heating around the wellbore in the soak phase, and reduce flow resistance and enhance oil output in the production phase. Forecasts of the typical well model indicate that electric heating can enhance the oil recovery factor by 9.4% and the oil-steam ratio from 0.14 to 0.23, implying a significant application potential in heavy oil reservoirs developed by horizontal CSS