Collaborative systems for NASA science, engineering, and mission operations

We describe a set of ten collaborative systems projects developed at NASA Ames Research Center over the past ten years. Our goal is to design new information technologies and collaboration tools that facilitate the process by which NASA engineers, scientists, and mission personnel collaborate in their unique work settings. We employ information management, artificial intelligence, and participatory design practices to build systems that are highly usable, augment human cognition, and support distributed NASA teams. NASA settings and applications serve as valuable testbeds for studying collaboration and developing new collaborative technologies

Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs

Chemical equations presented. JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation- transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure. © 2011 American Chemical Society