Global method for a class of operation optimization problem in steel rolling systems

Many steel products are produced in hot or cold rolling lines with multiple stands. The steel material becomes thinner after being rolled at each stand. Steady-state parameters for controlling the rolling line need to be set so as to satisfy the final product specifications and minimize the total energy consumption. This paper develops a generalized geometric programming model for this setting problem and proposes a global method for solving it. The model can be expressed with a linear objective function and a set of constraints including nonconvex ones. Through constructing lower bounds of some components, the constraints can be converted to convex ones approximately. A sequential approximation method is proposed in a gradually reduced interval to improve accuracy and efficiency. However, the resulting convex programming model in each iteration is still complicated. To reduce the power, it is transformed into a second-order cone programming (SOCP) model and solved using alternating direction method of multipliers (ADMM). The effectiveness of the global method is tested using real data from a hot-rolling line with seven stands. The results demonstrate that the proposed global method solves the problem effectively and reduces the energy consumption

Signature of coexistence of superconductivity and ferromagnetism in two-dimensional NbSe\u3csub\u3e2\u3c/sub\u3e triggered by surface molecular adsorption

Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we report the use of surface molecular adsorption to induce ferromagnetism in two-dimensional superconducting NbSe2, representing the freestanding case of the coexistence of superconductivity and ferromagnetism in one two-dimensional nanomaterial. Surface-structural modulation of the ultrathin superconducting NbSe2 by polar reductive hydrazine molecules triggers a slight elongation of the covalent Nb–Se bond, which weakens the covalent interaction and enhances the ionicity of the tetravalent Nb with unpaired electrons, yielding ferromagnetic ordering. The induced ferromagnetic momentum couples with conduction electrons generating unique correlated effects of intrinsic negative magnetoresistance and the Kondo effect. We anticipate that the surface molecular adsorption will be a powerful tool to regulate spin ordering in the two-dimensional paradigm

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Signature of coexistence of superconductivity and ferromagnetism in two-dimensional NbSe\u3csub\u3e2\u3c/sub\u3e triggered by surface molecular adsorption

Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we report the use of surface molecular adsorption to induce ferromagnetism in two-dimensional superconducting NbSe2, representing the freestanding case of the coexistence of superconductivity and ferromagnetism in one two-dimensional nanomaterial. Surface-structural modulation of the ultrathin superconducting NbSe2 by polar reductive hydrazine molecules triggers a slight elongation of the covalent Nb–Se bond, which weakens the covalent interaction and enhances the ionicity of the tetravalent Nb with unpaired electrons, yielding ferromagnetic ordering. The induced ferromagnetic momentum couples with conduction electrons generating unique correlated effects of intrinsic negative magnetoresistance and the Kondo effect. We anticipate that the surface molecular adsorption will be a powerful tool to regulate spin ordering in the two-dimensional paradigm

Advancements in Phase-Field Modeling for Fracture in Nonlinear Elastic Solids under Finite Deformations

The prediction of failure mechanisms in nonlinear elastic materials holds significant importance in engineering applications. In recent years, the phase-field model has emerged as an effective approach for addressing fracture problems. Compared with other discontinuous fracture methods, the phase-field method allows for the easy simulation of complex fracture paths, including crack initiation, propagation, coalescence, and branching phenomena, through a scalar field known as the phase field. This method offers distinct advantages in tackling complex fracture problems in nonlinear elastic materials and exhibits substantial potential in material design and manufacturing. The current research has indicated that the energy distribution method employed in phase-field approaches significantly influences the simulated results of material fracture, such as crack initiation load, crack propagation path, crack branching, and so forth. This impact is particularly pronounced when simulating the fracture of nonlinear materials under finite deformation. Therefore, this review outlines various strain energy decomposition methods proposed by researchers for phase-field models of fracture in tension–compression symmetric nonlinear elastic materials. Additionally, the energy decomposition model for tension–compression asymmetric nonlinear elastic materials is also presented. Moreover, the fracture behavior of hydrogels is investigated through the application of the phase-field model with energy decomposition. In addition to summarizing the research on these types of nonlinear elastic body fractures, this review presents numerical benchmark examples from relevant studies to assess and validate the accuracy and effectiveness of the methods presented

Global method for a class of operation optimization problem in steel rolling systems

Many steel products are produced in hot or cold rolling lines with multiple stands. The steel material becomes thinner after being rolled at each stand. Steady-state parameters for controlling the rolling line need to be set so as to satisfy the final product specifications and minimize the total energy consumption. This paper develops a generalized geometric programming model for this setting problem and proposes a global method for solving it. The model can be expressed with a linear objective function and a set of constraints including nonconvex ones. Through constructing lower bounds of some components, the constraints can be converted to convex ones approximately. A sequential approximation method is proposed in a gradually reduced interval to improve accuracy and efficiency. However, the resulting convex programming model in each iteration is still complicated. To reduce the power, it is transformed into a second-order cone programming (SOCP) model and solved using alternating direction method of multipliers (ADMM). The effectiveness of the global method is tested using real data from a hot-rolling line with seven stands. The results demonstrate that the proposed global method solves the problem effectively and reduces the energy consumption

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma

Abstract Background Icaritin, an active ingredient of the Chinese herb Epimedium, plays an anti-tumor role in liver cancer by inhibiting the proliferation of hepatocellular cells and promoting their apoptosis. In China, phase II and a large phase III clinical trial of icaritin reagent for the treatment of hepatocellular cancer is under-going, but the specific mechanism of icaritin action was unclear. Alpha-fetoprotein (AFP), an oncofetal protein, produced in the healthy fetal liver and yolk sac. Intracellular AFP promoted cellular proliferation and inhibited cellular apoptosis in hepatocellular carcinoma (HCC). The study was aimed to investigate the effect of icaritin on HCC through p53/AFP pathway. Methods Real-time RT PCR and western blot were used to detect p53 and AFP expression levels in HCC cells treated with icaritin. The mechanism of icaritin affecting p53 expression was verified by ubiquitination experiment, and the binding activity of icaritin on p53 in AFP promoter region was verified by luciferase experiment. EdU, MTT and flow cytometry were used to determine whether icaritin affected HCC cellular proliferation and apoptosis through p53/ AFP pathway. Expression levels of p53 and AFP in xenograft mouse model were determined by western blotting. Results Our results showed icaritin inhibited AFP expression at mRNA and protein level. AFP was also identified as the target gene of the p53 transcription factor. Icaritin abrogated murine double minute (Mdm) 2-mediated p53 ubiquitination degradation to improve the stability of p53. Up-regulated p53 protein levels then transcriptionally inhibited the AFP promoter. Icaritin-mediated decrease of AFP through Mdm2/p53 pathways inhibited HCC cellular proliferation and promoted HCC cellular apoptosis. Conclusion Our findings revealed the mechanism of icaritin in promoting apoptosis and inhibiting proliferation in liver cancer cells. The regulatory mechanism of icaritin in AFP protein down-regulation provides a theoretical and experimental basis for further research into new drugs for the treatment of liver cancer. </jats:sec

GP73-mediated secretion of AFP and GP73 promotes proliferation and metastasis of hepatocellular carcinoma cells

AbstractGolgi protein 73 (GP73) and alpha fetoprotein (AFP) serve as biomarkers for the diagnosis of hepatocellular carcinoma (HCC), and their serum levels correlate with patients’ outcomes. However, the mechanisms underlying these correlations are unknown. Here we show that GP73 increased the secretion of AFP through direct binding to AFP, thereby promoting the proliferation and metastasis of HCC cells that expressed AFP and its receptor (AFPR). Extracellular GP73 contributed to the proliferation and metastasis of HCC cells independent of AFP and AFPR. Moreover, extracellular AFP and GP73 synergized to enhance the malignant phenotype of HCC cells. Furthermore, extracellular GP73 and AFP inhibited the antitumor effects of sorafenib and synergistically increased the drug resistance of HCC cells. These findings, which reveal the mechanism of GP73-mediated secretion of AFP and its effects on the malignant phenotype of HCC cells, provide a comprehensive theoretical basis for the diagnosis and treatment of HCC and identify potential drug targets.</jats:p